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Alterations of myelin proteins in inflammatory demyelination of BALB/c mice caused by Angiostrongylus cantonensis.
Vet Parasitol. 2010 Jul 15; 171(1-2):74-80.VP

Abstract

Angiostrongylus cantonensis causes eosinophilic meningitis or meningoencephalitis, yet little is known about demyelination caused by this parasite. To define the course of demyelination caused by A. cantonensis, we analyzed the expression of myelin proteins including myelin-associated glycoprotein (MAG), myelin basic protein (MBP), myelin-associated oligodendrocytic basic protein (MOBP), and proteolipid protein (PLP) in brain and cerebrospinal fluid (CSF)-like fluid of infected and uninfected BALB/c mice. In A. cantonensis-infected mice, the expression of MAG, MBP, MOBP, and PLP mRNAs in brain tissue was decreased, while expression of the corresponding proteins was significantly increased in CSF-like fluid. Light microscopy revealed perivascular infiltrates in the brain during meningoencephalitis, suggesting that the cause of demyelination in angiostrongyliasis was immune system attack on the oligodendrocytic myelin sheath and subsequent release of myelin proteins into the CSF. Thus, intracerebral myelin breakdown in angiostrongyliasis may be a response to inflammatory mediators and the cause of increased myelin proteins in the CSF-like fluid.

Authors+Show Affiliations

Institute of Medicine, Department of Parasitology, Chung Shan Medical University, and Clinical Laboratory, Chung Shan University Hospital, Taichung 402, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20399564

Citation

Lin, K Y., et al. "Alterations of Myelin Proteins in Inflammatory Demyelination of BALB/c Mice Caused By Angiostrongylus Cantonensis." Veterinary Parasitology, vol. 171, no. 1-2, 2010, pp. 74-80.
Lin KY, Chen KM, Lan KP, et al. Alterations of myelin proteins in inflammatory demyelination of BALB/c mice caused by Angiostrongylus cantonensis. Vet Parasitol. 2010;171(1-2):74-80.
Lin, K. Y., Chen, K. M., Lan, K. P., Lee, H. H., & Lai, S. C. (2010). Alterations of myelin proteins in inflammatory demyelination of BALB/c mice caused by Angiostrongylus cantonensis. Veterinary Parasitology, 171(1-2), 74-80. https://doi.org/10.1016/j.vetpar.2010.03.019
Lin KY, et al. Alterations of Myelin Proteins in Inflammatory Demyelination of BALB/c Mice Caused By Angiostrongylus Cantonensis. Vet Parasitol. 2010 Jul 15;171(1-2):74-80. PubMed PMID: 20399564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alterations of myelin proteins in inflammatory demyelination of BALB/c mice caused by Angiostrongylus cantonensis. AU - Lin,K Y, AU - Chen,K M, AU - Lan,K P, AU - Lee,H H, AU - Lai,S C, Y1 - 2010/03/30/ PY - 2009/11/17/received PY - 2010/03/08/revised PY - 2010/03/08/accepted PY - 2010/4/20/entrez PY - 2010/4/20/pubmed PY - 2010/10/1/medline SP - 74 EP - 80 JF - Veterinary parasitology JO - Vet Parasitol VL - 171 IS - 1-2 N2 - Angiostrongylus cantonensis causes eosinophilic meningitis or meningoencephalitis, yet little is known about demyelination caused by this parasite. To define the course of demyelination caused by A. cantonensis, we analyzed the expression of myelin proteins including myelin-associated glycoprotein (MAG), myelin basic protein (MBP), myelin-associated oligodendrocytic basic protein (MOBP), and proteolipid protein (PLP) in brain and cerebrospinal fluid (CSF)-like fluid of infected and uninfected BALB/c mice. In A. cantonensis-infected mice, the expression of MAG, MBP, MOBP, and PLP mRNAs in brain tissue was decreased, while expression of the corresponding proteins was significantly increased in CSF-like fluid. Light microscopy revealed perivascular infiltrates in the brain during meningoencephalitis, suggesting that the cause of demyelination in angiostrongyliasis was immune system attack on the oligodendrocytic myelin sheath and subsequent release of myelin proteins into the CSF. Thus, intracerebral myelin breakdown in angiostrongyliasis may be a response to inflammatory mediators and the cause of increased myelin proteins in the CSF-like fluid. SN - 1873-2550 UR - https://www.unboundmedicine.com/medline/citation/20399564/Alterations_of_myelin_proteins_in_inflammatory_demyelination_of_BALB/c_mice_caused_by_Angiostrongylus_cantonensis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-4017(10)00176-7 DB - PRIME DP - Unbound Medicine ER -