Tags

Type your tag names separated by a space and hit enter

[Comparison of four methods for measuring glomerular filtration rate by inulin clearance in healthy individuals and patients with renal failure].
Nefrologia. 2010; 30(3):324-30.N

Abstract

BACKGROUND

A proper measurement of renal function is important for diagnosis and stratification of kidney disease. Several methods have been used to predict glomerular filtration rate, however the results have been variable depending on the population studied. We aimed to compare the performances of 4 glomerular filtration rate tests with inulin clearance in patients with chronic renal insufficiency and in healthy subjects.

METHODS

Inulin clearances performed in 51 individuals with stable renal function were selected. For each of them, we computed 4 estimates: the 24-hour creatinine clearance, technetium (99mTc-DTPA) clearance, Cockcroft-Gault and Levey formulas. Their respective performance was assessed by correlation (Pearson's correlation coefficient) and agreement (Bland and Altman method).

RESULTS

Each glomerular filtration rate test closely correlated with inulin clearance. Nevertheless, all GFR tests displayed considerable lack of agreement with lower limits ranging from 15 to 42 ml / min, for comparison with inulin-technetium and inulin with Levey formula, respectively and upper limits of agreement that could range from 20 to 56 ml / min, for comparison with inulin-technetium and Inulin with Levey formula,respectively.

CONCLUSION

The measurement of glomerular filtration rate determined via different methods shows a wide range of variation when compared with inulin clearance, which should be considered in daily clinical practice during the evaluation of renal function.

Authors+Show Affiliations

Departamento de Nefrología, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F. México.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article

Language

spa

PubMed ID

20414326

Citation

Hernández Ocampo, J, et al. "[Comparison of Four Methods for Measuring Glomerular Filtration Rate By Inulin Clearance in Healthy Individuals and Patients With Renal Failure]." Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia, vol. 30, no. 3, 2010, pp. 324-30.
Hernández Ocampo J, Torres Rosales A, Rodríguez Castellanos F. [Comparison of four methods for measuring glomerular filtration rate by inulin clearance in healthy individuals and patients with renal failure]. Nefrologia. 2010;30(3):324-30.
Hernández Ocampo, J., Torres Rosales, A., & Rodríguez Castellanos, F. (2010). [Comparison of four methods for measuring glomerular filtration rate by inulin clearance in healthy individuals and patients with renal failure]. Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia, 30(3), 324-30. https://doi.org/10.3265/Nefrologia.pre2010.Mar.10238
Hernández Ocampo J, Torres Rosales A, Rodríguez Castellanos F. [Comparison of Four Methods for Measuring Glomerular Filtration Rate By Inulin Clearance in Healthy Individuals and Patients With Renal Failure]. Nefrologia. 2010;30(3):324-30. PubMed PMID: 20414326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparison of four methods for measuring glomerular filtration rate by inulin clearance in healthy individuals and patients with renal failure]. AU - Hernández Ocampo,J, AU - Torres Rosales,A, AU - Rodríguez Castellanos,F, Y1 - 2010/03/23/ PY - 2010/03/23/accepted PY - 2010/4/24/entrez PY - 2010/4/24/pubmed PY - 2010/7/9/medline SP - 324 EP - 30 JF - Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia JO - Nefrologia VL - 30 IS - 3 N2 - BACKGROUND: A proper measurement of renal function is important for diagnosis and stratification of kidney disease. Several methods have been used to predict glomerular filtration rate, however the results have been variable depending on the population studied. We aimed to compare the performances of 4 glomerular filtration rate tests with inulin clearance in patients with chronic renal insufficiency and in healthy subjects. METHODS: Inulin clearances performed in 51 individuals with stable renal function were selected. For each of them, we computed 4 estimates: the 24-hour creatinine clearance, technetium (99mTc-DTPA) clearance, Cockcroft-Gault and Levey formulas. Their respective performance was assessed by correlation (Pearson's correlation coefficient) and agreement (Bland and Altman method). RESULTS: Each glomerular filtration rate test closely correlated with inulin clearance. Nevertheless, all GFR tests displayed considerable lack of agreement with lower limits ranging from 15 to 42 ml / min, for comparison with inulin-technetium and inulin with Levey formula, respectively and upper limits of agreement that could range from 20 to 56 ml / min, for comparison with inulin-technetium and Inulin with Levey formula,respectively. CONCLUSION: The measurement of glomerular filtration rate determined via different methods shows a wide range of variation when compared with inulin clearance, which should be considered in daily clinical practice during the evaluation of renal function. SN - 0211-6995 UR - https://www.unboundmedicine.com/medline/citation/20414326/[Comparison_of_four_methods_for_measuring_glomerular_filtration_rate_by_inulin_clearance_in_healthy_individuals_and_patients_with_renal_failure]_ L2 - http://www.revistanefrologia.com/es/linksolver/ft/ivp/0211-6995/30/324 DB - PRIME DP - Unbound Medicine ER -