Tags

Type your tag names separated by a space and hit enter

High absolute coronary disease risk among Turks: involvement of risk factors additional to conventional ones.
Cardiology. 2010; 115(4):297-306.C

Abstract

OBJECTIVES

To confirm previous findings on excess absolute coronary heart disease (CHD) risk among Turks.

METHODS

The observed incident CHD risk of a representative population sample was compared with that anticipated by Framingham risk scores (FRS). At 7.4 years of follow-up of 3,027 participants free of CHD at baseline, risk estimation was contrasted in the 398 cases of newly developed fatal and nonfatal CHD.

RESULTS

CHD developed at a rate 2.2 times higher than the anticipated risk. In sex-specific quintiles of FRS, the 10-year incidence of CHD events in males in the 2 highest quintiles was 2 times the anticipated levels. In women, the 3 highest quintiles displayed an incidence 2.7 times the anticipated risk. Such individuals typically had abdominal obesity and evidence of dysfunctional apolipoprotein (apo) A-I. Men had high levels of non-high-density lipoprotein (HDL) cholesterol, total apoC-III, apoB and triglycerides. In Cox proportional hazard regression analyses, the 10-year probability of remaining free of CHD was low (81.1% in men, 84.2% in women). Women exhibited C-reactive protein as an independent predictor of CHD, lack of protection by HDL cholesterol and no conferred risk from current smoking. The observed excess CHD risk was primarily attributed to central obesity and related dysfunction of HDL, apoC-III and apoA-I.

CONCLUSION

Dysfunction of protective serum proteins associated with metabolic syndrome impacts on CHD events, in addition to conventional risk factors.

Authors+Show Affiliations

Turkish Society of Cardiology, Istanbul, Turkey. alt_onat@yahoo.com.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20395681

Citation

Onat, Altan, et al. "High Absolute Coronary Disease Risk Among Turks: Involvement of Risk Factors Additional to Conventional Ones." Cardiology, vol. 115, no. 4, 2010, pp. 297-306.
Onat A, Can G, Hergenç G, et al. High absolute coronary disease risk among Turks: involvement of risk factors additional to conventional ones. Cardiology. 2010;115(4):297-306.
Onat, A., Can, G., Hergenç, G., Küçükdurmaz, Z., Uğur, M., & Yüksel, H. (2010). High absolute coronary disease risk among Turks: involvement of risk factors additional to conventional ones. Cardiology, 115(4), 297-306. https://doi.org/10.1159/000312009
Onat A, et al. High Absolute Coronary Disease Risk Among Turks: Involvement of Risk Factors Additional to Conventional Ones. Cardiology. 2010;115(4):297-306. PubMed PMID: 20395681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High absolute coronary disease risk among Turks: involvement of risk factors additional to conventional ones. AU - Onat,Altan, AU - Can,Günay, AU - Hergenç,Gülay, AU - Küçükdurmaz,Zekeriya, AU - Uğur,Murat, AU - Yüksel,Hüsniye, Y1 - 2010/04/16/ PY - 2009/12/08/received PY - 2010/01/31/accepted PY - 2010/4/17/entrez PY - 2010/4/17/pubmed PY - 2010/7/22/medline SP - 297 EP - 306 JF - Cardiology JO - Cardiology VL - 115 IS - 4 N2 - OBJECTIVES: To confirm previous findings on excess absolute coronary heart disease (CHD) risk among Turks. METHODS: The observed incident CHD risk of a representative population sample was compared with that anticipated by Framingham risk scores (FRS). At 7.4 years of follow-up of 3,027 participants free of CHD at baseline, risk estimation was contrasted in the 398 cases of newly developed fatal and nonfatal CHD. RESULTS: CHD developed at a rate 2.2 times higher than the anticipated risk. In sex-specific quintiles of FRS, the 10-year incidence of CHD events in males in the 2 highest quintiles was 2 times the anticipated levels. In women, the 3 highest quintiles displayed an incidence 2.7 times the anticipated risk. Such individuals typically had abdominal obesity and evidence of dysfunctional apolipoprotein (apo) A-I. Men had high levels of non-high-density lipoprotein (HDL) cholesterol, total apoC-III, apoB and triglycerides. In Cox proportional hazard regression analyses, the 10-year probability of remaining free of CHD was low (81.1% in men, 84.2% in women). Women exhibited C-reactive protein as an independent predictor of CHD, lack of protection by HDL cholesterol and no conferred risk from current smoking. The observed excess CHD risk was primarily attributed to central obesity and related dysfunction of HDL, apoC-III and apoA-I. CONCLUSION: Dysfunction of protective serum proteins associated with metabolic syndrome impacts on CHD events, in addition to conventional risk factors. SN - 1421-9751 UR - https://www.unboundmedicine.com/medline/citation/20395681/High_absolute_coronary_disease_risk_among_Turks:_involvement_of_risk_factors_additional_to_conventional_ones_ L2 - https://www.karger.com?DOI=10.1159/000312009 DB - PRIME DP - Unbound Medicine ER -