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Lung transplantation with donation after cardiac death donors: long-term follow-up in a single center.
J Thorac Cardiovasc Surg. 2010 May; 139(5):1306-15.JT

Abstract

OBJECTIVE

We sought to examine long-term outcomes at the University of Wisconsin for all lung transplant recipients who received lungs from donation after cardiac death donors since the initiation of this program in 1993.

METHODS

Eighteen (4.2%) of the 424 lung transplantations performed in 406 patients between January 1993 and April 2009 used lungs from donation after cardiac death donors. Outcomes for this recipient cohort were compared with those for recipients who received organs from brain-dead donors.

RESULTS

Warm ischemic time (from withdrawal of support to reperfusion of organs) was 30 +/- 17 minutes (11-93 minutes). The patient survival rates in the donation after cardiac death group (DCD group) at 1, 3, and 5 years were 88.1% +/- 7.9%, 81.9% +/- 9.5%, and 81.9% +/- 9.5%, respectively. These survival rates were not different from those of the brain-dead donor group (BDD group, P = .66). The incidence of primary graft dysfunction in the DCD group was similar to that of the BDD group (P = .59). However, the incidence of airway complications was somewhat higher in the DCD group. Freedom from bronchiolitis obliterans syndrome at 1, 3, and 5 years in the DCD group was 80.4% +/- 10.2%, 80.4% +/- 10.2%, and 72.3% +/- 11.9%, respectively, and did not differ from the incidence of bronchiolitis obliterans syndrome in the BDD group (P = .59).

CONCLUSIONS

Our data show that the long-term patient and graft survival rates after donation after cardiac death lung transplantation were equivalent to those after brain-dead donor lung transplantation. Our findings suggest that the use of donation after cardiac death donors can safely and substantially expand the donor pool for lung transplantation.

Authors+Show Affiliations

Department of Surgery, Division of Cardiothoracic Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wis., USA. deoliveira@surgery.wisc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20412963

Citation

De Oliveira, Nilto C., et al. "Lung Transplantation With Donation After Cardiac Death Donors: Long-term Follow-up in a Single Center." The Journal of Thoracic and Cardiovascular Surgery, vol. 139, no. 5, 2010, pp. 1306-15.
De Oliveira NC, Osaki S, Maloney JD, et al. Lung transplantation with donation after cardiac death donors: long-term follow-up in a single center. J Thorac Cardiovasc Surg. 2010;139(5):1306-15.
De Oliveira, N. C., Osaki, S., Maloney, J. D., Meyer, K. C., Kohmoto, T., D'Alessandro, A. M., & Love, R. B. (2010). Lung transplantation with donation after cardiac death donors: long-term follow-up in a single center. The Journal of Thoracic and Cardiovascular Surgery, 139(5), 1306-15. https://doi.org/10.1016/j.jtcvs.2010.02.004
De Oliveira NC, et al. Lung Transplantation With Donation After Cardiac Death Donors: Long-term Follow-up in a Single Center. J Thorac Cardiovasc Surg. 2010;139(5):1306-15. PubMed PMID: 20412963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lung transplantation with donation after cardiac death donors: long-term follow-up in a single center. AU - De Oliveira,Nilto C, AU - Osaki,Satoru, AU - Maloney,James D, AU - Meyer,Keith C, AU - Kohmoto,Takushi, AU - D'Alessandro,Anthony M, AU - Love,Robert B, PY - 2009/05/01/received PY - 2010/01/12/revised PY - 2010/02/02/accepted PY - 2010/4/24/entrez PY - 2010/4/24/pubmed PY - 2010/5/7/medline SP - 1306 EP - 15 JF - The Journal of thoracic and cardiovascular surgery JO - J. Thorac. Cardiovasc. Surg. VL - 139 IS - 5 N2 - OBJECTIVE: We sought to examine long-term outcomes at the University of Wisconsin for all lung transplant recipients who received lungs from donation after cardiac death donors since the initiation of this program in 1993. METHODS: Eighteen (4.2%) of the 424 lung transplantations performed in 406 patients between January 1993 and April 2009 used lungs from donation after cardiac death donors. Outcomes for this recipient cohort were compared with those for recipients who received organs from brain-dead donors. RESULTS: Warm ischemic time (from withdrawal of support to reperfusion of organs) was 30 +/- 17 minutes (11-93 minutes). The patient survival rates in the donation after cardiac death group (DCD group) at 1, 3, and 5 years were 88.1% +/- 7.9%, 81.9% +/- 9.5%, and 81.9% +/- 9.5%, respectively. These survival rates were not different from those of the brain-dead donor group (BDD group, P = .66). The incidence of primary graft dysfunction in the DCD group was similar to that of the BDD group (P = .59). However, the incidence of airway complications was somewhat higher in the DCD group. Freedom from bronchiolitis obliterans syndrome at 1, 3, and 5 years in the DCD group was 80.4% +/- 10.2%, 80.4% +/- 10.2%, and 72.3% +/- 11.9%, respectively, and did not differ from the incidence of bronchiolitis obliterans syndrome in the BDD group (P = .59). CONCLUSIONS: Our data show that the long-term patient and graft survival rates after donation after cardiac death lung transplantation were equivalent to those after brain-dead donor lung transplantation. Our findings suggest that the use of donation after cardiac death donors can safely and substantially expand the donor pool for lung transplantation. SN - 1097-685X UR - https://www.unboundmedicine.com/medline/citation/20412963/Lung_transplantation_with_donation_after_cardiac_death_donors:_long_term_follow_up_in_a_single_center_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-5223(10)00124-8 DB - PRIME DP - Unbound Medicine ER -