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Role of the central amygdala GABA-A receptors in morphine state-dependent memory.
Life Sci. 2010 Jun 05; 86(23-24):887-93.LS

Abstract

AIMS

In the present experiments, the effects of bilateral microinjections of the GABA-A receptor agonist and/or antagonist into the central amygdala (CeA) on morphine state-dependent memory were examined.

MAIN METHODS

In order to assess memory retrieval, a step-through passive avoidance task was used in adult male Wistar rats.

KEY FINDINGS

Subcutaneous (s.c.) administration of morphine (5 and 7.5mg/kg) immediately after training (post-training) decreased the memory retrieval. Pre-test administration of the opioid (7.5mg/kg) also induced amnesia. The response induced by post-training morphine (7.5mg/kg) was significantly reversed by pre-test administration of the drug (5 and 7.5mg/kg), indicating morphine state-dependent memory. Pre-test intra-CeA microinjection of muscimol, a GABA-A receptor agonist (0.01, 0.02 and 0.03microg/rat) reduced morphine state-dependent memory. However, the same doses of muscimol by itself had no effect on memory retrieval. Furthermore, pre-test intra-CeA microinjection of bicuculline, a GABA-A receptor antagonist by itself did not alter memory retrieval. The antagonist also did not change post-training morphine (7.5mg/kg)-induced amnesia, but in combination with a lower dose of morphine (0.5mg/kg), improved memory performance. Moreover, muscimol's ability to interfere with morphine state-dependent memory was reversed by co-injection of bicuculline.

SIGNIFICANCE

The results suggest that GABA-A receptor mechanism of the CeA may influence morphine state-dependent memory.

Authors+Show Affiliations

Institute for Cognitive Science Studies, Tehran, Iran.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20403365

Citation

Rassouli, Yassaman, et al. "Role of the Central Amygdala GABA-A Receptors in Morphine State-dependent Memory." Life Sciences, vol. 86, no. 23-24, 2010, pp. 887-93.
Rassouli Y, Rezayof A, Zarrindast MR. Role of the central amygdala GABA-A receptors in morphine state-dependent memory. Life Sci. 2010;86(23-24):887-93.
Rassouli, Y., Rezayof, A., & Zarrindast, M. R. (2010). Role of the central amygdala GABA-A receptors in morphine state-dependent memory. Life Sciences, 86(23-24), 887-93. https://doi.org/10.1016/j.lfs.2010.04.006
Rassouli Y, Rezayof A, Zarrindast MR. Role of the Central Amygdala GABA-A Receptors in Morphine State-dependent Memory. Life Sci. 2010 Jun 5;86(23-24):887-93. PubMed PMID: 20403365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of the central amygdala GABA-A receptors in morphine state-dependent memory. AU - Rassouli,Yassaman, AU - Rezayof,Ameneh, AU - Zarrindast,Mohammad-Reza, Y1 - 2010/04/18/ PY - 2009/11/26/received PY - 2010/04/07/revised PY - 2010/04/12/accepted PY - 2010/4/21/entrez PY - 2010/4/21/pubmed PY - 2010/6/16/medline SP - 887 EP - 93 JF - Life sciences JO - Life Sci VL - 86 IS - 23-24 N2 - AIMS: In the present experiments, the effects of bilateral microinjections of the GABA-A receptor agonist and/or antagonist into the central amygdala (CeA) on morphine state-dependent memory were examined. MAIN METHODS: In order to assess memory retrieval, a step-through passive avoidance task was used in adult male Wistar rats. KEY FINDINGS: Subcutaneous (s.c.) administration of morphine (5 and 7.5mg/kg) immediately after training (post-training) decreased the memory retrieval. Pre-test administration of the opioid (7.5mg/kg) also induced amnesia. The response induced by post-training morphine (7.5mg/kg) was significantly reversed by pre-test administration of the drug (5 and 7.5mg/kg), indicating morphine state-dependent memory. Pre-test intra-CeA microinjection of muscimol, a GABA-A receptor agonist (0.01, 0.02 and 0.03microg/rat) reduced morphine state-dependent memory. However, the same doses of muscimol by itself had no effect on memory retrieval. Furthermore, pre-test intra-CeA microinjection of bicuculline, a GABA-A receptor antagonist by itself did not alter memory retrieval. The antagonist also did not change post-training morphine (7.5mg/kg)-induced amnesia, but in combination with a lower dose of morphine (0.5mg/kg), improved memory performance. Moreover, muscimol's ability to interfere with morphine state-dependent memory was reversed by co-injection of bicuculline. SIGNIFICANCE: The results suggest that GABA-A receptor mechanism of the CeA may influence morphine state-dependent memory. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/20403365/Role_of_the_central_amygdala_GABA_A_receptors_in_morphine_state_dependent_memory_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(10)00177-3 DB - PRIME DP - Unbound Medicine ER -