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High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age.

Abstract

In this study we investigated the association between plasma levels of eight forms of vitamin E and incidence of Alzheimer's disease (AD) among oldest-old individuals in a population-based setting. A dementia-free sample of 232 subjects aged 80+ years, derived from the Kungsholmen Project, was followed-up to 6 years to detect incident AD. Plasma levels of vitamin E (alpha-, beta-, gamma, and delta-tocopherol; alpha-, beta-, gamma-, and delta-tocotrienol) were measured at baseline. Vitamin E forms-AD association was analyzed with Cox proportional hazard model after adjustment for several potential confounders. Subjects with plasma levels of total tocopherols, total tocotrienols, or total vitamin E in the highest tertile had a reduced risk of developing AD in comparison to persons in the lowest tertile. Multi-adjusted hazard ratios (HRs) and 95% confidence interval (CI) were 0.55 (0.32-0.94) for total tocopherols, 0.46 (0.23-0.92) for total tocotrienols, and 0.55 (0.32-0.94) for total vitamin E. When considering each vitamin E form, the risk of developing AD was reduced only in association with high plasma levels of beta-tocopherol (HR: 0.62, 95% CI 0.39-0.99), whereas alpha-tocopherol, alpha- tocotrienol, and beta-tocotrienol showed only a marginally significant effect in the multiadjusted model [HR (95% CI): alpha-tocopherol: 0.72 (0.48-1.09); alpha-tocotrienol: 0.70 (0.44-1.11); beta-tocotrienol: 0.69 (0.45-1.06)]. In conclusion, high plasma levels of vitamin E are associated with a reduced risk of AD in advanced age. The neuroprotective effect of vitamin E seems to be related to the combination of different forms, rather than to alpha-tocopherol alone, whose efficacy in interventions against AD is currently debated.

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  • Authors+Show Affiliations

    ,

    Aging Research Center, Karolinska Institutet, Stockholm, Sweden. francesca.mangialasche@ki.se

    , , , , ,

    Source

    MeSH

    Aged
    Aged, 80 and over
    Aging
    Alzheimer Disease
    Cholesterol
    Data Collection
    Dementia
    Female
    Humans
    Male
    Neuropsychological Tests
    Nutritional Status
    Population
    Proportional Hazards Models
    Risk Reduction Behavior
    Socioeconomic Factors
    Sweden
    Vitamin E

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20413888

    Citation

    Mangialasche, Francesca, et al. "High Plasma Levels of Vitamin E Forms and Reduced Alzheimer's Disease Risk in Advanced Age." Journal of Alzheimer's Disease : JAD, vol. 20, no. 4, 2010, pp. 1029-37.
    Mangialasche F, Kivipelto M, Mecocci P, et al. High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age. J Alzheimers Dis. 2010;20(4):1029-37.
    Mangialasche, F., Kivipelto, M., Mecocci, P., Rizzuto, D., Palmer, K., Winblad, B., & Fratiglioni, L. (2010). High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age. Journal of Alzheimer's Disease : JAD, 20(4), pp. 1029-37. doi:10.3233/JAD-2010-091450.
    Mangialasche F, et al. High Plasma Levels of Vitamin E Forms and Reduced Alzheimer's Disease Risk in Advanced Age. J Alzheimers Dis. 2010;20(4):1029-37. PubMed PMID: 20413888.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age. AU - Mangialasche,Francesca, AU - Kivipelto,Miia, AU - Mecocci,Patrizia, AU - Rizzuto,Debora, AU - Palmer,Katie, AU - Winblad,Bengt, AU - Fratiglioni,Laura, PY - 2010/4/24/entrez PY - 2010/4/24/pubmed PY - 2010/10/13/medline SP - 1029 EP - 37 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 20 IS - 4 N2 - In this study we investigated the association between plasma levels of eight forms of vitamin E and incidence of Alzheimer's disease (AD) among oldest-old individuals in a population-based setting. A dementia-free sample of 232 subjects aged 80+ years, derived from the Kungsholmen Project, was followed-up to 6 years to detect incident AD. Plasma levels of vitamin E (alpha-, beta-, gamma, and delta-tocopherol; alpha-, beta-, gamma-, and delta-tocotrienol) were measured at baseline. Vitamin E forms-AD association was analyzed with Cox proportional hazard model after adjustment for several potential confounders. Subjects with plasma levels of total tocopherols, total tocotrienols, or total vitamin E in the highest tertile had a reduced risk of developing AD in comparison to persons in the lowest tertile. Multi-adjusted hazard ratios (HRs) and 95% confidence interval (CI) were 0.55 (0.32-0.94) for total tocopherols, 0.46 (0.23-0.92) for total tocotrienols, and 0.55 (0.32-0.94) for total vitamin E. When considering each vitamin E form, the risk of developing AD was reduced only in association with high plasma levels of beta-tocopherol (HR: 0.62, 95% CI 0.39-0.99), whereas alpha-tocopherol, alpha- tocotrienol, and beta-tocotrienol showed only a marginally significant effect in the multiadjusted model [HR (95% CI): alpha-tocopherol: 0.72 (0.48-1.09); alpha-tocotrienol: 0.70 (0.44-1.11); beta-tocotrienol: 0.69 (0.45-1.06)]. In conclusion, high plasma levels of vitamin E are associated with a reduced risk of AD in advanced age. The neuroprotective effect of vitamin E seems to be related to the combination of different forms, rather than to alpha-tocopherol alone, whose efficacy in interventions against AD is currently debated. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/20413888/High_plasma_levels_of_vitamin_E_forms_and_reduced_Alzheimer's_disease_risk_in_advanced_age_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2010-091450 DB - PRIME DP - Unbound Medicine ER -