Tags

Type your tag names separated by a space and hit enter

Fear-potentiated startle, but not light-enhanced startle, is enhanced by anxiogenic drugs.
Pharmacol Biochem Behav. 2010 Jul; 96(1):24-31.PB

Abstract

RATIONALE AND OBJECTIVES

The light-enhanced startle paradigm (LES) is suggested to model anxiety, because of the non-specific cue and the long-term effect. In contrast, the fear-potentiated startle (FPS) is suggested to model conditioned fear. However, the pharmacological profiles of these two paradigms are very similar. The present study investigated the effects of putative anxiogenic drugs on LES and FPS and aimed at determining the sensitivity of LES for anxiogenic drugs and to potentially showing a pharmacological differentiation between these two paradigms.

METHODS

Male Wistar rats received each dose of the alpha(2)-adrenoceptor antagonist yohimbine (0.25-1.0mg/kg), the 5-HT(2C) receptor agonist m-chlorophenylpiperazine (mCPP, 0.5-2.0mg/kg) or the GABA(A) inverse receptor agonist pentylenetetrazole (PTZ, 3-30mg/kg) and were subsequently tested in either LES or FPS.

RESULTS

None of the drugs enhanced LES, whereas mCPP increased percentage FPS and yohimbine increased absolute FPS values. Furthermore, yohimbine increased baseline startle amplitude in the LES, while mCPP suppressed baseline startle in both the LES and FPS and PTZ suppressed baseline startle in the FPS.

CONCLUSIONS

In contrast to findings in the FPS paradigm, none of the drugs were able to exacerbate the LES response. Thus, a clear pharmacological differentiation was found between LES and FPS.

Authors+Show Affiliations

Section Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands. E.Y.Bijlsma@uu.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20394767

Citation

Bijlsma, Elisabeth Yvonne, et al. "Fear-potentiated Startle, but Not Light-enhanced Startle, Is Enhanced By Anxiogenic Drugs." Pharmacology, Biochemistry, and Behavior, vol. 96, no. 1, 2010, pp. 24-31.
Bijlsma EY, de Jongh R, Olivier B, et al. Fear-potentiated startle, but not light-enhanced startle, is enhanced by anxiogenic drugs. Pharmacol Biochem Behav. 2010;96(1):24-31.
Bijlsma, E. Y., de Jongh, R., Olivier, B., & Groenink, L. (2010). Fear-potentiated startle, but not light-enhanced startle, is enhanced by anxiogenic drugs. Pharmacology, Biochemistry, and Behavior, 96(1), 24-31. https://doi.org/10.1016/j.pbb.2010.04.002
Bijlsma EY, et al. Fear-potentiated Startle, but Not Light-enhanced Startle, Is Enhanced By Anxiogenic Drugs. Pharmacol Biochem Behav. 2010;96(1):24-31. PubMed PMID: 20394767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fear-potentiated startle, but not light-enhanced startle, is enhanced by anxiogenic drugs. AU - Bijlsma,Elisabeth Yvonne, AU - de Jongh,Reinoud, AU - Olivier,Berend, AU - Groenink,Lucianne, Y1 - 2010/04/13/ PY - 2009/08/31/received PY - 2010/02/16/revised PY - 2010/04/06/accepted PY - 2010/4/17/entrez PY - 2010/4/17/pubmed PY - 2011/2/24/medline SP - 24 EP - 31 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 96 IS - 1 N2 - RATIONALE AND OBJECTIVES: The light-enhanced startle paradigm (LES) is suggested to model anxiety, because of the non-specific cue and the long-term effect. In contrast, the fear-potentiated startle (FPS) is suggested to model conditioned fear. However, the pharmacological profiles of these two paradigms are very similar. The present study investigated the effects of putative anxiogenic drugs on LES and FPS and aimed at determining the sensitivity of LES for anxiogenic drugs and to potentially showing a pharmacological differentiation between these two paradigms. METHODS: Male Wistar rats received each dose of the alpha(2)-adrenoceptor antagonist yohimbine (0.25-1.0mg/kg), the 5-HT(2C) receptor agonist m-chlorophenylpiperazine (mCPP, 0.5-2.0mg/kg) or the GABA(A) inverse receptor agonist pentylenetetrazole (PTZ, 3-30mg/kg) and were subsequently tested in either LES or FPS. RESULTS: None of the drugs enhanced LES, whereas mCPP increased percentage FPS and yohimbine increased absolute FPS values. Furthermore, yohimbine increased baseline startle amplitude in the LES, while mCPP suppressed baseline startle in both the LES and FPS and PTZ suppressed baseline startle in the FPS. CONCLUSIONS: In contrast to findings in the FPS paradigm, none of the drugs were able to exacerbate the LES response. Thus, a clear pharmacological differentiation was found between LES and FPS. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/20394767/Fear_potentiated_startle_but_not_light_enhanced_startle_is_enhanced_by_anxiogenic_drugs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(10)00097-3 DB - PRIME DP - Unbound Medicine ER -