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Cardiac disorders as risk factors for Alzheimer's disease.
J Alzheimers Dis 2010; 20(3):749-63JA

Abstract

Vascular risk factors can play an important role in determining the onset of non-genetic Alzheimer's disease (AD). Most cases of AD are sporadic and late-onset, and a complex interaction between genetic predisposition and vascular risk factors has been proposed. Vascular risk factors for AD include stroke, hypertension, diabetes, homocysteine, smoking, hypercholesterolemia, heart failure and atrial fibrillation; it is possible that these can trigger cerebrovascular dysfunction and AD pathology. Explanations for these associations include the coincidence of common disorders in the elderly where vascular and cerebrovascular disease can precipitate AD, implying that the onset of dementia disease is determined by a synergistic combination of risk factors. In this paper we review the role of cardiovascular risk factors in the pathogenesis of AD and discuss the associated brain mechanisms that can underlie the onset of AD. Cardiovascular diseases are a promising avenue of AD research because they are potentially modifiable in early adult life and provide a new perspective for the prevention of dementia.

Authors+Show Affiliations

Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil. tania alves@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20413875

Citation

de Toledo Ferraz Alves, Tânia Corrêa, et al. "Cardiac Disorders as Risk Factors for Alzheimer's Disease." Journal of Alzheimer's Disease : JAD, vol. 20, no. 3, 2010, pp. 749-63.
de Toledo Ferraz Alves TC, Ferreira LK, Wajngarten M, et al. Cardiac disorders as risk factors for Alzheimer's disease. J Alzheimers Dis. 2010;20(3):749-63.
de Toledo Ferraz Alves, T. C., Ferreira, L. K., Wajngarten, M., & Busatto, G. F. (2010). Cardiac disorders as risk factors for Alzheimer's disease. Journal of Alzheimer's Disease : JAD, 20(3), pp. 749-63. doi:10.3233/JAD-2010-091561.
de Toledo Ferraz Alves TC, et al. Cardiac Disorders as Risk Factors for Alzheimer's Disease. J Alzheimers Dis. 2010;20(3):749-63. PubMed PMID: 20413875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac disorders as risk factors for Alzheimer's disease. AU - de Toledo Ferraz Alves,Tânia Corrêa, AU - Ferreira,Luiz Kobuti, AU - Wajngarten,Mauricio, AU - Busatto,Geraldo F, PY - 2010/4/24/entrez PY - 2010/4/24/pubmed PY - 2010/9/9/medline SP - 749 EP - 63 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 20 IS - 3 N2 - Vascular risk factors can play an important role in determining the onset of non-genetic Alzheimer's disease (AD). Most cases of AD are sporadic and late-onset, and a complex interaction between genetic predisposition and vascular risk factors has been proposed. Vascular risk factors for AD include stroke, hypertension, diabetes, homocysteine, smoking, hypercholesterolemia, heart failure and atrial fibrillation; it is possible that these can trigger cerebrovascular dysfunction and AD pathology. Explanations for these associations include the coincidence of common disorders in the elderly where vascular and cerebrovascular disease can precipitate AD, implying that the onset of dementia disease is determined by a synergistic combination of risk factors. In this paper we review the role of cardiovascular risk factors in the pathogenesis of AD and discuss the associated brain mechanisms that can underlie the onset of AD. Cardiovascular diseases are a promising avenue of AD research because they are potentially modifiable in early adult life and provide a new perspective for the prevention of dementia. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/20413875/Cardiac_disorders_as_risk_factors_for_Alzheimer's_disease_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2010-091561 DB - PRIME DP - Unbound Medicine ER -