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Chronic sugar intake dampens feeding-related activity of neurons synthesizing a satiety mediator, oxytocin.
Peptides 2010; 31(7):1346-52P

Abstract

Increased tone of orexigens mediating reward occurs upon repeated consumption of sweet foods. Interestingly, some of these reward orexigens, such as opioids, diminish activity of neurons synthesizing oxytocin, a nonapeptide that promotes satiety and feeding termination. It is not known, however, whether consumption-related activity of the central oxytocin system is modified under chronic sugar feeding reward itself. Therefore, we examined how chronic consumption of a rewarding high-sucrose (HS) vs. bland cornstarch (CS) diet affected the activity of oxytocin cells in the hypothalamus at the time of meal termination. Schedule-fed (2h/day) rats received either a HS or CS powdered diet for 20 days. On the 21st day, they were given the same or the opposite diet, and food was removed after the main consummatory activity was completed. Animals were perfused 60 min after feeding termination and brains were immunostained for oxytocin and the marker of neuronal activity, c-Fos. The percentage of c-Fos-positive oxytocin cells in the hypothalamic paraventricular nucleus was significantly lower in rats chronically exposed to the HS than to the CS diet, regardless of which diet they received on the final day. A similar pattern was observed in the supraoptic nucleus. We conclude that the chronic rather than acute sucrose intake reduces activity of the anorexigenic oxytocin system. These findings indicate that chronic consumption of sugar blunts activity of pathways that mediate satiety. We speculate that a reduction in central satiety signaling precipitated by regular intake of foods high in sugar may lead to generalized overeating.

Authors+Show Affiliations

Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave., St. Paul, MN 55108, USA. amitra@umn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20399242

Citation

Mitra, Anaya, et al. "Chronic Sugar Intake Dampens Feeding-related Activity of Neurons Synthesizing a Satiety Mediator, Oxytocin." Peptides, vol. 31, no. 7, 2010, pp. 1346-52.
Mitra A, Gosnell BA, Schiöth HB, et al. Chronic sugar intake dampens feeding-related activity of neurons synthesizing a satiety mediator, oxytocin. Peptides. 2010;31(7):1346-52.
Mitra, A., Gosnell, B. A., Schiöth, H. B., Grace, M. K., Klockars, A., Olszewski, P. K., & Levine, A. S. (2010). Chronic sugar intake dampens feeding-related activity of neurons synthesizing a satiety mediator, oxytocin. Peptides, 31(7), pp. 1346-52. doi:10.1016/j.peptides.2010.04.005.
Mitra A, et al. Chronic Sugar Intake Dampens Feeding-related Activity of Neurons Synthesizing a Satiety Mediator, Oxytocin. Peptides. 2010;31(7):1346-52. PubMed PMID: 20399242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic sugar intake dampens feeding-related activity of neurons synthesizing a satiety mediator, oxytocin. AU - Mitra,Anaya, AU - Gosnell,Blake A, AU - Schiöth,Helgi B, AU - Grace,Martha K, AU - Klockars,Anica, AU - Olszewski,Pawel K, AU - Levine,Allen S, Y1 - 2010/04/22/ PY - 2010/02/01/received PY - 2010/04/06/revised PY - 2010/04/07/accepted PY - 2010/4/20/entrez PY - 2010/4/20/pubmed PY - 2010/9/15/medline SP - 1346 EP - 52 JF - Peptides JO - Peptides VL - 31 IS - 7 N2 - Increased tone of orexigens mediating reward occurs upon repeated consumption of sweet foods. Interestingly, some of these reward orexigens, such as opioids, diminish activity of neurons synthesizing oxytocin, a nonapeptide that promotes satiety and feeding termination. It is not known, however, whether consumption-related activity of the central oxytocin system is modified under chronic sugar feeding reward itself. Therefore, we examined how chronic consumption of a rewarding high-sucrose (HS) vs. bland cornstarch (CS) diet affected the activity of oxytocin cells in the hypothalamus at the time of meal termination. Schedule-fed (2h/day) rats received either a HS or CS powdered diet for 20 days. On the 21st day, they were given the same or the opposite diet, and food was removed after the main consummatory activity was completed. Animals were perfused 60 min after feeding termination and brains were immunostained for oxytocin and the marker of neuronal activity, c-Fos. The percentage of c-Fos-positive oxytocin cells in the hypothalamic paraventricular nucleus was significantly lower in rats chronically exposed to the HS than to the CS diet, regardless of which diet they received on the final day. A similar pattern was observed in the supraoptic nucleus. We conclude that the chronic rather than acute sucrose intake reduces activity of the anorexigenic oxytocin system. These findings indicate that chronic consumption of sugar blunts activity of pathways that mediate satiety. We speculate that a reduction in central satiety signaling precipitated by regular intake of foods high in sugar may lead to generalized overeating. SN - 1873-5169 UR - https://www.unboundmedicine.com/medline/citation/20399242/abstract/Chronic_sugar_intake_dampens_feeding_related_activity_of_neurons_synthesizing_a_satiety_mediator_oxytocin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0196-9781(10)00159-2 DB - PRIME DP - Unbound Medicine ER -