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Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder.
J Affect Disord 2010; 126(1-2):303-11JA

Abstract

BACKGROUND

Epidemiological and controlled intervention trials suggest that omega-3 (n-3) fatty acid deficiency represents a reversible risk factor for recurrent affective disorders. However, there is limited comparative information available regarding the n-3 fatty acid status and associated mood symptoms in medication-free patients with major depressive disorder (MDD) and bipolar disorder (BD).

METHODS

The fatty acid composition of erythrocyte membranes from adult male and female healthy controls (n=20) and medication-free patients with MDD (n=20) and BD (n=20) was determined by gas chromatography. Associations with depression and mania symptom severity scores were investigated.

RESULTS

After correction for multiple comparisons, both MDD (-20%) and BD (-32%) patients exhibited significantly lower erythrocyte docosahexaenoic acid (DHA, 22:6n-3) composition relative to healthy controls, and there was a trend for lower DHA in BD patients relative to MDD patients (-15%, p=0.09). There were no gender differences for DHA in any group. Other n-3 fatty acids, including eicosapentaenoic acid (EPA, 20:5n-3) and docosapentanoic acid (22:5n-3), and n-6 fatty acids, including arachidonic acid (AA, 20:4n-6), were not different. Erythrocyte DHA composition was inversely correlated with indices of delta-9 desaturase activity (18:1/18:0), and associated elevations in oleic acid (18:1n-9) composition, and delta-6 desaturase activity (20:3/18:2). DHA composition was not significantly correlated with depression or mania symptom severity scores.

LIMITATIONS

Data regarding diet and life style factors (cigarette smoking) were not available to evaluate their contribution to the present findings.

CONCLUSIONS

Male and female patients with MDD and BD exhibit selective erythrocyte DHA deficits relative to healthy controls, and this deficit was numerically greater in BD patients. Selective DHA deficits are consistent with impaired peroxisome function, which has implications for n-3 fatty acid interventions aimed at preventing or reversing this deficit.

Authors+Show Affiliations

Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45219-0516, USA. robert.mcnamara@uc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20413162

Citation

McNamara, Robert K., et al. "Selective Deficits in Erythrocyte Docosahexaenoic Acid Composition in Adult Patients With Bipolar Disorder and Major Depressive Disorder." Journal of Affective Disorders, vol. 126, no. 1-2, 2010, pp. 303-11.
McNamara RK, Jandacek R, Rider T, et al. Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder. J Affect Disord. 2010;126(1-2):303-11.
McNamara, R. K., Jandacek, R., Rider, T., Tso, P., Dwivedi, Y., & Pandey, G. N. (2010). Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder. Journal of Affective Disorders, 126(1-2), pp. 303-11. doi:10.1016/j.jad.2010.03.015.
McNamara RK, et al. Selective Deficits in Erythrocyte Docosahexaenoic Acid Composition in Adult Patients With Bipolar Disorder and Major Depressive Disorder. J Affect Disord. 2010;126(1-2):303-11. PubMed PMID: 20413162.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder. AU - McNamara,Robert K, AU - Jandacek,Ronald, AU - Rider,Therese, AU - Tso,Patrick, AU - Dwivedi,Yogesh, AU - Pandey,Ghanshyam N, Y1 - 2010/04/21/ PY - 2009/11/02/received PY - 2010/02/22/revised PY - 2010/03/23/accepted PY - 2010/4/24/entrez PY - 2010/4/24/pubmed PY - 2010/12/28/medline SP - 303 EP - 11 JF - Journal of affective disorders JO - J Affect Disord VL - 126 IS - 1-2 N2 - BACKGROUND: Epidemiological and controlled intervention trials suggest that omega-3 (n-3) fatty acid deficiency represents a reversible risk factor for recurrent affective disorders. However, there is limited comparative information available regarding the n-3 fatty acid status and associated mood symptoms in medication-free patients with major depressive disorder (MDD) and bipolar disorder (BD). METHODS: The fatty acid composition of erythrocyte membranes from adult male and female healthy controls (n=20) and medication-free patients with MDD (n=20) and BD (n=20) was determined by gas chromatography. Associations with depression and mania symptom severity scores were investigated. RESULTS: After correction for multiple comparisons, both MDD (-20%) and BD (-32%) patients exhibited significantly lower erythrocyte docosahexaenoic acid (DHA, 22:6n-3) composition relative to healthy controls, and there was a trend for lower DHA in BD patients relative to MDD patients (-15%, p=0.09). There were no gender differences for DHA in any group. Other n-3 fatty acids, including eicosapentaenoic acid (EPA, 20:5n-3) and docosapentanoic acid (22:5n-3), and n-6 fatty acids, including arachidonic acid (AA, 20:4n-6), were not different. Erythrocyte DHA composition was inversely correlated with indices of delta-9 desaturase activity (18:1/18:0), and associated elevations in oleic acid (18:1n-9) composition, and delta-6 desaturase activity (20:3/18:2). DHA composition was not significantly correlated with depression or mania symptom severity scores. LIMITATIONS: Data regarding diet and life style factors (cigarette smoking) were not available to evaluate their contribution to the present findings. CONCLUSIONS: Male and female patients with MDD and BD exhibit selective erythrocyte DHA deficits relative to healthy controls, and this deficit was numerically greater in BD patients. Selective DHA deficits are consistent with impaired peroxisome function, which has implications for n-3 fatty acid interventions aimed at preventing or reversing this deficit. SN - 1573-2517 UR - https://www.unboundmedicine.com/medline/citation/20413162/Selective_deficits_in_erythrocyte_docosahexaenoic_acid_composition_in_adult_patients_with_bipolar_disorder_and_major_depressive_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(10)00308-3 DB - PRIME DP - Unbound Medicine ER -