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Specific antibodies to cow's milk proteins in infants: effect of early feeding and diagnosis of cow's milk allergy.
Eur J Nutr. 2010 Dec; 49(8):501-4.EJ

Abstract

PURPOSE

To investigate whether specific IgA, IgG, IgG1 and IgG4 responses to cow's milk proteins differ between infants with cow's milk allergy and infants with cow's milk related symptoms (control subjects), and whether early feeding affects these responses as well as specific IgE.

METHODS

A cohort of 6,209 healthy, full-term infants in a double-blind randomized trial received, as supplementary feeding at maternity hospitals (mean duration 4 days), either cow's milk formula, extensively hydrolyzed whey formula or donor breast milk. Infants who developed cow's milk associated symptoms (n = 223) underwent an open oral cow's milk challenge (mean age 7 months), which confirmed cow's milk allergy in 111 and was negative in 112. We measured in sera cow's milk specific IgE levels with UniCAP (Phadia, Uppsala, Sweden), and β-lactoglobulin and α-casein specific IgA, IgG1, IgG4 and IgG levels with enzyme-linked immunosorbent assay.

RESULTS

Infants with IgE-mediated cow's milk allergy had lower β-lactoglobulin and α-casein specific IgG1, IgG4 and IgG levels (p < 0.05) than infants with non-IgE-mediated cow's milk allergy or control subjects. Within the group of infants with cow's milk allergy, exposure to cow's milk during the first few days after birth led to higher β-lactoglobulin and α-casein specific IgG4 levels (p < 0.005) compared to infants fed with either breast milk or extensively hydrolyzed formula.

CONCLUSIONS

Subdued IgG class responses to cow's milk proteins characterized IgE-mediated cow's milk allergy. In infants who developed cow's milk allergy early exposure to cow's milk resulted in a heightened specific IgG4 response.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Savilahti EM
Hospital for Children and Adolescents, University of Helsinki, PO Box 281, 00029 Helsinki, Finland.
Saarinen KM
No affiliation info available
Savilahti E
No affiliation info available

MeSH

AnimalsCohort StudiesDouble-Blind MethodEarly DiagnosisHumansImmunoglobulin AImmunoglobulin EImmunoglobulin GImmunoglobulin IsotypesInfantInfant FormulaInfant, NewbornMilkMilk HypersensitivityMilk ProteinsSweden

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20405136

Citation

Savilahti, Emma Merike, et al. "Specific Antibodies to Cow's Milk Proteins in Infants: Effect of Early Feeding and Diagnosis of Cow's Milk Allergy." European Journal of Nutrition, vol. 49, no. 8, 2010, pp. 501-4.
Savilahti EM, Saarinen KM, Savilahti E. Specific antibodies to cow's milk proteins in infants: effect of early feeding and diagnosis of cow's milk allergy. Eur J Nutr. 2010;49(8):501-4.
Savilahti, E. M., Saarinen, K. M., & Savilahti, E. (2010). Specific antibodies to cow's milk proteins in infants: effect of early feeding and diagnosis of cow's milk allergy. European Journal of Nutrition, 49(8), 501-4. https://doi.org/10.1007/s00394-010-0109-8
Savilahti EM, Saarinen KM, Savilahti E. Specific Antibodies to Cow's Milk Proteins in Infants: Effect of Early Feeding and Diagnosis of Cow's Milk Allergy. Eur J Nutr. 2010;49(8):501-4. PubMed PMID: 20405136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Specific antibodies to cow's milk proteins in infants: effect of early feeding and diagnosis of cow's milk allergy. AU - Savilahti,Emma Merike, AU - Saarinen,Kristiina Mertta, AU - Savilahti,Erkki, Y1 - 2010/04/20/ PY - 2010/01/27/received PY - 2010/04/06/accepted PY - 2010/4/21/entrez PY - 2010/4/21/pubmed PY - 2011/3/2/medline SP - 501 EP - 4 JF - European journal of nutrition JO - Eur J Nutr VL - 49 IS - 8 N2 - PURPOSE: To investigate whether specific IgA, IgG, IgG1 and IgG4 responses to cow's milk proteins differ between infants with cow's milk allergy and infants with cow's milk related symptoms (control subjects), and whether early feeding affects these responses as well as specific IgE. METHODS: A cohort of 6,209 healthy, full-term infants in a double-blind randomized trial received, as supplementary feeding at maternity hospitals (mean duration 4 days), either cow's milk formula, extensively hydrolyzed whey formula or donor breast milk. Infants who developed cow's milk associated symptoms (n = 223) underwent an open oral cow's milk challenge (mean age 7 months), which confirmed cow's milk allergy in 111 and was negative in 112. We measured in sera cow's milk specific IgE levels with UniCAP (Phadia, Uppsala, Sweden), and β-lactoglobulin and α-casein specific IgA, IgG1, IgG4 and IgG levels with enzyme-linked immunosorbent assay. RESULTS: Infants with IgE-mediated cow's milk allergy had lower β-lactoglobulin and α-casein specific IgG1, IgG4 and IgG levels (p < 0.05) than infants with non-IgE-mediated cow's milk allergy or control subjects. Within the group of infants with cow's milk allergy, exposure to cow's milk during the first few days after birth led to higher β-lactoglobulin and α-casein specific IgG4 levels (p < 0.005) compared to infants fed with either breast milk or extensively hydrolyzed formula. CONCLUSIONS: Subdued IgG class responses to cow's milk proteins characterized IgE-mediated cow's milk allergy. In infants who developed cow's milk allergy early exposure to cow's milk resulted in a heightened specific IgG4 response. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/20405136/Specific_antibodies_to_cow's_milk_proteins_in_infants:_effect_of_early_feeding_and_diagnosis_of_cow's_milk_allergy_ L2 - https://dx.doi.org/10.1007/s00394-010-0109-8 DB - PRIME DP - Unbound Medicine ER -