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Breast-feeding in relation to asthma, lung function, and sensitization in young schoolchildren.
J Allergy Clin Immunol. 2010 May; 125(5):1013-9.JA

Abstract

BACKGROUND

The evidence from previous studies on beneficial effects of breast-feeding in relation to development of asthma is conflicting.

OBJECTIVE

To investigate the relation between breast-feeding and asthma and/or sensitization during the first 8 years of life.

METHOD

In a birth cohort, children were followed up to 8 years by questionnaires at ages 2 months and 1, 2, 4, and 8 years to collect information on exposures and health effects. Determination of serum IgE antibodies to common inhalant and food allergens was performed at 4 and 8 years. Longitudinal analyses were applied by using general estimated equations. The study population consisted of 3825 children (93% of the original cohort), of whom 2370 gave blood and 2564 performed lung function measurements at 8 years.

RESULTS

Children exclusively breast-fed 4 months or more had a reduced risk of asthma during the first 8 years of life (adjusted odds ratio [OR], 0.63; 95% CI, 0.50-0.78) compared with children breast-fed less than 4 months. At 8 years, reduced risks of sensitization (adjusted OR, 0.79; 95% CI, 0.64-0.99) and asthma in combination with sensitization (adjusted OR, 0.59; 95% CI, 0.37-0.93) were seen among children exclusively breast-fed 4 months or more. This group also had a significantly better lung function measured with peak expiratory flow.

CONCLUSION

Breast-feeding for 4 months or more seems to reduce the risk of asthma up to 8 years. At this age, a reduced risk was observed particularly for asthma combined with sensitization. Furthermore, breast-feeding seems to have a beneficial effect on lung function.

Authors+Show Affiliations

Institute of Environmental Medicine, Karolinska Institutet, SE-171 76 Stockholm, Sweden. inger.kull@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20392479

Citation

Kull, Inger, et al. "Breast-feeding in Relation to Asthma, Lung Function, and Sensitization in Young Schoolchildren." The Journal of Allergy and Clinical Immunology, vol. 125, no. 5, 2010, pp. 1013-9.
Kull I, Melen E, Alm J, et al. Breast-feeding in relation to asthma, lung function, and sensitization in young schoolchildren. J Allergy Clin Immunol. 2010;125(5):1013-9.
Kull, I., Melen, E., Alm, J., Hallberg, J., Svartengren, M., van Hage, M., Pershagen, G., Wickman, M., & Bergström, A. (2010). Breast-feeding in relation to asthma, lung function, and sensitization in young schoolchildren. The Journal of Allergy and Clinical Immunology, 125(5), 1013-9. https://doi.org/10.1016/j.jaci.2010.01.051
Kull I, et al. Breast-feeding in Relation to Asthma, Lung Function, and Sensitization in Young Schoolchildren. J Allergy Clin Immunol. 2010;125(5):1013-9. PubMed PMID: 20392479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast-feeding in relation to asthma, lung function, and sensitization in young schoolchildren. AU - Kull,Inger, AU - Melen,Erik, AU - Alm,Johan, AU - Hallberg,Jenny, AU - Svartengren,Magnus, AU - van Hage,Marianne, AU - Pershagen,Göran, AU - Wickman,Magnus, AU - Bergström,Anna, Y1 - 2010/04/14/ PY - 2009/07/15/received PY - 2010/01/05/revised PY - 2010/01/19/accepted PY - 2010/4/16/entrez PY - 2010/4/16/pubmed PY - 2010/6/22/medline SP - 1013 EP - 9 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 125 IS - 5 N2 - BACKGROUND: The evidence from previous studies on beneficial effects of breast-feeding in relation to development of asthma is conflicting. OBJECTIVE: To investigate the relation between breast-feeding and asthma and/or sensitization during the first 8 years of life. METHOD: In a birth cohort, children were followed up to 8 years by questionnaires at ages 2 months and 1, 2, 4, and 8 years to collect information on exposures and health effects. Determination of serum IgE antibodies to common inhalant and food allergens was performed at 4 and 8 years. Longitudinal analyses were applied by using general estimated equations. The study population consisted of 3825 children (93% of the original cohort), of whom 2370 gave blood and 2564 performed lung function measurements at 8 years. RESULTS: Children exclusively breast-fed 4 months or more had a reduced risk of asthma during the first 8 years of life (adjusted odds ratio [OR], 0.63; 95% CI, 0.50-0.78) compared with children breast-fed less than 4 months. At 8 years, reduced risks of sensitization (adjusted OR, 0.79; 95% CI, 0.64-0.99) and asthma in combination with sensitization (adjusted OR, 0.59; 95% CI, 0.37-0.93) were seen among children exclusively breast-fed 4 months or more. This group also had a significantly better lung function measured with peak expiratory flow. CONCLUSION: Breast-feeding for 4 months or more seems to reduce the risk of asthma up to 8 years. At this age, a reduced risk was observed particularly for asthma combined with sensitization. Furthermore, breast-feeding seems to have a beneficial effect on lung function. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/20392479/Breast_feeding_in_relation_to_asthma_lung_function_and_sensitization_in_young_schoolchildren_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(10)00203-4 DB - PRIME DP - Unbound Medicine ER -