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Dietary fiber and colorectal cancer risk: a nested case-control study using food diaries.
J Natl Cancer Inst 2010; 102(9):614-26JNCI

Abstract

BACKGROUND

Results of epidemiological studies of dietary fiber and colorectal cancer risk have not been consistent, possibly because of attenuation of associations due to measurement error in dietary exposure ascertainment.

METHODS

To examine the association between dietary fiber intake and colorectal cancer risk, we conducted a prospective case-control study nested within seven UK cohort studies, which included 579 case patients who developed incident colorectal cancer and 1996 matched control subjects. We used standardized dietary data obtained from 4- to 7-day food diaries that were completed by all participants to calculate the odds ratios for colorectal, colon, and rectal cancers with the use of conditional logistic regression models that adjusted for relevant covariates. We also calculated odds ratios for colorectal cancer by using dietary data obtained from food-frequency questionnaires that were completed by most participants. All statistical tests were two-sided.

RESULTS

Intakes of absolute fiber and of fiber intake density, ascertained by food diaries, were statistically significantly inversely associated with the risks of colorectal and colon cancers in both age-adjusted models and multivariable models that adjusted for age; anthropomorphic and socioeconomic factors; and dietary intakes of folate, alcohol, and energy. For example, the multivariable-adjusted odds ratio of colorectal cancer for highest vs the lowest quintile of fiber intake density was 0.66 (95% confidence interval = 0.45 to 0.96). However, no statistically significant association was observed when the same analysis was conducted using dietary data obtained by food-frequency questionnaire (multivariable odds ratio = 0.88, 95% confidence interval = 0.57 to 1.36).

CONCLUSIONS

Intake of dietary fiber is inversely associated with colorectal cancer risk. Methodological differences (ie, study design, dietary assessment instruments, definition of fiber) may account for the lack of convincing evidence for the inverse association between fiber intake and colorectal cancer risk in some previous studies.

Authors+Show Affiliations

Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20407088

Citation

Dahm, Christina C., et al. "Dietary Fiber and Colorectal Cancer Risk: a Nested Case-control Study Using Food Diaries." Journal of the National Cancer Institute, vol. 102, no. 9, 2010, pp. 614-26.
Dahm CC, Keogh RH, Spencer EA, et al. Dietary fiber and colorectal cancer risk: a nested case-control study using food diaries. J Natl Cancer Inst. 2010;102(9):614-26.
Dahm, C. C., Keogh, R. H., Spencer, E. A., Greenwood, D. C., Key, T. J., Fentiman, I. S., ... Rodwell Bingham, S. A. (2010). Dietary fiber and colorectal cancer risk: a nested case-control study using food diaries. Journal of the National Cancer Institute, 102(9), pp. 614-26. doi:10.1093/jnci/djq092.
Dahm CC, et al. Dietary Fiber and Colorectal Cancer Risk: a Nested Case-control Study Using Food Diaries. J Natl Cancer Inst. 2010 May 5;102(9):614-26. PubMed PMID: 20407088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fiber and colorectal cancer risk: a nested case-control study using food diaries. AU - Dahm,Christina C, AU - Keogh,Ruth H, AU - Spencer,Elizabeth A, AU - Greenwood,Darren C, AU - Key,Tim J, AU - Fentiman,Ian S, AU - Shipley,Martin J, AU - Brunner,Eric J, AU - Cade,Janet E, AU - Burley,Victoria J, AU - Mishra,Gita, AU - Stephen,Alison M, AU - Kuh,Diana, AU - White,Ian R, AU - Luben,Robert, AU - Lentjes,Marleen A H, AU - Khaw,Kay Tee, AU - Rodwell Bingham,Sheila A, Y1 - 2010/04/20/ PY - 2010/4/22/entrez PY - 2010/4/22/pubmed PY - 2010/5/13/medline SP - 614 EP - 26 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 102 IS - 9 N2 - BACKGROUND: Results of epidemiological studies of dietary fiber and colorectal cancer risk have not been consistent, possibly because of attenuation of associations due to measurement error in dietary exposure ascertainment. METHODS: To examine the association between dietary fiber intake and colorectal cancer risk, we conducted a prospective case-control study nested within seven UK cohort studies, which included 579 case patients who developed incident colorectal cancer and 1996 matched control subjects. We used standardized dietary data obtained from 4- to 7-day food diaries that were completed by all participants to calculate the odds ratios for colorectal, colon, and rectal cancers with the use of conditional logistic regression models that adjusted for relevant covariates. We also calculated odds ratios for colorectal cancer by using dietary data obtained from food-frequency questionnaires that were completed by most participants. All statistical tests were two-sided. RESULTS: Intakes of absolute fiber and of fiber intake density, ascertained by food diaries, were statistically significantly inversely associated with the risks of colorectal and colon cancers in both age-adjusted models and multivariable models that adjusted for age; anthropomorphic and socioeconomic factors; and dietary intakes of folate, alcohol, and energy. For example, the multivariable-adjusted odds ratio of colorectal cancer for highest vs the lowest quintile of fiber intake density was 0.66 (95% confidence interval = 0.45 to 0.96). However, no statistically significant association was observed when the same analysis was conducted using dietary data obtained by food-frequency questionnaire (multivariable odds ratio = 0.88, 95% confidence interval = 0.57 to 1.36). CONCLUSIONS: Intake of dietary fiber is inversely associated with colorectal cancer risk. Methodological differences (ie, study design, dietary assessment instruments, definition of fiber) may account for the lack of convincing evidence for the inverse association between fiber intake and colorectal cancer risk in some previous studies. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/20407088/Dietary_fiber_and_colorectal_cancer_risk:_a_nested_case_control_study_using_food_diaries_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djq092 DB - PRIME DP - Unbound Medicine ER -