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Attenuation of radiation- and chemoradiation-induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07).
Oral Dis 2010; 16(7):655-60OD

Abstract

OBJECTIVE

To evaluate the efficacy of a novel immunomodulating peptide (SCV-07) in attenuating the course of radiation-induced mucositis in an established animal model of oral mucositis (OM).

MATERIAL AND METHODS

In three separate experiments, golden Syrian hamsters received either an acute radiation challenge to the buccal mucosa of eight fractionated doses of 7.5 Gy of radiation over a 2-week-period, or a combination of acute radiation and cisplatin. In each experiment, animals were treated with varying doses or schedules of SCV-07 or placebo. OM was scored in a blinded fashion using digital images obtained during the experimental period.

RESULTS

We found that SCV-07 reduced the severity and duration of both acute and fractionated radiation-induced OM. Similarly, when radiation and chemotherapy were used to induce OM, treatment with SCV-07 significantly reduced the duration of ulcerative OM. The therapeutic benefit was dependent on both dose and schedule of administration.

CONCLUSION

Taken together, we found SCV-07 was able to modify the duration and severity of oral mucositis and was dependent on schedule and dose.

Authors+Show Affiliations

Biomodels, L.L.C. Watertown, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20412446

Citation

Watkins, B, et al. "Attenuation of Radiation- and Chemoradiation-induced Mucositis Using gamma-D-glutamyl-L-tryptophan (SCV-07)." Oral Diseases, vol. 16, no. 7, 2010, pp. 655-60.
Watkins B, Pouliot K, Fey E, et al. Attenuation of radiation- and chemoradiation-induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07). Oral Dis. 2010;16(7):655-60.
Watkins, B., Pouliot, K., Fey, E., Tuthill, C., & Sonis, S. (2010). Attenuation of radiation- and chemoradiation-induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07). Oral Diseases, 16(7), pp. 655-60. doi:10.1111/j.1601-0825.2010.01671.x.
Watkins B, et al. Attenuation of Radiation- and Chemoradiation-induced Mucositis Using gamma-D-glutamyl-L-tryptophan (SCV-07). Oral Dis. 2010;16(7):655-60. PubMed PMID: 20412446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attenuation of radiation- and chemoradiation-induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07). AU - Watkins,B, AU - Pouliot,K, AU - Fey,E, AU - Tuthill,C, AU - Sonis,S, PY - 2010/4/24/entrez PY - 2010/4/24/pubmed PY - 2010/12/29/medline SP - 655 EP - 60 JF - Oral diseases JO - Oral Dis VL - 16 IS - 7 N2 - OBJECTIVE: To evaluate the efficacy of a novel immunomodulating peptide (SCV-07) in attenuating the course of radiation-induced mucositis in an established animal model of oral mucositis (OM). MATERIAL AND METHODS: In three separate experiments, golden Syrian hamsters received either an acute radiation challenge to the buccal mucosa of eight fractionated doses of 7.5 Gy of radiation over a 2-week-period, or a combination of acute radiation and cisplatin. In each experiment, animals were treated with varying doses or schedules of SCV-07 or placebo. OM was scored in a blinded fashion using digital images obtained during the experimental period. RESULTS: We found that SCV-07 reduced the severity and duration of both acute and fractionated radiation-induced OM. Similarly, when radiation and chemotherapy were used to induce OM, treatment with SCV-07 significantly reduced the duration of ulcerative OM. The therapeutic benefit was dependent on both dose and schedule of administration. CONCLUSION: Taken together, we found SCV-07 was able to modify the duration and severity of oral mucositis and was dependent on schedule and dose. SN - 1601-0825 UR - https://www.unboundmedicine.com/medline/citation/20412446/Attenuation_of_radiation__and_chemoradiation_induced_mucositis_using_gamma_D_glutamyl_L_tryptophan__SCV_07__ L2 - https://doi.org/10.1111/j.1601-0825.2010.01671.x DB - PRIME DP - Unbound Medicine ER -