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The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat.
J Alzheimers Dis 2010; 21(1):207-19JA

Abstract

Cognitive impairment and Alzheimer's disease are linked with intake of a Western diet, characterized by high levels of saturated fats and simple carbohydrates. In rats, these dietary components have been shown to disrupt hippocampal-dependent learning and memory processes, particularly those involving spatial memory. Using a rat model, the present research assessed the degree to which consumption of a high-energy (HE) diet, similar to those found in modern Western cultures, produces a selective impairment in hippocampal function as opposed to a more global cognitive disruption. Learning and memory performance was examined following 90-day consumption of an HE-diet in three nonspatial discrimination learning problems that differed with respect to their dependence on the integrity of the hippocampus. The results showed that consumption of the HE-diet impaired performance in a hippocampal-dependent feature negative discrimination problem relative to chow-fed controls, whereas performance was spared on two discrimination problems that do not rely on the hippocampus. To explore the mechanism whereby consuming HE-diets impairs cognitive function, we investigated the effect of HE-diets on the integrity of the blood-brain barrier (BBB). We found that HE-diet consumption produced a decrease in mRNA expression of tight junction proteins, particularly Claudin-5 and -12, in the choroid plexus and the BBB. Consequently, an increased blood-to-brain permeability of sodium fluorescein was observed in the hippocampus, but not in the striatum and prefrontal cortex following HE-diet access. These results indicate that hippocampal function may be particularly vulnerable to disruption by HE-diets, and this disruption may be related to impaired BBB integrity.

Authors+Show Affiliations

Department of Psychological Sciences, Purdue University, West Lafayette, IN 19104-6241, USA. kanoski@sas.upenn.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20413889

Citation

Kanoski, Scott E., et al. "The Effects of a High-energy Diet On Hippocampal Function and Blood-brain Barrier Integrity in the Rat." Journal of Alzheimer's Disease : JAD, vol. 21, no. 1, 2010, pp. 207-19.
Kanoski SE, Zhang Y, Zheng W, et al. The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. J Alzheimers Dis. 2010;21(1):207-19.
Kanoski, S. E., Zhang, Y., Zheng, W., & Davidson, T. L. (2010). The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. Journal of Alzheimer's Disease : JAD, 21(1), pp. 207-19. doi:10.3233/JAD-2010-091414.
Kanoski SE, et al. The Effects of a High-energy Diet On Hippocampal Function and Blood-brain Barrier Integrity in the Rat. J Alzheimers Dis. 2010;21(1):207-19. PubMed PMID: 20413889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. AU - Kanoski,Scott E, AU - Zhang,Yanshu, AU - Zheng,Wei, AU - Davidson,Terry L, PY - 2010/4/24/entrez PY - 2010/4/24/pubmed PY - 2010/11/3/medline SP - 207 EP - 19 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 21 IS - 1 N2 - Cognitive impairment and Alzheimer's disease are linked with intake of a Western diet, characterized by high levels of saturated fats and simple carbohydrates. In rats, these dietary components have been shown to disrupt hippocampal-dependent learning and memory processes, particularly those involving spatial memory. Using a rat model, the present research assessed the degree to which consumption of a high-energy (HE) diet, similar to those found in modern Western cultures, produces a selective impairment in hippocampal function as opposed to a more global cognitive disruption. Learning and memory performance was examined following 90-day consumption of an HE-diet in three nonspatial discrimination learning problems that differed with respect to their dependence on the integrity of the hippocampus. The results showed that consumption of the HE-diet impaired performance in a hippocampal-dependent feature negative discrimination problem relative to chow-fed controls, whereas performance was spared on two discrimination problems that do not rely on the hippocampus. To explore the mechanism whereby consuming HE-diets impairs cognitive function, we investigated the effect of HE-diets on the integrity of the blood-brain barrier (BBB). We found that HE-diet consumption produced a decrease in mRNA expression of tight junction proteins, particularly Claudin-5 and -12, in the choroid plexus and the BBB. Consequently, an increased blood-to-brain permeability of sodium fluorescein was observed in the hippocampus, but not in the striatum and prefrontal cortex following HE-diet access. These results indicate that hippocampal function may be particularly vulnerable to disruption by HE-diets, and this disruption may be related to impaired BBB integrity. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/20413889/The_effects_of_a_high_energy_diet_on_hippocampal_function_and_blood_brain_barrier_integrity_in_the_rat_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2010-091414 DB - PRIME DP - Unbound Medicine ER -