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Do different substitution patterns or plant origin in hydroxyethyl starches affect blood coagulation in vitro?
Blood Coagul Fibrinolysis. 2010 Jul; 21(5):448-51.BC

Abstract

The effect of hydroxyethyl starches (HES) on blood coagulation is affected by their molecular weight, their molar substitution and the C2/C6 ratio. The solutions of 6% HES 130/0.4 and 6% HES 130/0.42 have similar molecular weight and molar substitution but different C2/C6 ratio and plant origin. In the present study, the comparative effect of 6% HES 130/0.4 versus 6% HES 130/0.42 on blood coagulation was investigated in vitro. Thirty milliliter of blood was obtained from 10 healthy volunteers and was diluted by 10, 30 and 50% using either 6% HES 130/0.4 or HES 130/0.42, respectively. Blood coagulation was assessed using thrombelastography measurements (clotting time, clot formation time, maximal clot firmness and alpha-angle). The assessment of platelet function was performed with whole blood aggregometry after adding thrombin-receptor-activating protein. No differences were noted between respective dilutions of the two HES. Both colloids produced significant reductions below the reference values range in clotting time at 10, 30 and 50% dilutions. The 50% dilution of both colloids resulted in significant reduction of maximal clot firmness, alpha-angle and platelet aggregation. The present study showed that the corn-derived 6% HES 130/0.4 and the potato-derived 6% HES 130/0.42 have the same effect on blood coagulation in vitro.

Authors+Show Affiliations

Department of Anesthesiology, University of Athens, 'Attikon' Hospital, Greece. k_kalimeris@hotmail.com <k_kalimeris@hotmail.com>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20389236

Citation

Matsota, Paraskevi, et al. "Do Different Substitution Patterns or Plant Origin in Hydroxyethyl Starches Affect Blood Coagulation in Vitro?" Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, vol. 21, no. 5, 2010, pp. 448-51.
Matsota P, Politou M, Kalimeris K, et al. Do different substitution patterns or plant origin in hydroxyethyl starches affect blood coagulation in vitro? Blood Coagul Fibrinolysis. 2010;21(5):448-51.
Matsota, P., Politou, M., Kalimeris, K., Apostolaki, S., Merkouri, E., Gialeraki, A., Travlou, A., & Kostopanagiotou, G. (2010). Do different substitution patterns or plant origin in hydroxyethyl starches affect blood coagulation in vitro? Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, 21(5), 448-51. https://doi.org/10.1097/MBC.0b013e328338db67
Matsota P, et al. Do Different Substitution Patterns or Plant Origin in Hydroxyethyl Starches Affect Blood Coagulation in Vitro. Blood Coagul Fibrinolysis. 2010;21(5):448-51. PubMed PMID: 20389236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Do different substitution patterns or plant origin in hydroxyethyl starches affect blood coagulation in vitro? AU - Matsota,Paraskevi, AU - Politou,Marianna, AU - Kalimeris,Konstantinos, AU - Apostolaki,Stella, AU - Merkouri,Efrosyni, AU - Gialeraki,Argyri, AU - Travlou,Anthi, AU - Kostopanagiotou,Georgia, PY - 2010/4/15/entrez PY - 2010/4/15/pubmed PY - 2011/2/4/medline SP - 448 EP - 51 JF - Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis JO - Blood Coagul Fibrinolysis VL - 21 IS - 5 N2 - The effect of hydroxyethyl starches (HES) on blood coagulation is affected by their molecular weight, their molar substitution and the C2/C6 ratio. The solutions of 6% HES 130/0.4 and 6% HES 130/0.42 have similar molecular weight and molar substitution but different C2/C6 ratio and plant origin. In the present study, the comparative effect of 6% HES 130/0.4 versus 6% HES 130/0.42 on blood coagulation was investigated in vitro. Thirty milliliter of blood was obtained from 10 healthy volunteers and was diluted by 10, 30 and 50% using either 6% HES 130/0.4 or HES 130/0.42, respectively. Blood coagulation was assessed using thrombelastography measurements (clotting time, clot formation time, maximal clot firmness and alpha-angle). The assessment of platelet function was performed with whole blood aggregometry after adding thrombin-receptor-activating protein. No differences were noted between respective dilutions of the two HES. Both colloids produced significant reductions below the reference values range in clotting time at 10, 30 and 50% dilutions. The 50% dilution of both colloids resulted in significant reduction of maximal clot firmness, alpha-angle and platelet aggregation. The present study showed that the corn-derived 6% HES 130/0.4 and the potato-derived 6% HES 130/0.42 have the same effect on blood coagulation in vitro. SN - 1473-5733 UR - https://www.unboundmedicine.com/medline/citation/20389236/Do_different_substitution_patterns_or_plant_origin_in_hydroxyethyl_starches_affect_blood_coagulation_in_vitro L2 - https://doi.org/10.1097/MBC.0b013e328338db67 DB - PRIME DP - Unbound Medicine ER -