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Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides.
Trends Microbiol. 2010 Jul; 18(7):298-307.TM

Abstract

As the sole nutrition provided to infants, bioactive molecules dissolved in milk influence the development of our gut microbiota. Accordingly, human milk oligosaccharides (HMOs) are minimally digested by the infant and persist to negatively and positively regulate gut microbiota. Infant-type bifidobacteria utilize these soluble carbohydrate oligomers by convergent mechanisms. Bifidobacterium longum subsp. infantis efficiently consumes several small mass HMOs and possesses a large gene cluster and other loci dedicated to HMO metabolism. In contrast, adult-associated bifidobacteria such as the closely related B. longum subsp. longum are deficient for HMO utilization, although they retain the capacity to ferment plant oligosaccharides and constituent pentose sugars. Thus, the ability to subsist on HMO could demark infant-associated ecotypes potentially adapted to colonize the nursing infant.

Authors+Show Affiliations

Microbiology Graduate Group, University of California, Davis, CA 95616, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

20409714

Citation

Sela, David A., and David A. Mills. "Nursing Our Microbiota: Molecular Linkages Between Bifidobacteria and Milk Oligosaccharides." Trends in Microbiology, vol. 18, no. 7, 2010, pp. 298-307.
Sela DA, Mills DA. Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides. Trends Microbiol. 2010;18(7):298-307.
Sela, D. A., & Mills, D. A. (2010). Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides. Trends in Microbiology, 18(7), 298-307. https://doi.org/10.1016/j.tim.2010.03.008
Sela DA, Mills DA. Nursing Our Microbiota: Molecular Linkages Between Bifidobacteria and Milk Oligosaccharides. Trends Microbiol. 2010;18(7):298-307. PubMed PMID: 20409714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides. AU - Sela,David A, AU - Mills,David A, Y1 - 2010/04/19/ PY - 2009/11/20/received PY - 2010/03/15/revised PY - 2010/03/23/accepted PY - 2010/4/23/entrez PY - 2010/4/23/pubmed PY - 2010/10/12/medline SP - 298 EP - 307 JF - Trends in microbiology JO - Trends Microbiol VL - 18 IS - 7 N2 - As the sole nutrition provided to infants, bioactive molecules dissolved in milk influence the development of our gut microbiota. Accordingly, human milk oligosaccharides (HMOs) are minimally digested by the infant and persist to negatively and positively regulate gut microbiota. Infant-type bifidobacteria utilize these soluble carbohydrate oligomers by convergent mechanisms. Bifidobacterium longum subsp. infantis efficiently consumes several small mass HMOs and possesses a large gene cluster and other loci dedicated to HMO metabolism. In contrast, adult-associated bifidobacteria such as the closely related B. longum subsp. longum are deficient for HMO utilization, although they retain the capacity to ferment plant oligosaccharides and constituent pentose sugars. Thus, the ability to subsist on HMO could demark infant-associated ecotypes potentially adapted to colonize the nursing infant. SN - 1878-4380 UR - https://www.unboundmedicine.com/medline/citation/20409714/Nursing_our_microbiota:_molecular_linkages_between_bifidobacteria_and_milk_oligosaccharides_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0966-842X(10)00055-7 DB - PRIME DP - Unbound Medicine ER -