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Risk factors for venous thromboembolism: results from the Copenhagen City Heart Study.

Abstract

BACKGROUND

Studies have suggested a link between risk factors for atherosclerotic disease and venous thromboembolism (VTE), but results are heterogeneous. We sought to identify risk factors for VTE with a focus on risk factors for atherosclerotic disease.

METHODS AND RESULTS

Data were taken from the Copenhagen City Heart Study, a prospective cohort study of a random, age-stratified sample of people living in a defined area in Copenhagen, Denmark, started in 1976 with follow-up until 2007. First VTE (deep vein thrombosis and pulmonary embolism) diagnosis was retrieved from electronic national registries from study baseline to 2007. Of 18 954 subjects (median follow-up, 19.5 years) representing 360 399 person-years of follow-up, 969 subjects experienced at least 1 VTE, corresponding to a crude incidence rate of 2.69 (95% confidence interval [CI], 2.52 to 2.86) per 1000 person-years. The variables found to be significantly associated with VTE in a multivariable model adjusted for age and calendar time were as follows: body mass index (hazard ratio [HR] for >or=35 versus <20=2.10 [95% CI, 1.39 to 3.16]); smoking (HR for >or=25 g tobacco per day versus never smoker=1.52 [95% CI, 1.15 to 2.01]); gender (HR for men versus women=1.24 [95% CI, 1.08 to 1.42]); household income (HR for medium versus low=0.82 [95% CI, 0.70 to 0.95]); and diastolic blood pressure (HR for >100 versus <80 mm Hg=1.34 [95% CI, 1.08 to 1.66]). Other cardiovascular risk factors including total/high-density lipoprotein/low-density lipoprotein cholesterol levels, triglyceride levels, and diabetes mellitus were not associated with VTE.

CONCLUSIONS

Obesity and smoking were both found to be important risk factors for VTE whereas total/high-density lipoprotein/low-density lipoprotein cholesterol levels, triglyceride levels, and diabetes mellitus were not.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Danish Arrhythmia Research Center, Department of Cardiology B2142, University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark. anders@kanten.dk

    ,

    Source

    Circulation 121:17 2010 May 04 pg 1896-903

    MeSH

    Adult
    Age Distribution
    Aged
    Coronary Artery Disease
    Denmark
    Female
    Heavy Chain Disease
    Humans
    Hyperlipidemias
    Hypertension
    Immunoglobulin gamma-Chains
    Immunoglobulin mu-Chains
    Lipids
    Male
    Middle Aged
    Multivariate Analysis
    Obesity
    Prevalence
    Pulmonary Embolism
    Registries
    Risk Factors
    Sex Distribution
    Smoking
    Socioeconomic Factors
    Urban Population
    Venous Thromboembolism
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20404252

    Citation

    Holst, Anders G., et al. "Risk Factors for Venous Thromboembolism: Results From the Copenhagen City Heart Study." Circulation, vol. 121, no. 17, 2010, pp. 1896-903.
    Holst AG, Jensen G, Prescott E. Risk factors for venous thromboembolism: results from the Copenhagen City Heart Study. Circulation. 2010;121(17):1896-903.
    Holst, A. G., Jensen, G., & Prescott, E. (2010). Risk factors for venous thromboembolism: results from the Copenhagen City Heart Study. Circulation, 121(17), pp. 1896-903. doi:10.1161/CIRCULATIONAHA.109.921460.
    Holst AG, Jensen G, Prescott E. Risk Factors for Venous Thromboembolism: Results From the Copenhagen City Heart Study. Circulation. 2010 May 4;121(17):1896-903. PubMed PMID: 20404252.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Risk factors for venous thromboembolism: results from the Copenhagen City Heart Study. AU - Holst,Anders G, AU - Jensen,Gorm, AU - Prescott,Eva, Y1 - 2010/04/19/ PY - 2010/4/21/entrez PY - 2010/4/21/pubmed PY - 2010/5/25/medline SP - 1896 EP - 903 JF - Circulation JO - Circulation VL - 121 IS - 17 N2 - BACKGROUND: Studies have suggested a link between risk factors for atherosclerotic disease and venous thromboembolism (VTE), but results are heterogeneous. We sought to identify risk factors for VTE with a focus on risk factors for atherosclerotic disease. METHODS AND RESULTS: Data were taken from the Copenhagen City Heart Study, a prospective cohort study of a random, age-stratified sample of people living in a defined area in Copenhagen, Denmark, started in 1976 with follow-up until 2007. First VTE (deep vein thrombosis and pulmonary embolism) diagnosis was retrieved from electronic national registries from study baseline to 2007. Of 18 954 subjects (median follow-up, 19.5 years) representing 360 399 person-years of follow-up, 969 subjects experienced at least 1 VTE, corresponding to a crude incidence rate of 2.69 (95% confidence interval [CI], 2.52 to 2.86) per 1000 person-years. The variables found to be significantly associated with VTE in a multivariable model adjusted for age and calendar time were as follows: body mass index (hazard ratio [HR] for >or=35 versus <20=2.10 [95% CI, 1.39 to 3.16]); smoking (HR for >or=25 g tobacco per day versus never smoker=1.52 [95% CI, 1.15 to 2.01]); gender (HR for men versus women=1.24 [95% CI, 1.08 to 1.42]); household income (HR for medium versus low=0.82 [95% CI, 0.70 to 0.95]); and diastolic blood pressure (HR for >100 versus <80 mm Hg=1.34 [95% CI, 1.08 to 1.66]). Other cardiovascular risk factors including total/high-density lipoprotein/low-density lipoprotein cholesterol levels, triglyceride levels, and diabetes mellitus were not associated with VTE. CONCLUSIONS: Obesity and smoking were both found to be important risk factors for VTE whereas total/high-density lipoprotein/low-density lipoprotein cholesterol levels, triglyceride levels, and diabetes mellitus were not. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/20404252/Risk_factors_for_venous_thromboembolism:_results_from_the_Copenhagen_City_Heart_Study_ L2 - http://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.109.921460?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -