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Estrogen receptor beta gene polymorphism and intraocular pressure elevation in female patients with primary open-angle glaucoma.
Am J Ophthalmol. 2010 May; 149(5):826-30.e1-2.AJ

Abstract

PURPOSE

To assess whether the genetic polymorphisms of estrogen receptor beta (ESR2) are associated with primary open-angle glaucoma (POAG).

DESIGN

Case-control study.

METHODS

Four hundred and twenty-five Japanese patients with POAG, including normal-tension glaucoma (NTG, n = 213) and high-tension glaucoma (HTG, n = 212), and 191 control subjects without glaucoma were analyzed for polymorphisms of rs1256031 and rs4986938 in the ESR2 gene. The genotypic and allelic frequencies were compared between NTG or HTG patients and control subjects. The phenotypic features of patients with POAG were compared between each genotype.

RESULTS

There were significant differences in the genotype frequencies of rs1256031 and rs4986938 between the HTG patients and control subjects in women (P = .033 and P = .043 respectively). The frequencies of the C allele of rs1256031 and G allele of rs4986938 were significantly higher in patients with HTG in comparison to the control subjects in women (rs1256031: 53.6% vs 43.4%, P = .044; rs4986938: 89.2% vs 80.6%, P = .027). The maximum intraocular pressures in female POAG patients with the CC or TC genotypes of rs1256031 were significantly higher than that in female POAG patients with the TT genotype (P = .039, analysis of variance, P = .018 and P = .026 respectively).

CONCLUSION

The ESR2 gene polymorphism is therefore considered to be associated with an intraocular pressure elevation in female patients with POAG.

Authors+Show Affiliations

Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan. fmabuchi@yamanashi.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20399928

Citation

Mabuchi, Fumihiko, et al. "Estrogen Receptor Beta Gene Polymorphism and Intraocular Pressure Elevation in Female Patients With Primary Open-angle Glaucoma." American Journal of Ophthalmology, vol. 149, no. 5, 2010, pp. 826-30.e1-2.
Mabuchi F, Sakurada Y, Kashiwagi K, et al. Estrogen receptor beta gene polymorphism and intraocular pressure elevation in female patients with primary open-angle glaucoma. Am J Ophthalmol. 2010;149(5):826-30.e1-2.
Mabuchi, F., Sakurada, Y., Kashiwagi, K., Yamagata, Z., Iijima, H., & Tsukahara, S. (2010). Estrogen receptor beta gene polymorphism and intraocular pressure elevation in female patients with primary open-angle glaucoma. American Journal of Ophthalmology, 149(5), 826-e1-2. https://doi.org/10.1016/j.ajo.2009.12.030
Mabuchi F, et al. Estrogen Receptor Beta Gene Polymorphism and Intraocular Pressure Elevation in Female Patients With Primary Open-angle Glaucoma. Am J Ophthalmol. 2010;149(5):826-30.e1-2. PubMed PMID: 20399928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estrogen receptor beta gene polymorphism and intraocular pressure elevation in female patients with primary open-angle glaucoma. AU - Mabuchi,Fumihiko, AU - Sakurada,Yoichi, AU - Kashiwagi,Kenji, AU - Yamagata,Zentaro, AU - Iijima,Hiroyuki, AU - Tsukahara,Shigeo, PY - 2009/09/04/received PY - 2009/12/16/revised PY - 2009/12/17/accepted PY - 2010/4/20/entrez PY - 2010/4/20/pubmed PY - 2010/5/7/medline SP - 826-30.e1-2 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 149 IS - 5 N2 - PURPOSE: To assess whether the genetic polymorphisms of estrogen receptor beta (ESR2) are associated with primary open-angle glaucoma (POAG). DESIGN: Case-control study. METHODS: Four hundred and twenty-five Japanese patients with POAG, including normal-tension glaucoma (NTG, n = 213) and high-tension glaucoma (HTG, n = 212), and 191 control subjects without glaucoma were analyzed for polymorphisms of rs1256031 and rs4986938 in the ESR2 gene. The genotypic and allelic frequencies were compared between NTG or HTG patients and control subjects. The phenotypic features of patients with POAG were compared between each genotype. RESULTS: There were significant differences in the genotype frequencies of rs1256031 and rs4986938 between the HTG patients and control subjects in women (P = .033 and P = .043 respectively). The frequencies of the C allele of rs1256031 and G allele of rs4986938 were significantly higher in patients with HTG in comparison to the control subjects in women (rs1256031: 53.6% vs 43.4%, P = .044; rs4986938: 89.2% vs 80.6%, P = .027). The maximum intraocular pressures in female POAG patients with the CC or TC genotypes of rs1256031 were significantly higher than that in female POAG patients with the TT genotype (P = .039, analysis of variance, P = .018 and P = .026 respectively). CONCLUSION: The ESR2 gene polymorphism is therefore considered to be associated with an intraocular pressure elevation in female patients with POAG. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/20399928/Estrogen_receptor_beta_gene_polymorphism_and_intraocular_pressure_elevation_in_female_patients_with_primary_open_angle_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(09)00971-4 DB - PRIME DP - Unbound Medicine ER -