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Detection of Delta9-tetrahydrocannabinol and amphetamine-type stimulants in oral fluid using the Rapid Stat point-of-collection drug-testing device.
J Anal Toxicol. 2010 Apr; 34(3):155-61.JA

Abstract

The Rapid Stat assay, a point-of-collection drug-testing device for detection of amphetamines, cannabinoids, cocaine, opiates, methadone, and benzodiazepines in oral fluid, was evaluated for cannabis and amphetamine-type stimulants. The Rapid Stat tests (n = 134) were applied by police officers in routine traffic checks. Oral fluid and blood samples were analyzed using gas chromatography-mass spectrometry (GC-MS) for Delta(9)-tetrahydrocannabinol, amphetamine, methamphetamine, methylenedioxymethamphetamine, methylenedioxyethylamphetamine, and methylenedioxyamphetamine. The comparison of GC-MS analysis of oral fluid with the Rapid Stat results for cannabis showed a sensitivity of 85%, a specificity of 87%, and a total confirmation rate of 87%. When compared with serum, the sensitivity of the cannabis assay decreased to 71%, the specificity to 60%, and the total confirmation rate to 66%. These findings were possibly caused by an incorrect reading of the THC test results. Comparison of the Rapid Stat amphetamine assay with GC-MS in oral fluid showed a sensitivity of 94%, a specificity of 97%, and a total confirmation rate of 97%. Compared with serum, a sensitivity of 100%, a specificity of 90%, and a total confirmation rate of 92% was found. The amphetamine assay must, therefore, be regarded as satisfactory.

Authors+Show Affiliations

Institute of Legal Medicine, Johannes Gutenberg-University Mainz, Am Pulverturm 3, Mainz, Germany. roehrich@uni-mainz.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20406540

Citation

Röhrich, J, et al. "Detection of Delta9-tetrahydrocannabinol and Amphetamine-type Stimulants in Oral Fluid Using the Rapid Stat Point-of-collection Drug-testing Device." Journal of Analytical Toxicology, vol. 34, no. 3, 2010, pp. 155-61.
Röhrich J, Zörntlein S, Becker J, et al. Detection of Delta9-tetrahydrocannabinol and amphetamine-type stimulants in oral fluid using the Rapid Stat point-of-collection drug-testing device. J Anal Toxicol. 2010;34(3):155-61.
Röhrich, J., Zörntlein, S., Becker, J., & Urban, R. (2010). Detection of Delta9-tetrahydrocannabinol and amphetamine-type stimulants in oral fluid using the Rapid Stat point-of-collection drug-testing device. Journal of Analytical Toxicology, 34(3), 155-61.
Röhrich J, et al. Detection of Delta9-tetrahydrocannabinol and Amphetamine-type Stimulants in Oral Fluid Using the Rapid Stat Point-of-collection Drug-testing Device. J Anal Toxicol. 2010;34(3):155-61. PubMed PMID: 20406540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of Delta9-tetrahydrocannabinol and amphetamine-type stimulants in oral fluid using the Rapid Stat point-of-collection drug-testing device. AU - Röhrich,J, AU - Zörntlein,S, AU - Becker,J, AU - Urban,R, PY - 2010/4/22/entrez PY - 2010/4/22/pubmed PY - 2010/9/29/medline SP - 155 EP - 61 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 34 IS - 3 N2 - The Rapid Stat assay, a point-of-collection drug-testing device for detection of amphetamines, cannabinoids, cocaine, opiates, methadone, and benzodiazepines in oral fluid, was evaluated for cannabis and amphetamine-type stimulants. The Rapid Stat tests (n = 134) were applied by police officers in routine traffic checks. Oral fluid and blood samples were analyzed using gas chromatography-mass spectrometry (GC-MS) for Delta(9)-tetrahydrocannabinol, amphetamine, methamphetamine, methylenedioxymethamphetamine, methylenedioxyethylamphetamine, and methylenedioxyamphetamine. The comparison of GC-MS analysis of oral fluid with the Rapid Stat results for cannabis showed a sensitivity of 85%, a specificity of 87%, and a total confirmation rate of 87%. When compared with serum, the sensitivity of the cannabis assay decreased to 71%, the specificity to 60%, and the total confirmation rate to 66%. These findings were possibly caused by an incorrect reading of the THC test results. Comparison of the Rapid Stat amphetamine assay with GC-MS in oral fluid showed a sensitivity of 94%, a specificity of 97%, and a total confirmation rate of 97%. Compared with serum, a sensitivity of 100%, a specificity of 90%, and a total confirmation rate of 92% was found. The amphetamine assay must, therefore, be regarded as satisfactory. SN - 1945-2403 UR - https://www.unboundmedicine.com/medline/citation/20406540/Detection_of_Delta9_tetrahydrocannabinol_and_amphetamine_type_stimulants_in_oral_fluid_using_the_Rapid_Stat_point_of_collection_drug_testing_device_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/34.3.155 DB - PRIME DP - Unbound Medicine ER -