Tags

Type your tag names separated by a space and hit enter

Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study.
J Intern Med. 2010 Sep; 268(3):265-78.JI

Abstract

OBJECTIVES

To examine the efficacy of the pain inhibitory systems in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) during two different types of exercise and to examine whether the (mal)functioning of pain inhibitory systems is associated with symptom increases following exercise.

DESIGN

A controlled experimental study.

SETTING AND SUBJECTS

Twenty-two women with ME/CFS and 22 healthy sedentary controls were studied at the Department of Human Physiology, Vrije Universiteit Brussel.

INTERVENTIONS

All subjects performed a submaximal exercise test and a self-paced, physiologically limited exercise test on a cycle ergometer. The exercise tests were undertaken with continuous cardiorespiratory monitoring. Before and after the exercise bouts, subjects filled out questionnaires to assess health status, and underwent pressure pain threshold measurements. Throughout the study, subjects' activity levels were assessed using accelerometry.

RESULTS

In patients with ME/CFS, pain thresholds decreased following both types of exercise, whereas they increased in healthy subjects. This was accompanied by a worsening of the ME/CFS symptom complex post-exercise. Decreased pressure thresholds during submaximal exercise were associated with postexertional fatigue in the ME/CFS group (r = 0.454; P = 0.034).

CONCLUSIONS

These observations indicate the presence of abnormal central pain processing during exercise in patients with ME/CFS and demonstrate that both submaximal exercise and self-paced, physiologically limited exercise trigger postexertional malaise in these patients. Further study is required to identify specific modes and intensity of exercise that can be performed in people with ME/CFS without exacerbating symptoms.

Authors+Show Affiliations

Department of Human Physiology, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20412374

Citation

Van Oosterwijck, J, et al. "Pain Inhibition and Postexertional Malaise in Myalgic Encephalomyelitis/chronic Fatigue Syndrome: an Experimental Study." Journal of Internal Medicine, vol. 268, no. 3, 2010, pp. 265-78.
Van Oosterwijck J, Nijs J, Meeus M, et al. Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study. J Intern Med. 2010;268(3):265-78.
Van Oosterwijck, J., Nijs, J., Meeus, M., Lefever, I., Huybrechts, L., Lambrecht, L., & Paul, L. (2010). Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study. Journal of Internal Medicine, 268(3), 265-78. https://doi.org/10.1111/j.1365-2796.2010.02228.x
Van Oosterwijck J, et al. Pain Inhibition and Postexertional Malaise in Myalgic Encephalomyelitis/chronic Fatigue Syndrome: an Experimental Study. J Intern Med. 2010;268(3):265-78. PubMed PMID: 20412374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study. AU - Van Oosterwijck,J, AU - Nijs,J, AU - Meeus,M, AU - Lefever,I, AU - Huybrechts,L, AU - Lambrecht,L, AU - Paul,L, Y1 - 2010/03/03/ PY - 2010/4/24/entrez PY - 2010/4/24/pubmed PY - 2010/9/14/medline SP - 265 EP - 78 JF - Journal of internal medicine JO - J Intern Med VL - 268 IS - 3 N2 - OBJECTIVES: To examine the efficacy of the pain inhibitory systems in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) during two different types of exercise and to examine whether the (mal)functioning of pain inhibitory systems is associated with symptom increases following exercise. DESIGN: A controlled experimental study. SETTING AND SUBJECTS: Twenty-two women with ME/CFS and 22 healthy sedentary controls were studied at the Department of Human Physiology, Vrije Universiteit Brussel. INTERVENTIONS: All subjects performed a submaximal exercise test and a self-paced, physiologically limited exercise test on a cycle ergometer. The exercise tests were undertaken with continuous cardiorespiratory monitoring. Before and after the exercise bouts, subjects filled out questionnaires to assess health status, and underwent pressure pain threshold measurements. Throughout the study, subjects' activity levels were assessed using accelerometry. RESULTS: In patients with ME/CFS, pain thresholds decreased following both types of exercise, whereas they increased in healthy subjects. This was accompanied by a worsening of the ME/CFS symptom complex post-exercise. Decreased pressure thresholds during submaximal exercise were associated with postexertional fatigue in the ME/CFS group (r = 0.454; P = 0.034). CONCLUSIONS: These observations indicate the presence of abnormal central pain processing during exercise in patients with ME/CFS and demonstrate that both submaximal exercise and self-paced, physiologically limited exercise trigger postexertional malaise in these patients. Further study is required to identify specific modes and intensity of exercise that can be performed in people with ME/CFS without exacerbating symptoms. SN - 1365-2796 UR - https://www.unboundmedicine.com/medline/citation/20412374/Pain_inhibition_and_postexertional_malaise_in_myalgic_encephalomyelitis/chronic_fatigue_syndrome:_an_experimental_study_ L2 - https://doi.org/10.1111/j.1365-2796.2010.02228.x DB - PRIME DP - Unbound Medicine ER -