Tags

Type your tag names separated by a space and hit enter

Impact of functional bowel symptoms on quality of life and fatigue in quiescent Crohn disease and irritable bowel syndrome.
Neurogastroenterol Motil. 2010 Jun; 22(6):626-e174.NM

Abstract

BACKGROUND

Patients with irritable bowel syndrome (IBS) and Crohn disease (CD) have impaired quality of life (Qol) associated with fatigue. Whether IBS-like symptoms have a similar impact on Qol and fatigue in quiescent CD than in IBS is currently unknown. Our aims were (i) to evaluate the prevalence of IBS-like symptoms in quiescent CD and (ii) to compare the impact of IBS-like symptoms on Qol and fatigue in both diseases.

METHODS

A total of 92 quiescent CD, 40 IBS and 20 healthy subjects similar in age were included prospectively in five French academic centers. IBS symptoms were evaluated through the Rome III criteria. The severity of IBS symptoms, Qol, fatigue, depression and anxiety was measured using questionnaires (Francis Score, Likert scales, Fatigue Impact Scale, short-form Beck and Hospital Anxiety and Depression Scale).

KEY RESULTS

Irritable bowel syndrome-like symptoms were found in 42/92 (45.6%) patients with quiescent CD. The presence of IBS-like symptoms was associated with significant more profound alterations of Qol, high scores of fatigue, depression, but similar levels of anxiety. Compared to CD patients with IBS-like symptoms, IBS patients had more severe gastrointestinal symptoms and alterations of Qol, but similar scores of fatigue, depression and anxiety. In quiescent CD patients, fatigue was independently associated with the presence of IBS-like symptoms (OR = 1.018, 95% CI: 1.002-1.034, P = 0.02).

CONCLUSIONS & INFERENCES

The prevalence of IBS-like symptoms is elevated in quiescent CD. The presence of IBS-like symptoms in quiescent CD is probably associated with the range of fatigue/depression disorders. The mechanism underlying the occurrence of IBS-like symptoms in quiescent CD needs to be further explored.

Authors+Show Affiliations

Faculté de Médecine, Université de Nice Sophia-Antipolis, CHU de Nice, Pôle Digestif, Nice, France. piche.t@chu-nice.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

20403099

Citation

Piche, T, et al. "Impact of Functional Bowel Symptoms On Quality of Life and Fatigue in Quiescent Crohn Disease and Irritable Bowel Syndrome." Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, vol. 22, no. 6, 2010, pp. 626-e174.
Piche T, Ducrotté P, Sabate JM, et al. Impact of functional bowel symptoms on quality of life and fatigue in quiescent Crohn disease and irritable bowel syndrome. Neurogastroenterol Motil. 2010;22(6):626-e174.
Piche, T., Ducrotté, P., Sabate, J. M., Coffin, B., Zerbib, F., Dapoigny, M., Hua, M., Marine-Barjoan, E., Dainese, R., & Hébuterne, X. (2010). Impact of functional bowel symptoms on quality of life and fatigue in quiescent Crohn disease and irritable bowel syndrome. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, 22(6), 626-e174. https://doi.org/10.1111/j.1365-2982.2010.01502.x
Piche T, et al. Impact of Functional Bowel Symptoms On Quality of Life and Fatigue in Quiescent Crohn Disease and Irritable Bowel Syndrome. Neurogastroenterol Motil. 2010;22(6):626-e174. PubMed PMID: 20403099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of functional bowel symptoms on quality of life and fatigue in quiescent Crohn disease and irritable bowel syndrome. AU - Piche,T, AU - Ducrotté,P, AU - Sabate,J M, AU - Coffin,B, AU - Zerbib,F, AU - Dapoigny,M, AU - Hua,M, AU - Marine-Barjoan,E, AU - Dainese,R, AU - Hébuterne,X, Y1 - 2010/04/19/ PY - 2010/4/21/entrez PY - 2010/4/21/pubmed PY - 2010/9/18/medline SP - 626 EP - e174 JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society JO - Neurogastroenterol Motil VL - 22 IS - 6 N2 - BACKGROUND: Patients with irritable bowel syndrome (IBS) and Crohn disease (CD) have impaired quality of life (Qol) associated with fatigue. Whether IBS-like symptoms have a similar impact on Qol and fatigue in quiescent CD than in IBS is currently unknown. Our aims were (i) to evaluate the prevalence of IBS-like symptoms in quiescent CD and (ii) to compare the impact of IBS-like symptoms on Qol and fatigue in both diseases. METHODS: A total of 92 quiescent CD, 40 IBS and 20 healthy subjects similar in age were included prospectively in five French academic centers. IBS symptoms were evaluated through the Rome III criteria. The severity of IBS symptoms, Qol, fatigue, depression and anxiety was measured using questionnaires (Francis Score, Likert scales, Fatigue Impact Scale, short-form Beck and Hospital Anxiety and Depression Scale). KEY RESULTS: Irritable bowel syndrome-like symptoms were found in 42/92 (45.6%) patients with quiescent CD. The presence of IBS-like symptoms was associated with significant more profound alterations of Qol, high scores of fatigue, depression, but similar levels of anxiety. Compared to CD patients with IBS-like symptoms, IBS patients had more severe gastrointestinal symptoms and alterations of Qol, but similar scores of fatigue, depression and anxiety. In quiescent CD patients, fatigue was independently associated with the presence of IBS-like symptoms (OR = 1.018, 95% CI: 1.002-1.034, P = 0.02). CONCLUSIONS & INFERENCES: The prevalence of IBS-like symptoms is elevated in quiescent CD. The presence of IBS-like symptoms in quiescent CD is probably associated with the range of fatigue/depression disorders. The mechanism underlying the occurrence of IBS-like symptoms in quiescent CD needs to be further explored. SN - 1365-2982 UR - https://www.unboundmedicine.com/medline/citation/20403099/Impact_of_functional_bowel_symptoms_on_quality_of_life_and_fatigue_in_quiescent_Crohn_disease_and_irritable_bowel_syndrome_ L2 - https://doi.org/10.1111/j.1365-2982.2010.01502.x DB - PRIME DP - Unbound Medicine ER -