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Ozone increases airway hyperreactivity and mucus hyperproduction in mice previously exposed to allergen.
J Toxicol Environ Health A. 2010; 73(11):738-47.JT

Abstract

Acute exacerbations of asthma represent a common clinical problem with major economic impact. Air pollutants including ozone have been shown to contribute to asthma exacerbation, but the mechanisms underlying ozone-induced asthma exacerbation are only partially understood. The present study aimed to develop a mouse model to gain insight into the development of airway hyperresponsiveness (AHR) to methacholine (MCh) in mice after exposure to both allergen and ozone. Mice were exposed for 20 min per day for 10 consecutive days to an aerosol of 1% ovalbumin (OVA) or saline followed by a single 3-h exposure to clean air or 100, 250, or 500 ppb ozone. Ozone induced AHR in mice previously exposed to OVA when compared to non-exposed (saline) control mice. After a 10-d exposure to OVA, a single exposure to a low (100 ppb) ozone concentration was sufficient to induce AHR. The AHR response was associated with goblet-cell metaplasia. Even the lowest concentration of ozone tested, 100 ppb, which may be exceeded in urban environments and in the workplace, resulted in a significant increase in AHR, most prominent 24 h after exposure in the OVA-exposed mice.

Authors+Show Affiliations

Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20391116

Citation

Larsen, Søren T., et al. "Ozone Increases Airway Hyperreactivity and Mucus Hyperproduction in Mice Previously Exposed to Allergen." Journal of Toxicology and Environmental Health. Part A, vol. 73, no. 11, 2010, pp. 738-47.
Larsen ST, Matsubara S, McConville G, et al. Ozone increases airway hyperreactivity and mucus hyperproduction in mice previously exposed to allergen. J Toxicol Environ Health Part A. 2010;73(11):738-47.
Larsen, S. T., Matsubara, S., McConville, G., Poulsen, S. S., & Gelfand, E. W. (2010). Ozone increases airway hyperreactivity and mucus hyperproduction in mice previously exposed to allergen. Journal of Toxicology and Environmental Health. Part A, 73(11), 738-47. https://doi.org/10.1080/15287391003614034
Larsen ST, et al. Ozone Increases Airway Hyperreactivity and Mucus Hyperproduction in Mice Previously Exposed to Allergen. J Toxicol Environ Health Part A. 2010;73(11):738-47. PubMed PMID: 20391116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ozone increases airway hyperreactivity and mucus hyperproduction in mice previously exposed to allergen. AU - Larsen,Søren T, AU - Matsubara,Shigeki, AU - McConville,Glen, AU - Poulsen,Steen S, AU - Gelfand,Erwin W, PY - 2010/4/15/entrez PY - 2010/4/15/pubmed PY - 2010/4/30/medline SP - 738 EP - 47 JF - Journal of toxicology and environmental health. Part A JO - J. Toxicol. Environ. Health Part A VL - 73 IS - 11 N2 - Acute exacerbations of asthma represent a common clinical problem with major economic impact. Air pollutants including ozone have been shown to contribute to asthma exacerbation, but the mechanisms underlying ozone-induced asthma exacerbation are only partially understood. The present study aimed to develop a mouse model to gain insight into the development of airway hyperresponsiveness (AHR) to methacholine (MCh) in mice after exposure to both allergen and ozone. Mice were exposed for 20 min per day for 10 consecutive days to an aerosol of 1% ovalbumin (OVA) or saline followed by a single 3-h exposure to clean air or 100, 250, or 500 ppb ozone. Ozone induced AHR in mice previously exposed to OVA when compared to non-exposed (saline) control mice. After a 10-d exposure to OVA, a single exposure to a low (100 ppb) ozone concentration was sufficient to induce AHR. The AHR response was associated with goblet-cell metaplasia. Even the lowest concentration of ozone tested, 100 ppb, which may be exceeded in urban environments and in the workplace, resulted in a significant increase in AHR, most prominent 24 h after exposure in the OVA-exposed mice. SN - 1528-7394 UR - https://www.unboundmedicine.com/medline/citation/20391116/Ozone_increases_airway_hyperreactivity_and_mucus_hyperproduction_in_mice_previously_exposed_to_allergen_ L2 - http://www.tandfonline.com/doi/full/10.1080/15287391003614034 DB - PRIME DP - Unbound Medicine ER -