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Oxidized high-density lipoprotein is associated with protein-energy wasting in maintenance hemodialysis patients.
Clin J Am Soc Nephrol. 2010 Jun; 5(6):1021-8.CJ

Abstract

BACKGROUND AND OBJECTIVES

Oxidized HDL (oxHDL) may behave as proinflammatory HDL because of reduced anti-inflammatory capacity and is considered a risk factor for mortality in patients on maintenance hemodialysis (MHD). The study presented here assessed the effect of oxHDL on protein-energy wasting (PEW) in MHD patients.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS

This prospective study examined a cohort of MHD patients (n = 176) who were not taking lipid-lowering drugs. Blood samples were obtained to measure albumin, lipids, high-sensitivity C-reactive protein (hsCRP), oxidized LDL (oxLDL), and oxHDL. PEW was assessed by subjective global assessment (SGA) and geriatric nutritional risk index (GNRI). Measurements and assessment of nutritional status were followed up 1 year later.

RESULTS

OxHDL was significantly increased in patients with PEW at baseline. High oxHDL and high hsCRP were significantly associated with PEW, and receiver operating characteristic curves for oxHDL and hsCRP showed statistically similar accuracy for predicting SGA-positive status. According to multivariate regression models, high oxHDL had a significant influence on PEW in patients, particularly those with high hsCRP. Decreased changes in GNRI and high prevalence of SGA-positive status at 1 year were more common in patients with high oxHDL at baseline and 1 year later than in patients with low oxHDL at both time points.

CONCLUSIONS

A high oxHDL state may be associated with PEW estimated by GNRI and SGA, particularly concomitant with inflammation in MHD patients.

Authors+Show Affiliations

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan. hondah@med.showa-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

20395357

Citation

Honda, Hirokazu, et al. "Oxidized High-density Lipoprotein Is Associated With Protein-energy Wasting in Maintenance Hemodialysis Patients." Clinical Journal of the American Society of Nephrology : CJASN, vol. 5, no. 6, 2010, pp. 1021-8.
Honda H, Ueda M, Kojima S, et al. Oxidized high-density lipoprotein is associated with protein-energy wasting in maintenance hemodialysis patients. Clin J Am Soc Nephrol. 2010;5(6):1021-8.
Honda, H., Ueda, M., Kojima, S., Mashiba, S., Suzuki, H., Hosaka, N., Hirai, Y., Nakamura, M., Nagai, H., Kato, N., Mukai, M., Watanabe, M., Takahashi, K., Shishido, K., & Akizawa, T. (2010). Oxidized high-density lipoprotein is associated with protein-energy wasting in maintenance hemodialysis patients. Clinical Journal of the American Society of Nephrology : CJASN, 5(6), 1021-8. https://doi.org/10.2215/CJN.06110809
Honda H, et al. Oxidized High-density Lipoprotein Is Associated With Protein-energy Wasting in Maintenance Hemodialysis Patients. Clin J Am Soc Nephrol. 2010;5(6):1021-8. PubMed PMID: 20395357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidized high-density lipoprotein is associated with protein-energy wasting in maintenance hemodialysis patients. AU - Honda,Hirokazu, AU - Ueda,Masashi, AU - Kojima,Shiho, AU - Mashiba,Shinichi, AU - Suzuki,Hiroki, AU - Hosaka,Nozomu, AU - Hirai,Yuki, AU - Nakamura,Mari, AU - Nagai,Hisako, AU - Kato,Noriyuki, AU - Mukai,Masanori, AU - Watanabe,Makoto, AU - Takahashi,Keiko, AU - Shishido,Kanji, AU - Akizawa,Tadao, Y1 - 2010/04/15/ PY - 2010/4/17/entrez PY - 2010/4/17/pubmed PY - 2010/9/21/medline SP - 1021 EP - 8 JF - Clinical journal of the American Society of Nephrology : CJASN JO - Clin J Am Soc Nephrol VL - 5 IS - 6 N2 - BACKGROUND AND OBJECTIVES: Oxidized HDL (oxHDL) may behave as proinflammatory HDL because of reduced anti-inflammatory capacity and is considered a risk factor for mortality in patients on maintenance hemodialysis (MHD). The study presented here assessed the effect of oxHDL on protein-energy wasting (PEW) in MHD patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This prospective study examined a cohort of MHD patients (n = 176) who were not taking lipid-lowering drugs. Blood samples were obtained to measure albumin, lipids, high-sensitivity C-reactive protein (hsCRP), oxidized LDL (oxLDL), and oxHDL. PEW was assessed by subjective global assessment (SGA) and geriatric nutritional risk index (GNRI). Measurements and assessment of nutritional status were followed up 1 year later. RESULTS: OxHDL was significantly increased in patients with PEW at baseline. High oxHDL and high hsCRP were significantly associated with PEW, and receiver operating characteristic curves for oxHDL and hsCRP showed statistically similar accuracy for predicting SGA-positive status. According to multivariate regression models, high oxHDL had a significant influence on PEW in patients, particularly those with high hsCRP. Decreased changes in GNRI and high prevalence of SGA-positive status at 1 year were more common in patients with high oxHDL at baseline and 1 year later than in patients with low oxHDL at both time points. CONCLUSIONS: A high oxHDL state may be associated with PEW estimated by GNRI and SGA, particularly concomitant with inflammation in MHD patients. SN - 1555-905X UR - https://www.unboundmedicine.com/medline/citation/20395357/Oxidized_high_density_lipoprotein_is_associated_with_protein_energy_wasting_in_maintenance_hemodialysis_patients_ L2 - https://cjasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=20395357 DB - PRIME DP - Unbound Medicine ER -