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Lyme borreliosis: current issues in diagnosis and management.
Curr Opin Infect Dis. 2010 Jun; 23(3):231-5.CO

Abstract

PURPOSE OF REVIEW

Lyme borreliosis is the most common vector-borne bacterial infection in temperate areas of the northern hemisphere. It has been perceived as difficult to diagnose and treat, but much is now known about its clinical presentations, which largely fall into well defined categories in both adults and children. This review features recent publications on clinical diagnosis and management.

RECENT FINDINGS

The reported incidence of Lyme borreliosis has increased markedly in many countries. Many recent publications have focused on clinical and laboratory aspects of paediatric and adult neuroborreliosis, and there is now strong evidence for the efficacy of oral doxycycline for most presentations of neuroborreliosis. Serological tests have improved significantly. Several studies have confirmed that patients treated for early Lyme borreliosis have good overall long-term outcomes. Studies of patients with persistent symptoms following treatment have not shown evidence for active infection or for sustained benefit from prolonged antibiotic treatment.

SUMMARY

Greater efforts are needed to provide education for prevention and early diagnosis to avoid late complications. Further improvements in diagnostic tests would be welcomed. More research is required to assess the causes and management of post-Lyme symptoms.

Authors+Show Affiliations

Lyme Borreliosis Unit, Health Protection Agency Microbiology Laboratory, Southampton University Hospitals Trust, Southampton, UK. Susan.OConnell@suht.swest.nhs.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20407371

Citation

O'Connell, Sue. "Lyme Borreliosis: Current Issues in Diagnosis and Management." Current Opinion in Infectious Diseases, vol. 23, no. 3, 2010, pp. 231-5.
O'Connell S. Lyme borreliosis: current issues in diagnosis and management. Curr Opin Infect Dis. 2010;23(3):231-5.
O'Connell, S. (2010). Lyme borreliosis: current issues in diagnosis and management. Current Opinion in Infectious Diseases, 23(3), 231-5. https://doi.org/10.1097/QCO.0b013e32833890e2
O'Connell S. Lyme Borreliosis: Current Issues in Diagnosis and Management. Curr Opin Infect Dis. 2010;23(3):231-5. PubMed PMID: 20407371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lyme borreliosis: current issues in diagnosis and management. A1 - O'Connell,Sue, PY - 2010/4/22/entrez PY - 2010/4/22/pubmed PY - 2010/7/14/medline SP - 231 EP - 5 JF - Current opinion in infectious diseases JO - Curr. Opin. Infect. Dis. VL - 23 IS - 3 N2 - PURPOSE OF REVIEW: Lyme borreliosis is the most common vector-borne bacterial infection in temperate areas of the northern hemisphere. It has been perceived as difficult to diagnose and treat, but much is now known about its clinical presentations, which largely fall into well defined categories in both adults and children. This review features recent publications on clinical diagnosis and management. RECENT FINDINGS: The reported incidence of Lyme borreliosis has increased markedly in many countries. Many recent publications have focused on clinical and laboratory aspects of paediatric and adult neuroborreliosis, and there is now strong evidence for the efficacy of oral doxycycline for most presentations of neuroborreliosis. Serological tests have improved significantly. Several studies have confirmed that patients treated for early Lyme borreliosis have good overall long-term outcomes. Studies of patients with persistent symptoms following treatment have not shown evidence for active infection or for sustained benefit from prolonged antibiotic treatment. SUMMARY: Greater efforts are needed to provide education for prevention and early diagnosis to avoid late complications. Further improvements in diagnostic tests would be welcomed. More research is required to assess the causes and management of post-Lyme symptoms. SN - 1473-6527 UR - https://www.unboundmedicine.com/medline/citation/20407371/full_citation L2 - http://dx.doi.org/10.1097/QCO.0b013e32833890e2 DB - PRIME DP - Unbound Medicine ER -