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[Immune polymorphism analysis of HLA class II antigens in ulcer diseases associated with Helicobacter pylori in children].

Abstract

Previous investigations have linked specific HLA class II alleles DRB1 and DQB1 to H. pylori infection (Y. Huang et al., 2005).

AIM

to investigate potential contribution of HLA-DRB1 and DQB1 alleles in H. pylori infection susceptibility in a Russian pediatric population.

METHODS

Polymerase chain reaction-sequence specific primer (PCR-SSP) method was used to study the HLA-DRB1, DQB1 allelic frequency distribution in 162 children (93 female) with H. pylori infection was determined by culture, breath test and histology.

RESULTS

The carrier frequency of DQB1*03 was higher among H. pylori--positive patients with chronic gastritis only compared with H. pylori-negative patients. The difference in carrier frequencies for HLA-DRB1*17 was higher in H. pylori-positive ulcer patients compared with an uninfected controls (chi2 = 3.69, p = 0.027). In addition, the frequency of genotypes that possess HLA-DQB1*07 allele in the H. pylori-positive children (with peptic ulcer/ chronic gastritis only) was significantly lower than that in the H. pylori-negative control group.

CONCLUSIONS

HLA-DQB1*07 allele may be associated with protection against H. pylori infection independently of clinical outcome. At the same time, HLA-DRB1*17 allele might be associated with susceptible gene to peptic ulcer formation among H. pylori-positive children.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

rus

PubMed ID

20405713

Citation

Nizhevich, A A., et al. "[Immune Polymorphism Analysis of HLA Class II Antigens in Ulcer Diseases Associated With Helicobacter Pylori in Children]." Eksperimental'naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology, 2010, pp. 58-63.
Nizhevich AA, Shcherbakov PL, Akhmadeeva EN, et al. [Immune polymorphism analysis of HLA class II antigens in ulcer diseases associated with Helicobacter pylori in children]. Eksp Klin Gastroenterol. 2010.
Nizhevich, A. A., Shcherbakov, P. L., Akhmadeeva, E. N., Sataev, V. U., Elicheva, Z. M., Usmanova, I. Z., & Tsyglintseva, N. P. (2010). [Immune polymorphism analysis of HLA class II antigens in ulcer diseases associated with Helicobacter pylori in children]. Eksperimental'naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology, (1), 58-63.
Nizhevich AA, et al. [Immune Polymorphism Analysis of HLA Class II Antigens in Ulcer Diseases Associated With Helicobacter Pylori in Children]. Eksp Klin Gastroenterol. 2010;(1)58-63. PubMed PMID: 20405713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Immune polymorphism analysis of HLA class II antigens in ulcer diseases associated with Helicobacter pylori in children]. AU - Nizhevich,A A, AU - Shcherbakov,P L, AU - Akhmadeeva,E N, AU - Sataev,V U, AU - Elicheva,Z M, AU - Usmanova,I Z, AU - Tsyglintseva,N P, PY - 2010/4/22/entrez PY - 2010/4/22/pubmed PY - 2010/7/27/medline SP - 58 EP - 63 JF - Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology JO - Eksp Klin Gastroenterol IS - 1 N2 - UNLABELLED: Previous investigations have linked specific HLA class II alleles DRB1 and DQB1 to H. pylori infection (Y. Huang et al., 2005). AIM: to investigate potential contribution of HLA-DRB1 and DQB1 alleles in H. pylori infection susceptibility in a Russian pediatric population. METHODS: Polymerase chain reaction-sequence specific primer (PCR-SSP) method was used to study the HLA-DRB1, DQB1 allelic frequency distribution in 162 children (93 female) with H. pylori infection was determined by culture, breath test and histology. RESULTS: The carrier frequency of DQB1*03 was higher among H. pylori--positive patients with chronic gastritis only compared with H. pylori-negative patients. The difference in carrier frequencies for HLA-DRB1*17 was higher in H. pylori-positive ulcer patients compared with an uninfected controls (chi2 = 3.69, p = 0.027). In addition, the frequency of genotypes that possess HLA-DQB1*07 allele in the H. pylori-positive children (with peptic ulcer/ chronic gastritis only) was significantly lower than that in the H. pylori-negative control group. CONCLUSIONS: HLA-DQB1*07 allele may be associated with protection against H. pylori infection independently of clinical outcome. At the same time, HLA-DRB1*17 allele might be associated with susceptible gene to peptic ulcer formation among H. pylori-positive children. SN - 1682-8658 UR - https://www.unboundmedicine.com/medline/citation/20405713/[Immune_polymorphism_analysis_of_HLA_class_II_antigens_in_ulcer_diseases_associated_with_Helicobacter_pylori_in_children]_ L2 - https://medlineplus.gov/pepticulcer.html DB - PRIME DP - Unbound Medicine ER -