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Studies of the toxicological potential of capsinoids XIV: a 26-week gavage toxicity study of dihydrocapsiate in rats.
Int J Toxicol. 2010 Mar; 29(2 Suppl):27S-54S.IJ

Abstract

To further evaluate the safety of dihydrocapsiate (4-hydroxy-3-methoxybenzyl 8-methylnonanoate, CAS No. 205687-03-2), a 26-week gavage toxicity study was conducted in Sprague-Dawley rats (20/sex/group). Test animals received either dihydrocapsiate, 100, 300, or 1000 mg/kg/day, or vehicle (medium-chain triglyceride) by gavage and were observed for antemortem and postmortem signs of toxicity including changes in clinical signs, body weights, food consumption, water intake, ophthalmology, clinical pathology (clinical chemistry, hematology, urinalysis), tissue findings (macroscopic and microscopic examination), as well as organ weights. After the end of the dosing period, reversibility was assessed (10/sex/group for the control and 1000 mg/kg groups) following a 4-week recovery period. There were no adverse or toxicological changes observed in clinical signs, body weight, food consumption, water intake, ophthalmology, urinalysis, hematology, blood chemistry, organ weights, or histopathology. It was concluded that the no observable adverse effect level (NOAEL) of dihydrocapsiate was 1000 mg/kg/day for both sexes in this 26-week gavage study.

Authors+Show Affiliations

Toxicology and Pathology, Nonclinical Developmental Research Dept, Pharmaceutical Research Laboratories, Ajinomoto Co, Inc, 1-1, Suzuki-cho, Kawasaki-shi, Kanagawa-ken 210-8681, Japan. terutaka_kodama@ajinomoto.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20388822

Citation

Kodama, Terutaka, et al. "Studies of the Toxicological Potential of Capsinoids XIV: a 26-week Gavage Toxicity Study of Dihydrocapsiate in Rats." International Journal of Toxicology, vol. 29, no. 2 Suppl, 2010, 27S-54S.
Kodama T, Masuyama T, Kayahara T, et al. Studies of the toxicological potential of capsinoids XIV: a 26-week gavage toxicity study of dihydrocapsiate in rats. Int J Toxicol. 2010;29(2 Suppl):27S-54S.
Kodama, T., Masuyama, T., Kayahara, T., Tsubuku, S., Ohishi, T., Wagner, B. M., & Bernard, B. K. (2010). Studies of the toxicological potential of capsinoids XIV: a 26-week gavage toxicity study of dihydrocapsiate in rats. International Journal of Toxicology, 29(2 Suppl), 27S-54S. https://doi.org/10.1177/1091581809358925
Kodama T, et al. Studies of the Toxicological Potential of Capsinoids XIV: a 26-week Gavage Toxicity Study of Dihydrocapsiate in Rats. Int J Toxicol. 2010;29(2 Suppl):27S-54S. PubMed PMID: 20388822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies of the toxicological potential of capsinoids XIV: a 26-week gavage toxicity study of dihydrocapsiate in rats. AU - Kodama,Terutaka, AU - Masuyama,Takeshi, AU - Kayahara,Takashi, AU - Tsubuku,Shoji, AU - Ohishi,Takumi, AU - Wagner,Bernard M, AU - Bernard,Bruce K, PY - 2010/4/15/entrez PY - 2010/4/23/pubmed PY - 2010/7/31/medline SP - 27S EP - 54S JF - International journal of toxicology JO - Int J Toxicol VL - 29 IS - 2 Suppl N2 - To further evaluate the safety of dihydrocapsiate (4-hydroxy-3-methoxybenzyl 8-methylnonanoate, CAS No. 205687-03-2), a 26-week gavage toxicity study was conducted in Sprague-Dawley rats (20/sex/group). Test animals received either dihydrocapsiate, 100, 300, or 1000 mg/kg/day, or vehicle (medium-chain triglyceride) by gavage and were observed for antemortem and postmortem signs of toxicity including changes in clinical signs, body weights, food consumption, water intake, ophthalmology, clinical pathology (clinical chemistry, hematology, urinalysis), tissue findings (macroscopic and microscopic examination), as well as organ weights. After the end of the dosing period, reversibility was assessed (10/sex/group for the control and 1000 mg/kg groups) following a 4-week recovery period. There were no adverse or toxicological changes observed in clinical signs, body weight, food consumption, water intake, ophthalmology, urinalysis, hematology, blood chemistry, organ weights, or histopathology. It was concluded that the no observable adverse effect level (NOAEL) of dihydrocapsiate was 1000 mg/kg/day for both sexes in this 26-week gavage study. SN - 1092-874X UR - https://www.unboundmedicine.com/medline/citation/20388822/Studies_of_the_toxicological_potential_of_capsinoids_XIV:_a_26_week_gavage_toxicity_study_of_dihydrocapsiate_in_rats_ L2 - https://journals.sagepub.com/doi/10.1177/1091581809358925?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -