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LRRK2 G2019S in the North African population: a review.
Eur Neurol. 2010; 63(6):321-5.EN

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder, for which environmental and/or genetic factors are postulated as possible causes. Over the past decade there has been a substantial increase in the knowledge of the genetics of PD. Mutations in Leucine-rich repeat kinase 2 (LRRK2) are the most frequent genetic causes of PD, and the common G2019S mutation has been identified in various ethnic groups with variable frequency. The aim of this article is to review the literature relating to LRRK2 G2019S in the North African population, which is composed of two main ethnic groups - the Berbers and the Arabs. The frequency of LRRK2 G2019S is 30-41% in familial PD and 30-39% in apparently sporadic PD in North Africa. Within healthy controls, Moroccan Berbers appear to have the highest carrier frequency at 3.3%. The majority of the available studies do not draw a clear distinction between the two ethnic groups, despite the distinct possibility that their ancestral origins are different. Further research looking at the respective prevalences of LRRK2 G2019S in Berbers and Arabs, and in different Arab populations, seems justified.

Authors+Show Affiliations

Department of Neurology, New Cross Hospital, Wolverhampton, UK. benamer@doctors.org.ukNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20413974

Citation

Benamer, Hani T S., and Rajith de Silva. "LRRK2 G2019S in the North African Population: a Review." European Neurology, vol. 63, no. 6, 2010, pp. 321-5.
Benamer HT, de Silva R. LRRK2 G2019S in the North African population: a review. Eur Neurol. 2010;63(6):321-5.
Benamer, H. T., & de Silva, R. (2010). LRRK2 G2019S in the North African population: a review. European Neurology, 63(6), 321-5. https://doi.org/10.1159/000279653
Benamer HT, de Silva R. LRRK2 G2019S in the North African Population: a Review. Eur Neurol. 2010;63(6):321-5. PubMed PMID: 20413974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - LRRK2 G2019S in the North African population: a review. AU - Benamer,Hani T S, AU - de Silva,Rajith, Y1 - 2010/04/23/ PY - 2009/09/07/received PY - 2010/01/20/accepted PY - 2010/4/24/entrez PY - 2010/4/24/pubmed PY - 2010/10/14/medline SP - 321 EP - 5 JF - European neurology JO - Eur Neurol VL - 63 IS - 6 N2 - Parkinson's disease (PD) is a common neurodegenerative disorder, for which environmental and/or genetic factors are postulated as possible causes. Over the past decade there has been a substantial increase in the knowledge of the genetics of PD. Mutations in Leucine-rich repeat kinase 2 (LRRK2) are the most frequent genetic causes of PD, and the common G2019S mutation has been identified in various ethnic groups with variable frequency. The aim of this article is to review the literature relating to LRRK2 G2019S in the North African population, which is composed of two main ethnic groups - the Berbers and the Arabs. The frequency of LRRK2 G2019S is 30-41% in familial PD and 30-39% in apparently sporadic PD in North Africa. Within healthy controls, Moroccan Berbers appear to have the highest carrier frequency at 3.3%. The majority of the available studies do not draw a clear distinction between the two ethnic groups, despite the distinct possibility that their ancestral origins are different. Further research looking at the respective prevalences of LRRK2 G2019S in Berbers and Arabs, and in different Arab populations, seems justified. SN - 1421-9913 UR - https://www.unboundmedicine.com/medline/citation/20413974/LRRK2_G2019S_in_the_North_African_population:_a_review_ L2 - https://www.karger.com?DOI=10.1159/000279653 DB - PRIME DP - Unbound Medicine ER -