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Upper control limit of reactive oxygen species in follicular fluid beyond which viable embryo formation is not favorable.
Reprod Toxicol 2010; 29(4):447-51RT

Abstract

Though the role of reactive oxygen species (ROS) in female infertility has been a subject of rigorous research worldwide, there is inadequate information on the cut-off value of ROS in the oocyte microenvironment beyond which ART outcome may be adversely affected. An upper ROS level in follicular fluid (FF) samples of women undergoing IVF beyond which good quality embryo formation is unlikely, is established. ROS, lipid peroxidation and total antioxidant capacity were estimated. The upper cut-off ROS level beyond which viable embryo formation is not favorable was found to be approximately 107 cps/400 microl FF. This level, determined in women with tubal factor infertility, was further validated in women with endometriosis and PCOS and correlated with fertilization and pregnancy rate and embryo quality. Summarizing, a threshold level in FF has been established for the first time beyond which ROS may be considered toxic for viable embryo formation and pregnancy outcome.

Authors+Show Affiliations

School of Medical Science and Technology, Indian Institute of Technology, Kharagpur 721302, W.B., India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20406678

Citation

Jana, Saikat K., et al. "Upper Control Limit of Reactive Oxygen Species in Follicular Fluid Beyond Which Viable Embryo Formation Is Not Favorable." Reproductive Toxicology (Elmsford, N.Y.), vol. 29, no. 4, 2010, pp. 447-51.
Jana SK, K NB, Chattopadhyay R, et al. Upper control limit of reactive oxygen species in follicular fluid beyond which viable embryo formation is not favorable. Reprod Toxicol. 2010;29(4):447-51.
Jana, S. K., K, N. B., Chattopadhyay, R., Chakravarty, B., & Chaudhury, K. (2010). Upper control limit of reactive oxygen species in follicular fluid beyond which viable embryo formation is not favorable. Reproductive Toxicology (Elmsford, N.Y.), 29(4), pp. 447-51. doi:10.1016/j.reprotox.2010.04.002.
Jana SK, et al. Upper Control Limit of Reactive Oxygen Species in Follicular Fluid Beyond Which Viable Embryo Formation Is Not Favorable. Reprod Toxicol. 2010;29(4):447-51. PubMed PMID: 20406678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Upper control limit of reactive oxygen species in follicular fluid beyond which viable embryo formation is not favorable. AU - Jana,Saikat K, AU - K,Narendra Babu, AU - Chattopadhyay,Ratna, AU - Chakravarty,Baidyanath, AU - Chaudhury,Koel, Y1 - 2010/04/18/ PY - 2009/10/23/received PY - 2010/03/19/revised PY - 2010/04/09/accepted PY - 2010/4/22/entrez PY - 2010/4/22/pubmed PY - 2010/9/23/medline SP - 447 EP - 51 JF - Reproductive toxicology (Elmsford, N.Y.) JO - Reprod. Toxicol. VL - 29 IS - 4 N2 - Though the role of reactive oxygen species (ROS) in female infertility has been a subject of rigorous research worldwide, there is inadequate information on the cut-off value of ROS in the oocyte microenvironment beyond which ART outcome may be adversely affected. An upper ROS level in follicular fluid (FF) samples of women undergoing IVF beyond which good quality embryo formation is unlikely, is established. ROS, lipid peroxidation and total antioxidant capacity were estimated. The upper cut-off ROS level beyond which viable embryo formation is not favorable was found to be approximately 107 cps/400 microl FF. This level, determined in women with tubal factor infertility, was further validated in women with endometriosis and PCOS and correlated with fertilization and pregnancy rate and embryo quality. Summarizing, a threshold level in FF has been established for the first time beyond which ROS may be considered toxic for viable embryo formation and pregnancy outcome. SN - 1873-1708 UR - https://www.unboundmedicine.com/medline/citation/20406678/Upper_control_limit_of_reactive_oxygen_species_in_follicular_fluid_beyond_which_viable_embryo_formation_is_not_favorable_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-6238(10)00080-8 DB - PRIME DP - Unbound Medicine ER -