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Protective role of propolis against reproductive toxicity of triphenyltin in male rabbits.

Abstract

Triphenyltin (TPT) is known to cause endocrine disruption, reproductive toxicity and a decrease in testosterone production. It is involved in the production of reactive oxygen species. Propolis has been reported to be an important antioxidant. Therefore, the present study aimed to elucidate the possible protective effects of propolis in alleviating the toxicity of triphenyltin chloride (TPTCl) on reproductive performance, testosterone levels, lipid peroxidation and enzyme activities in seminal plasma of male New Zealand white rabbits. Animals were orally administered the doses of propolis, TPTCl and propolis plus TPTCl every day for 12weeks. Results showed that semen quality was deteriorated following treatment with TPTCl. Also, testosterone levels, body weight (BW), relative weights of testes (RWT) and epididymis (RWE) were decreased. Thiobarbituric acid-reactive substances and lactate dehydrogenase were increased, while glutathione S-transferase, transaminases and phosphatases were decreased in seminal plasma of rabbits treated with TPTCl compared to control. Propolis alone significantly increased testosterone levels, BW, RTW, REW, semen characteristics and seminal plasma enzymes, and decreased the levels of free radicals and lactate dehydrogenase. Furthermore, the presence of propolis with TPTCl alleviates its toxic effects. From the present study, it can be concluded propolis can be effective in the protection of TPTCl-induced reproductive toxicity.

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  • Authors+Show Affiliations

    ,

    Department of Home Economics, Faculty of Specific Education, Alexandria University, Alexandria, Egypt. yousefmokhtar@yahoo.com

    , ,

    Source

    MeSH

    Animals
    Antioxidants
    Body Weight
    Eating
    Epididymis
    Infertility, Male
    Male
    Organ Size
    Organotin Compounds
    Propolis
    Rabbits
    Reaction Time
    Semen
    Sperm Count
    Testicular Diseases
    Testis
    Testosterone

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20399825