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Constituents from the testas of Castanea mollissima Blume with alpha-glucosidase inhibitory activity.
J Asian Nat Prod Res. 2010 Feb; 12(2):144-9.JA

Abstract

In the screening of biologically active constituents from medicinal plants, the 75% EtOH extract of the testas of Castanea mollissima Blume showed potent alpha-glucosidase inhibitory activity. By means of various chromatographic methods, the extract gave a new dammarane-type triterpene 1 along with 17 known compounds. The structure of 1 was determined to be 3beta-acetoxy-20-oxo-21-nordammaran-23-oic acid by HRMS and NMR studies including 2D NMR experiments. The new compound and some known compounds showed potent alpha-glucosidase inhibitory activity with acarbose as a positive control.

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Authors+Show Affiliations

Gao HY
School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang, China.
Wu D
No affiliation info available
Lu C
No affiliation info available
Xu XM
No affiliation info available
Huang J
No affiliation info available
Sun BH
No affiliation info available
Wu LJ
No affiliation info available

MeSH

FagaceaeGlycoside Hydrolase InhibitorsMolecular StructureNuclear Magnetic Resonance, BiomolecularPlants, MedicinalTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20390758

Citation

Gao, Hui-Yuan, et al. "Constituents From the Testas of Castanea Mollissima Blume With Alpha-glucosidase Inhibitory Activity." Journal of Asian Natural Products Research, vol. 12, no. 2, 2010, pp. 144-9.
Gao HY, Wu D, Lu C, et al. Constituents from the testas of Castanea mollissima Blume with alpha-glucosidase inhibitory activity. J Asian Nat Prod Res. 2010;12(2):144-9.
Gao, H. Y., Wu, D., Lu, C., Xu, X. M., Huang, J., Sun, B. H., & Wu, L. J. (2010). Constituents from the testas of Castanea mollissima Blume with alpha-glucosidase inhibitory activity. Journal of Asian Natural Products Research, 12(2), 144-9. https://doi.org/10.1080/10286020903451757
Gao HY, et al. Constituents From the Testas of Castanea Mollissima Blume With Alpha-glucosidase Inhibitory Activity. J Asian Nat Prod Res. 2010;12(2):144-9. PubMed PMID: 20390758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Constituents from the testas of Castanea mollissima Blume with alpha-glucosidase inhibitory activity. AU - Gao,Hui-Yuan, AU - Wu,Di, AU - Lu,Chuan, AU - Xu,Xiao-Min, AU - Huang,Jian, AU - Sun,Bo-Hang, AU - Wu,Li-Jun, PY - 2010/4/15/entrez PY - 2010/4/15/pubmed PY - 2010/5/11/medline SP - 144 EP - 9 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 12 IS - 2 N2 - In the screening of biologically active constituents from medicinal plants, the 75% EtOH extract of the testas of Castanea mollissima Blume showed potent alpha-glucosidase inhibitory activity. By means of various chromatographic methods, the extract gave a new dammarane-type triterpene 1 along with 17 known compounds. The structure of 1 was determined to be 3beta-acetoxy-20-oxo-21-nordammaran-23-oic acid by HRMS and NMR studies including 2D NMR experiments. The new compound and some known compounds showed potent alpha-glucosidase inhibitory activity with acarbose as a positive control. SN - 1477-2213 UR - https://www.unboundmedicine.com/medline/citation/20390758/Constituents_from_the_testas_of_Castanea_mollissima_Blume_with_alpha_glucosidase_inhibitory_activity_ L2 - https://www.tandfonline.com/doi/full/10.1080/10286020903451757 DB - PRIME DP - Unbound Medicine ER -