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High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age.
J Alzheimers Dis 2010; 20(4):1029-37JA

Abstract

In this study we investigated the association between plasma levels of eight forms of vitamin E and incidence of Alzheimer's disease (AD) among oldest-old individuals in a population-based setting. A dementia-free sample of 232 subjects aged 80+ years, derived from the Kungsholmen Project, was followed-up to 6 years to detect incident AD. Plasma levels of vitamin E (alpha-, beta-, gamma, and delta-tocopherol; alpha-, beta-, gamma-, and delta-tocotrienol) were measured at baseline. Vitamin E forms-AD association was analyzed with Cox proportional hazard model after adjustment for several potential confounders. Subjects with plasma levels of total tocopherols, total tocotrienols, or total vitamin E in the highest tertile had a reduced risk of developing AD in comparison to persons in the lowest tertile. Multi-adjusted hazard ratios (HRs) and 95% confidence interval (CI) were 0.55 (0.32-0.94) for total tocopherols, 0.46 (0.23-0.92) for total tocotrienols, and 0.55 (0.32-0.94) for total vitamin E. When considering each vitamin E form, the risk of developing AD was reduced only in association with high plasma levels of beta-tocopherol (HR: 0.62, 95% CI 0.39-0.99), whereas alpha-tocopherol, alpha- tocotrienol, and beta-tocotrienol showed only a marginally significant effect in the multiadjusted model [HR (95% CI): alpha-tocopherol: 0.72 (0.48-1.09); alpha-tocotrienol: 0.70 (0.44-1.11); beta-tocotrienol: 0.69 (0.45-1.06)]. In conclusion, high plasma levels of vitamin E are associated with a reduced risk of AD in advanced age. The neuroprotective effect of vitamin E seems to be related to the combination of different forms, rather than to alpha-tocopherol alone, whose efficacy in interventions against AD is currently debated.

Authors+Show Affiliations

Aging Research Center, Karolinska Institutet, Stockholm, Sweden. francesca.mangialasche@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20413888

Citation

Mangialasche, Francesca, et al. "High Plasma Levels of Vitamin E Forms and Reduced Alzheimer's Disease Risk in Advanced Age." Journal of Alzheimer's Disease : JAD, vol. 20, no. 4, 2010, pp. 1029-37.
Mangialasche F, Kivipelto M, Mecocci P, et al. High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age. J Alzheimers Dis. 2010;20(4):1029-37.
Mangialasche, F., Kivipelto, M., Mecocci, P., Rizzuto, D., Palmer, K., Winblad, B., & Fratiglioni, L. (2010). High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age. Journal of Alzheimer's Disease : JAD, 20(4), pp. 1029-37. doi:10.3233/JAD-2010-091450.
Mangialasche F, et al. High Plasma Levels of Vitamin E Forms and Reduced Alzheimer's Disease Risk in Advanced Age. J Alzheimers Dis. 2010;20(4):1029-37. PubMed PMID: 20413888.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age. AU - Mangialasche,Francesca, AU - Kivipelto,Miia, AU - Mecocci,Patrizia, AU - Rizzuto,Debora, AU - Palmer,Katie, AU - Winblad,Bengt, AU - Fratiglioni,Laura, PY - 2010/4/24/entrez PY - 2010/4/24/pubmed PY - 2010/10/13/medline SP - 1029 EP - 37 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 20 IS - 4 N2 - In this study we investigated the association between plasma levels of eight forms of vitamin E and incidence of Alzheimer's disease (AD) among oldest-old individuals in a population-based setting. A dementia-free sample of 232 subjects aged 80+ years, derived from the Kungsholmen Project, was followed-up to 6 years to detect incident AD. Plasma levels of vitamin E (alpha-, beta-, gamma, and delta-tocopherol; alpha-, beta-, gamma-, and delta-tocotrienol) were measured at baseline. Vitamin E forms-AD association was analyzed with Cox proportional hazard model after adjustment for several potential confounders. Subjects with plasma levels of total tocopherols, total tocotrienols, or total vitamin E in the highest tertile had a reduced risk of developing AD in comparison to persons in the lowest tertile. Multi-adjusted hazard ratios (HRs) and 95% confidence interval (CI) were 0.55 (0.32-0.94) for total tocopherols, 0.46 (0.23-0.92) for total tocotrienols, and 0.55 (0.32-0.94) for total vitamin E. When considering each vitamin E form, the risk of developing AD was reduced only in association with high plasma levels of beta-tocopherol (HR: 0.62, 95% CI 0.39-0.99), whereas alpha-tocopherol, alpha- tocotrienol, and beta-tocotrienol showed only a marginally significant effect in the multiadjusted model [HR (95% CI): alpha-tocopherol: 0.72 (0.48-1.09); alpha-tocotrienol: 0.70 (0.44-1.11); beta-tocotrienol: 0.69 (0.45-1.06)]. In conclusion, high plasma levels of vitamin E are associated with a reduced risk of AD in advanced age. The neuroprotective effect of vitamin E seems to be related to the combination of different forms, rather than to alpha-tocopherol alone, whose efficacy in interventions against AD is currently debated. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/20413888/High_plasma_levels_of_vitamin_E_forms_and_reduced_Alzheimer's_disease_risk_in_advanced_age_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2010-091450 DB - PRIME DP - Unbound Medicine ER -