Tags

Type your tag names separated by a space and hit enter

Intestinal transglutaminase 2 specific antibody deposits in non-responsive coeliac disease.
Dig Liver Dis. 2010 Oct; 42(10):692-7.DL

Abstract

BACKGROUND AND AIMS

The diagnosis of coeliac disease is problematic in individuals not responding to a gluten-free diet. Small-bowel villous atrophy occurs in other enteropathies and non-responsive patients are often seronegative. We investigated whether small-bowel mucosal transglutaminase-2 specific autoantibody deposits distinguish non-responsive coeliac disease from other enteropathies.

METHODS

Small-bowel mucosal autoantibody deposits were determined in 27 non-responsive, 28 responsive coeliac patients and 10 controls with other enteropathies. Of the non-responsive coeliac patients six were adhering poorly and 21 strictly to the diet; six of the 21 had enteropathy-associated lymphoma, five refractory coeliac disease and 10 otherwise persistent villous atrophy. The presence of mucosal autoantibody deposits was compared to serology, villous morphology, densities of intraepithelial lymphocytes (IELs) and markers of refractory coeliac disease.

RESULTS

Twenty out of 21 well-adhering, all six poorly adhering non-responsive and all 28 untreated responsive coeliac patients had small-bowel mucosal autoantibody deposits present, while controls with other enteropathies were negative. Small-bowel mucosal autoantibody deposits were more accurate in detecting coeliac disease than serology or IEL densities. Refractory coeliac markers revealed only cases with the most severe condition.

CONCLUSIONS

Small-bowel mucosal autoantibody deposits differentiate coeliac disease from other enteropathies, enabling the design of appropriate therapeutic strategies.

Authors+Show Affiliations

Pediatric Research Center and Medical School, University of Tampere, FIN-33014 Tampere, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20409763

Citation

Koskinen, Outi, et al. "Intestinal Transglutaminase 2 Specific Antibody Deposits in Non-responsive Coeliac Disease." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 42, no. 10, 2010, pp. 692-7.
Koskinen O, Lindfors K, Collin P, et al. Intestinal transglutaminase 2 specific antibody deposits in non-responsive coeliac disease. Dig Liver Dis. 2010;42(10):692-7.
Koskinen, O., Lindfors, K., Collin, P., Peräaho, M., Laurila, K., Woolley, N., Partanen, J., Mäki, M., & Kaukinen, K. (2010). Intestinal transglutaminase 2 specific antibody deposits in non-responsive coeliac disease. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 42(10), 692-7. https://doi.org/10.1016/j.dld.2010.03.008
Koskinen O, et al. Intestinal Transglutaminase 2 Specific Antibody Deposits in Non-responsive Coeliac Disease. Dig Liver Dis. 2010;42(10):692-7. PubMed PMID: 20409763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intestinal transglutaminase 2 specific antibody deposits in non-responsive coeliac disease. AU - Koskinen,Outi, AU - Lindfors,Katri, AU - Collin,Pekka, AU - Peräaho,Markku, AU - Laurila,Kaija, AU - Woolley,Niina, AU - Partanen,Jukka, AU - Mäki,Markku, AU - Kaukinen,Katri, Y1 - 2010/04/20/ PY - 2010/01/07/received PY - 2010/02/26/revised PY - 2010/03/09/accepted PY - 2010/4/23/entrez PY - 2010/4/23/pubmed PY - 2011/1/28/medline SP - 692 EP - 7 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 42 IS - 10 N2 - BACKGROUND AND AIMS: The diagnosis of coeliac disease is problematic in individuals not responding to a gluten-free diet. Small-bowel villous atrophy occurs in other enteropathies and non-responsive patients are often seronegative. We investigated whether small-bowel mucosal transglutaminase-2 specific autoantibody deposits distinguish non-responsive coeliac disease from other enteropathies. METHODS: Small-bowel mucosal autoantibody deposits were determined in 27 non-responsive, 28 responsive coeliac patients and 10 controls with other enteropathies. Of the non-responsive coeliac patients six were adhering poorly and 21 strictly to the diet; six of the 21 had enteropathy-associated lymphoma, five refractory coeliac disease and 10 otherwise persistent villous atrophy. The presence of mucosal autoantibody deposits was compared to serology, villous morphology, densities of intraepithelial lymphocytes (IELs) and markers of refractory coeliac disease. RESULTS: Twenty out of 21 well-adhering, all six poorly adhering non-responsive and all 28 untreated responsive coeliac patients had small-bowel mucosal autoantibody deposits present, while controls with other enteropathies were negative. Small-bowel mucosal autoantibody deposits were more accurate in detecting coeliac disease than serology or IEL densities. Refractory coeliac markers revealed only cases with the most severe condition. CONCLUSIONS: Small-bowel mucosal autoantibody deposits differentiate coeliac disease from other enteropathies, enabling the design of appropriate therapeutic strategies. SN - 1878-3562 UR - https://www.unboundmedicine.com/medline/citation/20409763/Intestinal_transglutaminase_2_specific_antibody_deposits_in_non_responsive_coeliac_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(10)00099-X DB - PRIME DP - Unbound Medicine ER -