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Interactions between specific parameters of cannabis use and verbal memory.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16; 34(6):871-6.PN

Abstract

Recently, the impact of different parameters of cannabis use, including the age of first use, the average frequency of use, the cumulative lifetime dose, the average dose per occasion, and the duration of regular use upon cognitive functions has been discussed. However, to date no study has systematically investigated the interactions of these parameters with regard to cognitive performance. To determine whether these interactions exist, 142 healthy young adult cannabis users participated in a neuropsychological assessment study with a German version of the Rey Auditory Verbal Learning Test (RAVLT). In line with previous studies on cannabis use and verbal memory, significant associations between certain components of verbal memory and frequency of use, cumulative lifetime dose and duration of regular use respectively were found. Remarkably, a multivariate analysis solely revealed a significant main effect of the duration of cannabis use with regard to immediate recall and recall after interference. Moreover, the findings suggest that age of first use, duration of use and frequency of cannabis use interact with regard to their impact on different measures of verbal memory. The findings of the present study provide first evidence that particular parameters of cannabis use interact with regard to their impact on cognitive functions in unintoxicated cannabis users. This finding might deliver more insight into the complex mechanisms underlying the impaired memory functions observed in cannabis users.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20398718

Citation

Wagner, Daniel, et al. "Interactions Between Specific Parameters of Cannabis Use and Verbal Memory." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 34, no. 6, 2010, pp. 871-6.
Wagner D, Becker B, Gouzoulis-Mayfrank E, et al. Interactions between specific parameters of cannabis use and verbal memory. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(6):871-6.
Wagner, D., Becker, B., Gouzoulis-Mayfrank, E., & Daumann, J. (2010). Interactions between specific parameters of cannabis use and verbal memory. Progress in Neuro-psychopharmacology & Biological Psychiatry, 34(6), 871-6. https://doi.org/10.1016/j.pnpbp.2010.04.004
Wagner D, et al. Interactions Between Specific Parameters of Cannabis Use and Verbal Memory. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):871-6. PubMed PMID: 20398718.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interactions between specific parameters of cannabis use and verbal memory. AU - Wagner,Daniel, AU - Becker,Benjamin, AU - Gouzoulis-Mayfrank,Euphrosyne, AU - Daumann,Jörg, Y1 - 2010/04/14/ PY - 2010/01/29/received PY - 2010/03/18/revised PY - 2010/04/07/accepted PY - 2010/4/20/entrez PY - 2010/4/20/pubmed PY - 2010/11/3/medline SP - 871 EP - 6 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 34 IS - 6 N2 - Recently, the impact of different parameters of cannabis use, including the age of first use, the average frequency of use, the cumulative lifetime dose, the average dose per occasion, and the duration of regular use upon cognitive functions has been discussed. However, to date no study has systematically investigated the interactions of these parameters with regard to cognitive performance. To determine whether these interactions exist, 142 healthy young adult cannabis users participated in a neuropsychological assessment study with a German version of the Rey Auditory Verbal Learning Test (RAVLT). In line with previous studies on cannabis use and verbal memory, significant associations between certain components of verbal memory and frequency of use, cumulative lifetime dose and duration of regular use respectively were found. Remarkably, a multivariate analysis solely revealed a significant main effect of the duration of cannabis use with regard to immediate recall and recall after interference. Moreover, the findings suggest that age of first use, duration of use and frequency of cannabis use interact with regard to their impact on different measures of verbal memory. The findings of the present study provide first evidence that particular parameters of cannabis use interact with regard to their impact on cognitive functions in unintoxicated cannabis users. This finding might deliver more insight into the complex mechanisms underlying the impaired memory functions observed in cannabis users. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/20398718/Interactions_between_specific_parameters_of_cannabis_use_and_verbal_memory_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(10)00133-8 DB - PRIME DP - Unbound Medicine ER -