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Default-mode network dysfunction and cognitive impairment in progressive MS.
Neurology 2010; 74(16):1252-9Neur

Abstract

OBJECTIVE

This study explores default-mode network (DMN) abnormalities in patients with secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) and whether such abnormalities correlate with cognitive impairment and damage to selected white matter (WM) fiber bundles, quantified using diffusion tensor (DT) MRI tractography.

METHODS

Resting state (RS) functional MRI and DT MRI data were acquired from 33 patients with SPMS, 24 patients with PPMS, and 24 controls. Independent component analysis (ICA) was used to identify the DMN. SPM5 was used to assess within- and between-group activations.

RESULTS

Between-group differences in DMN activity were found in the left medial prefrontal cortex (mPFC), left precentral gyrus (PcG), and anterior cingulate cortex (ACC). Compared to controls, patients with SPMS had reduced activity in the mPFC (p = 0.01) and PcG (p = 0.02), while patients with PPMS had reduced activity in the PcG (p = 0.008) and the ACC (p = 0.002). Compared to patients with PPMS, patients with SPMS had increased ACC activity (p = 0.04). Reduction of RS activity in the ACC was more pronounced in cognitively impaired vs cognitively preserved patients with MS (p = 0.02). In patients with MS, DMN abnormalities correlated with the PASAT and word list test scores (r values ranging from 0.35 to 0.45) and DT MRI changes in the corpus callosum and the cingulum (r values ranging from 0.82 to 0.87).

CONCLUSION

These results suggest that a dysfunction of the anterior components of the default-mode network may be among the factors responsible for the accumulation of cognitive deficits in patients with progressive multiple sclerosis.

Authors+Show Affiliations

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20404306

Citation

Rocca, M A., et al. "Default-mode Network Dysfunction and Cognitive Impairment in Progressive MS." Neurology, vol. 74, no. 16, 2010, pp. 1252-9.
Rocca MA, Valsasina P, Absinta M, et al. Default-mode network dysfunction and cognitive impairment in progressive MS. Neurology. 2010;74(16):1252-9.
Rocca, M. A., Valsasina, P., Absinta, M., Riccitelli, G., Rodegher, M. E., Misci, P., ... Filippi, M. (2010). Default-mode network dysfunction and cognitive impairment in progressive MS. Neurology, 74(16), pp. 1252-9. doi:10.1212/WNL.0b013e3181d9ed91.
Rocca MA, et al. Default-mode Network Dysfunction and Cognitive Impairment in Progressive MS. Neurology. 2010 Apr 20;74(16):1252-9. PubMed PMID: 20404306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Default-mode network dysfunction and cognitive impairment in progressive MS. AU - Rocca,M A, AU - Valsasina,P, AU - Absinta,M, AU - Riccitelli,G, AU - Rodegher,M E, AU - Misci,P, AU - Rossi,P, AU - Falini,A, AU - Comi,G, AU - Filippi,M, PY - 2010/4/21/entrez PY - 2010/4/21/pubmed PY - 2010/6/9/medline SP - 1252 EP - 9 JF - Neurology JO - Neurology VL - 74 IS - 16 N2 - OBJECTIVE: This study explores default-mode network (DMN) abnormalities in patients with secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) and whether such abnormalities correlate with cognitive impairment and damage to selected white matter (WM) fiber bundles, quantified using diffusion tensor (DT) MRI tractography. METHODS: Resting state (RS) functional MRI and DT MRI data were acquired from 33 patients with SPMS, 24 patients with PPMS, and 24 controls. Independent component analysis (ICA) was used to identify the DMN. SPM5 was used to assess within- and between-group activations. RESULTS: Between-group differences in DMN activity were found in the left medial prefrontal cortex (mPFC), left precentral gyrus (PcG), and anterior cingulate cortex (ACC). Compared to controls, patients with SPMS had reduced activity in the mPFC (p = 0.01) and PcG (p = 0.02), while patients with PPMS had reduced activity in the PcG (p = 0.008) and the ACC (p = 0.002). Compared to patients with PPMS, patients with SPMS had increased ACC activity (p = 0.04). Reduction of RS activity in the ACC was more pronounced in cognitively impaired vs cognitively preserved patients with MS (p = 0.02). In patients with MS, DMN abnormalities correlated with the PASAT and word list test scores (r values ranging from 0.35 to 0.45) and DT MRI changes in the corpus callosum and the cingulum (r values ranging from 0.82 to 0.87). CONCLUSION: These results suggest that a dysfunction of the anterior components of the default-mode network may be among the factors responsible for the accumulation of cognitive deficits in patients with progressive multiple sclerosis. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/20404306/Default_mode_network_dysfunction_and_cognitive_impairment_in_progressive_MS_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=20404306 DB - PRIME DP - Unbound Medicine ER -