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[Epidemiological study, pathologic evaluation and prognostic factors of colorectal mucinous vs non-mucinous adenocarcinoma (a series of 196 patients)].
Tunis Med. 2010 Jan; 88(1):12-7.TM

Abstract

BACKGROUND

Colorectal carcinoma is one of the main causes of cancer death in the worldwide with a decrease survival rate in relationship with a later diagnosis of advanced disease.

AIMS

This study highlights the particular epidemiological, clinicopathological and immunohistochemical colorectal cancer profile. Indeed, our results differ markedly from that reported in the literature.

METHODS

We underwent a retro and prospective study interesting 196 patients with colorectal carcinoma diagnosed in the pathological and cytological laboratory of Mongi Slim Hospital (Tunisia). Age at diagnosis, mode of presentation, sex, tumour location, macroscopic and histological features, TNM and Astler Coller stage were assessed and evaluated.

RESULTS

We report here a particular epidemiological pattern which is characterised by younger age of the patients, equally distribution between men and women, predominant sporadic carcinomas and preponderance of rectosigmoid location. The poorer degree of differentiation and mucinous subtype are correlated with an advanced stage. It is also correlated with more frequent vascular embols, neural invasion and metastatic nodes. Furthermore, immunohistochemical analysis of galectin-3 showed a significant difference between mucinous and non mucinous adenocarcinoma.

CONCLUSION

Based on the presented data, the epidemiological pattern and the anatomic distribution especially in the rectosigmoid region suggest diet and lifestyle to be primordial risk factors of colorectal tumorigenesis.

Authors+Show Affiliations

Arfaoui Toumi A
Unité de recherche (M.E.S.R.S): UR03ES04, CHU Mongi Slim La Marsa, Tunisie.
Kriaa Ben Mahmoud L
No affiliation info available
Khiari M
No affiliation info available
Lahmer A
No affiliation info available
Gharbi L
No affiliation info available
Dhraïef M
No affiliation info available
Khalfallah T
No affiliation info available
Regaya Mzabi S
No affiliation info available
Bouraoui S
No affiliation info available

MeSH

AdenocarcinomaAdenocarcinoma, MucinousAdolescentAdultAgedAged, 80 and overBiomarkers, TumorColon, SigmoidColorectal NeoplasmsFemaleGalectin 3HumansImmunohistochemistryMaleMiddle AgedNeoplasm StagingPrognosisProspective StudiesRectumRetrospective StudiesRisk FactorsSurvival AnalysisTunisia

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

20415207

Citation

Arfaoui Toumi, Amira, et al. "[Epidemiological Study, Pathologic Evaluation and Prognostic Factors of Colorectal Mucinous Vs Non-mucinous Adenocarcinoma (a Series of 196 Patients)]." La Tunisie Medicale, vol. 88, no. 1, 2010, pp. 12-7.
Arfaoui Toumi A, Kriaa Ben Mahmoud L, Khiari M, et al. [Epidemiological study, pathologic evaluation and prognostic factors of colorectal mucinous vs non-mucinous adenocarcinoma (a series of 196 patients)]. Tunis Med. 2010;88(1):12-7.
Arfaoui Toumi, A., Kriaa Ben Mahmoud, L., Khiari, M., Lahmer, A., Gharbi, L., Dhraïef, M., Khalfallah, T., Regaya Mzabi, S., & Bouraoui, S. (2010). [Epidemiological study, pathologic evaluation and prognostic factors of colorectal mucinous vs non-mucinous adenocarcinoma (a series of 196 patients)]. La Tunisie Medicale, 88(1), 12-7.
Arfaoui Toumi A, et al. [Epidemiological Study, Pathologic Evaluation and Prognostic Factors of Colorectal Mucinous Vs Non-mucinous Adenocarcinoma (a Series of 196 Patients)]. Tunis Med. 2010;88(1):12-7. PubMed PMID: 20415207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Epidemiological study, pathologic evaluation and prognostic factors of colorectal mucinous vs non-mucinous adenocarcinoma (a series of 196 patients)]. AU - Arfaoui Toumi,Amira, AU - Kriaa Ben Mahmoud,Lilia, AU - Khiari,Meriem, AU - Lahmer,Ahlem, AU - Gharbi,Lasaad, AU - Dhraïef,Monia, AU - Khalfallah,Tahar, AU - Regaya Mzabi,Sabeh, AU - Bouraoui,Saadia, PY - 2010/4/27/entrez PY - 2010/4/27/pubmed PY - 2010/5/28/medline SP - 12 EP - 7 JF - La Tunisie medicale JO - Tunis Med VL - 88 IS - 1 N2 - BACKGROUND: Colorectal carcinoma is one of the main causes of cancer death in the worldwide with a decrease survival rate in relationship with a later diagnosis of advanced disease. AIMS: This study highlights the particular epidemiological, clinicopathological and immunohistochemical colorectal cancer profile. Indeed, our results differ markedly from that reported in the literature. METHODS: We underwent a retro and prospective study interesting 196 patients with colorectal carcinoma diagnosed in the pathological and cytological laboratory of Mongi Slim Hospital (Tunisia). Age at diagnosis, mode of presentation, sex, tumour location, macroscopic and histological features, TNM and Astler Coller stage were assessed and evaluated. RESULTS: We report here a particular epidemiological pattern which is characterised by younger age of the patients, equally distribution between men and women, predominant sporadic carcinomas and preponderance of rectosigmoid location. The poorer degree of differentiation and mucinous subtype are correlated with an advanced stage. It is also correlated with more frequent vascular embols, neural invasion and metastatic nodes. Furthermore, immunohistochemical analysis of galectin-3 showed a significant difference between mucinous and non mucinous adenocarcinoma. CONCLUSION: Based on the presented data, the epidemiological pattern and the anatomic distribution especially in the rectosigmoid region suggest diet and lifestyle to be primordial risk factors of colorectal tumorigenesis. SN - 0041-4131 UR - https://www.unboundmedicine.com/medline/citation/20415207/[Epidemiological_study_pathologic_evaluation_and_prognostic_factors_of_colorectal_mucinous_vs_non_mucinous_adenocarcinoma__a_series_of_196_patients_]_ DB - PRIME DP - Unbound Medicine ER -