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The transition metals copper and iron in neurodegenerative diseases.
Chem Biol Interact 2010; 186(2):184-99CB

Abstract

Neurodegenerative diseases constitute a worldwide health problem. Metals like iron and copper are essential for life, but they are also involved in several neurodegenerative mechanisms such as protein aggregation, free radical generation and oxidative stress. The role of Fe and Cu, their pathogenic mechanisms and possible therapeutic relevance are discussed regarding four of the most common neurodegenerative diseases, Alzheimer's, Parkinson's and Huntington's diseases as well as amyotrophic lateral sclerosis. Metal-mediated oxidation by Fenton chemistry is a common feature for all those disorders and takes part of a self-amplifying damaging mechanism, leading to neurodegeneration. The interaction between metals and proteins in the nervous system seems to be a crucial factor for the development or absence of neurodegeneration. The present review also deals with the therapeutic strategies tested, mainly using metal chelating drugs. Metal accumulation within the nervous system observed in those diseases could be the result of compensatory mechanisms to improve metal availability for physiological processes.

Authors+Show Affiliations

Neurochemistry Department, National Institute of Neurology and Neurosurgery Manuel Velasco Suárez, Mexico City, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20399203

Citation

Rivera-Mancía, Susana, et al. "The Transition Metals Copper and Iron in Neurodegenerative Diseases." Chemico-biological Interactions, vol. 186, no. 2, 2010, pp. 184-99.
Rivera-Mancía S, Pérez-Neri I, Ríos C, et al. The transition metals copper and iron in neurodegenerative diseases. Chem Biol Interact. 2010;186(2):184-99.
Rivera-Mancía, S., Pérez-Neri, I., Ríos, C., Tristán-López, L., Rivera-Espinosa, L., & Montes, S. (2010). The transition metals copper and iron in neurodegenerative diseases. Chemico-biological Interactions, 186(2), pp. 184-99. doi:10.1016/j.cbi.2010.04.010.
Rivera-Mancía S, et al. The Transition Metals Copper and Iron in Neurodegenerative Diseases. Chem Biol Interact. 2010 Jul 30;186(2):184-99. PubMed PMID: 20399203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The transition metals copper and iron in neurodegenerative diseases. AU - Rivera-Mancía,Susana, AU - Pérez-Neri,Iván, AU - Ríos,Camilo, AU - Tristán-López,Luis, AU - Rivera-Espinosa,Liliana, AU - Montes,Sergio, Y1 - 2010/05/14/ PY - 2009/09/28/received PY - 2010/01/22/revised PY - 2010/04/08/accepted PY - 2010/4/20/entrez PY - 2010/4/20/pubmed PY - 2010/7/2/medline SP - 184 EP - 99 JF - Chemico-biological interactions JO - Chem. Biol. Interact. VL - 186 IS - 2 N2 - Neurodegenerative diseases constitute a worldwide health problem. Metals like iron and copper are essential for life, but they are also involved in several neurodegenerative mechanisms such as protein aggregation, free radical generation and oxidative stress. The role of Fe and Cu, their pathogenic mechanisms and possible therapeutic relevance are discussed regarding four of the most common neurodegenerative diseases, Alzheimer's, Parkinson's and Huntington's diseases as well as amyotrophic lateral sclerosis. Metal-mediated oxidation by Fenton chemistry is a common feature for all those disorders and takes part of a self-amplifying damaging mechanism, leading to neurodegeneration. The interaction between metals and proteins in the nervous system seems to be a crucial factor for the development or absence of neurodegeneration. The present review also deals with the therapeutic strategies tested, mainly using metal chelating drugs. Metal accumulation within the nervous system observed in those diseases could be the result of compensatory mechanisms to improve metal availability for physiological processes. SN - 1872-7786 UR - https://www.unboundmedicine.com/medline/citation/20399203/The_transition_metals_copper_and_iron_in_neurodegenerative_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(10)00271-1 DB - PRIME DP - Unbound Medicine ER -