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Dithranol therapy in childhood psoriasis: unjustifiably on the verge of falling into oblivion.
Dermatology. 2010; 220(4):329-32.D

Abstract

BACKGROUND

In childhood psoriasis, physicians aim for an effective and safe treatment such as with dithranol. This study presents the largest study of dithranol-treated patients described in the literature.

OBJECTIVE

The aim of the study was to determine the position of dithranol in the treatment strategy for psoriasis.

METHODS

All juvenile patients receiving dithranol treatment at our center were evaluated retrospectively.

RESULTS

Sixty patients (with 82 treatment episodes in total) were included. The mean age at the start of dithranol treatment was 11.1 years (range: 3.7-17.9 years). The result of the treatment was: excellent (3.7%), good (69.5%), moderate (8.5%), reasonable (13.4%) or disappointing (4.9%). Mild irritation was seen in 39%, and severe irritation in 63% of the patients.

CONCLUSIONS

Dithranol can be regarded as an efficacious and safe topical therapy for the treatment of childhood psoriasis. It is a valuable alternative topical treatment which should not be disregarded in the treatment regimen for childhood psoriasis and should be commenced before ultraviolet or systemic treatments are initiated.

Authors+Show Affiliations

Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. M.deJager@derma.umcn.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20389024

Citation

de Jager, M E A., et al. "Dithranol Therapy in Childhood Psoriasis: Unjustifiably On the Verge of Falling Into Oblivion." Dermatology (Basel, Switzerland), vol. 220, no. 4, 2010, pp. 329-32.
de Jager ME, van de Kerkhof PC, de Jong EM, et al. Dithranol therapy in childhood psoriasis: unjustifiably on the verge of falling into oblivion. Dermatology (Basel). 2010;220(4):329-32.
de Jager, M. E., van de Kerkhof, P. C., de Jong, E. M., & Seyger, M. M. (2010). Dithranol therapy in childhood psoriasis: unjustifiably on the verge of falling into oblivion. Dermatology (Basel, Switzerland), 220(4), 329-32. https://doi.org/10.1159/000278241
de Jager ME, et al. Dithranol Therapy in Childhood Psoriasis: Unjustifiably On the Verge of Falling Into Oblivion. Dermatology (Basel). 2010;220(4):329-32. PubMed PMID: 20389024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dithranol therapy in childhood psoriasis: unjustifiably on the verge of falling into oblivion. AU - de Jager,M E A, AU - van de Kerkhof,P C M, AU - de Jong,E M G J, AU - Seyger,M M B, Y1 - 2010/04/09/ PY - 2009/12/17/received PY - 2010/01/19/accepted PY - 2010/4/15/entrez PY - 2010/4/15/pubmed PY - 2010/10/15/medline SP - 329 EP - 32 JF - Dermatology (Basel, Switzerland) JO - Dermatology (Basel) VL - 220 IS - 4 N2 - BACKGROUND: In childhood psoriasis, physicians aim for an effective and safe treatment such as with dithranol. This study presents the largest study of dithranol-treated patients described in the literature. OBJECTIVE: The aim of the study was to determine the position of dithranol in the treatment strategy for psoriasis. METHODS: All juvenile patients receiving dithranol treatment at our center were evaluated retrospectively. RESULTS: Sixty patients (with 82 treatment episodes in total) were included. The mean age at the start of dithranol treatment was 11.1 years (range: 3.7-17.9 years). The result of the treatment was: excellent (3.7%), good (69.5%), moderate (8.5%), reasonable (13.4%) or disappointing (4.9%). Mild irritation was seen in 39%, and severe irritation in 63% of the patients. CONCLUSIONS: Dithranol can be regarded as an efficacious and safe topical therapy for the treatment of childhood psoriasis. It is a valuable alternative topical treatment which should not be disregarded in the treatment regimen for childhood psoriasis and should be commenced before ultraviolet or systemic treatments are initiated. SN - 1421-9832 UR - https://www.unboundmedicine.com/medline/citation/20389024/Dithranol_therapy_in_childhood_psoriasis:_unjustifiably_on_the_verge_of_falling_into_oblivion_ L2 - https://www.karger.com?DOI=10.1159/000278241 DB - PRIME DP - Unbound Medicine ER -