Tags

Type your tag names separated by a space and hit enter

Comparative effects of pimecrolimus cream vehicle and three commercially available moisturizers on skin hydration and transepidermal water loss.
J Dermatolog Treat. 2010 May; 21(3):126-9.JD

Abstract

BACKGROUND

Hydration and integrity of the horny layer is essential to normal skin function.

OBJECTIVE

Comparison of the hydrating properties of three moisturizers with pimecrolimus cream vehicle.

METHODS

Four test preparations (high-quality skin cream, cold cream emulsion, emollient oil, pimecrolimus cream vehicle) were applied to four different regions of the forearms and legs. Transepidermal water loss (TEWL) was assessed by evaporimetry at baseline, and 3 and 6 hours after arm application, and electrical capacitance was assessed by corneometry at baseline, and 1, 2, 3 and 6 hours after leg application.

RESULTS

Corneometry assessment - in terms of efficacy in moisturizing the skin, test preparations were ranked (best to worst): high-quality skin cream (45.9 arbitrary units versus 75.3; p < 0.001) > pimecrolimus vehicle cream (46.6 versus 61.5; p < 0.001) > emollient oil (43.5 versus 54.8; p = 0.006) > cold cream emulsion (44.8 versus 49.9; p = 0.738). Untreated skin (control) had a mean capacitance of 44.8 units at baseline and 48.5 units at endpoint. Evaporimetry (assessment of TEWL) revealed no significant differences between control and any test preparation at any timepoint.

CONCLUSIONS

Pimecrolimus cream vehicle has skin hydration properties comparable with highly effective commercially available products. No test preparation had a significant effect on TEWL.

Authors+Show Affiliations

Department of Dermatology, UNICAMP Campinas, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20394488

Citation

Vergnanini, André L., et al. "Comparative Effects of Pimecrolimus Cream Vehicle and Three Commercially Available Moisturizers On Skin Hydration and Transepidermal Water Loss." The Journal of Dermatological Treatment, vol. 21, no. 3, 2010, pp. 126-9.
Vergnanini AL, Aoki V, Takaoka R, et al. Comparative effects of pimecrolimus cream vehicle and three commercially available moisturizers on skin hydration and transepidermal water loss. J Dermatolog Treat. 2010;21(3):126-9.
Vergnanini, A. L., Aoki, V., Takaoka, R., & Madi, J. (2010). Comparative effects of pimecrolimus cream vehicle and three commercially available moisturizers on skin hydration and transepidermal water loss. The Journal of Dermatological Treatment, 21(3), 126-9. https://doi.org/10.3109/09546630903188403
Vergnanini AL, et al. Comparative Effects of Pimecrolimus Cream Vehicle and Three Commercially Available Moisturizers On Skin Hydration and Transepidermal Water Loss. J Dermatolog Treat. 2010;21(3):126-9. PubMed PMID: 20394488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative effects of pimecrolimus cream vehicle and three commercially available moisturizers on skin hydration and transepidermal water loss. AU - Vergnanini,André L, AU - Aoki,Valeria, AU - Takaoka,Roberto, AU - Madi,Julio, PY - 2010/4/17/entrez PY - 2010/4/17/pubmed PY - 2010/7/28/medline SP - 126 EP - 9 JF - The Journal of dermatological treatment JO - J Dermatolog Treat VL - 21 IS - 3 N2 - BACKGROUND: Hydration and integrity of the horny layer is essential to normal skin function. OBJECTIVE: Comparison of the hydrating properties of three moisturizers with pimecrolimus cream vehicle. METHODS: Four test preparations (high-quality skin cream, cold cream emulsion, emollient oil, pimecrolimus cream vehicle) were applied to four different regions of the forearms and legs. Transepidermal water loss (TEWL) was assessed by evaporimetry at baseline, and 3 and 6 hours after arm application, and electrical capacitance was assessed by corneometry at baseline, and 1, 2, 3 and 6 hours after leg application. RESULTS: Corneometry assessment - in terms of efficacy in moisturizing the skin, test preparations were ranked (best to worst): high-quality skin cream (45.9 arbitrary units versus 75.3; p < 0.001) > pimecrolimus vehicle cream (46.6 versus 61.5; p < 0.001) > emollient oil (43.5 versus 54.8; p = 0.006) > cold cream emulsion (44.8 versus 49.9; p = 0.738). Untreated skin (control) had a mean capacitance of 44.8 units at baseline and 48.5 units at endpoint. Evaporimetry (assessment of TEWL) revealed no significant differences between control and any test preparation at any timepoint. CONCLUSIONS: Pimecrolimus cream vehicle has skin hydration properties comparable with highly effective commercially available products. No test preparation had a significant effect on TEWL. SN - 1471-1753 UR - https://www.unboundmedicine.com/medline/citation/20394488/Comparative_effects_of_pimecrolimus_cream_vehicle_and_three_commercially_available_moisturizers_on_skin_hydration_and_transepidermal_water_loss_ L2 - https://www.tandfonline.com/doi/full/10.3109/09546630903188403 DB - PRIME DP - Unbound Medicine ER -