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Recipients of vaccine against the 1976 "swine flu" have enhanced neutralization responses to the 2009 novel H1N1 influenza virus.
Clin Infect Dis. 2010 Jun 01; 50(11):1487-92.CI

Abstract

BACKGROUND

. The world is facing a novel H1N1 influenza pandemic. A pandemic scare with a similar influenza virus in 1976 resulted in the vaccination of nearly 45 million persons. We hypothesized that prior receipt of the 1976 "swine flu" vaccine would enhance immune responses to the 2009 novel H1N1 influenza strain.

METHODS.

A prospective, volunteer sample of employees aged > or = 55 years at a children's cancer hospital in August 2009 was assessed for antibody responses to the 2009 pandemic H1N1 influenza virus and the 2008-2009 seasonal H1N1 influenza virus.

RESULTS.

Antibody responses by hemagglutination-inhibition assay were high against both the seasonal influenza virus (89.7% had a titer considered seroprotective) and pandemic H1N1 influenza virus (88.8% had a seroprotective titer). These antibodies were effective at neutralizing the seasonal H1N1 influenza virus in 68.1% of participants (titer > or = 40), but only 18.1% had detectable neutralizing titers against the pandemic H1N1 influenza virus. Of 116 participants, 46 (39.7%) received the 1976 "swine flu" vaccine. Receipt of this vaccine significantly enhanced neutralization responses; 8 (17.4%) of 46 vaccine recipients had titers > or = 160, compared with only 3 (4.3%) of 70 who did not receive the vaccine (P = .018 by chi(2) test).

CONCLUSIONS.

In this cohort, persons aged > or = 55 years had evidence of robust immunity to the 2008-2009 seasonal H1N1 influenza virus. These antibodies were cross-reactive but nonneutralizing against the 2009 pandemic H1N1 influenza strain. Receipt of a vaccine to a related virus significantly enhanced the neutralization capacity of these responses, suggesting homologous vaccination against the 2009 pandemic H1N1 influenza virus would have a similar effect.

Authors+Show Affiliations

Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA. jon.mccullers@stjude.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20415539

Citation

McCullers, Jonathan A., et al. "Recipients of Vaccine Against the 1976 "swine Flu" Have Enhanced Neutralization Responses to the 2009 Novel H1N1 Influenza Virus." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 50, no. 11, 2010, pp. 1487-92.
McCullers JA, Van De Velde LA, Allison KJ, et al. Recipients of vaccine against the 1976 "swine flu" have enhanced neutralization responses to the 2009 novel H1N1 influenza virus. Clin Infect Dis. 2010;50(11):1487-92.
McCullers, J. A., Van De Velde, L. A., Allison, K. J., Branum, K. C., Webby, R. J., & Flynn, P. M. (2010). Recipients of vaccine against the 1976 "swine flu" have enhanced neutralization responses to the 2009 novel H1N1 influenza virus. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 50(11), 1487-92. https://doi.org/10.1086/652441
McCullers JA, et al. Recipients of Vaccine Against the 1976 "swine Flu" Have Enhanced Neutralization Responses to the 2009 Novel H1N1 Influenza Virus. Clin Infect Dis. 2010 Jun 1;50(11):1487-92. PubMed PMID: 20415539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recipients of vaccine against the 1976 "swine flu" have enhanced neutralization responses to the 2009 novel H1N1 influenza virus. AU - McCullers,Jonathan A, AU - Van De Velde,Lee-Ann, AU - Allison,Kim J, AU - Branum,Kristen C, AU - Webby,Richard J, AU - Flynn,Patricia M, PY - 2010/4/27/entrez PY - 2010/4/27/pubmed PY - 2010/7/20/medline SP - 1487 EP - 92 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 50 IS - 11 N2 - BACKGROUND. The world is facing a novel H1N1 influenza pandemic. A pandemic scare with a similar influenza virus in 1976 resulted in the vaccination of nearly 45 million persons. We hypothesized that prior receipt of the 1976 "swine flu" vaccine would enhance immune responses to the 2009 novel H1N1 influenza strain. METHODS. A prospective, volunteer sample of employees aged > or = 55 years at a children's cancer hospital in August 2009 was assessed for antibody responses to the 2009 pandemic H1N1 influenza virus and the 2008-2009 seasonal H1N1 influenza virus. RESULTS. Antibody responses by hemagglutination-inhibition assay were high against both the seasonal influenza virus (89.7% had a titer considered seroprotective) and pandemic H1N1 influenza virus (88.8% had a seroprotective titer). These antibodies were effective at neutralizing the seasonal H1N1 influenza virus in 68.1% of participants (titer > or = 40), but only 18.1% had detectable neutralizing titers against the pandemic H1N1 influenza virus. Of 116 participants, 46 (39.7%) received the 1976 "swine flu" vaccine. Receipt of this vaccine significantly enhanced neutralization responses; 8 (17.4%) of 46 vaccine recipients had titers > or = 160, compared with only 3 (4.3%) of 70 who did not receive the vaccine (P = .018 by chi(2) test). CONCLUSIONS. In this cohort, persons aged > or = 55 years had evidence of robust immunity to the 2008-2009 seasonal H1N1 influenza virus. These antibodies were cross-reactive but nonneutralizing against the 2009 pandemic H1N1 influenza strain. Receipt of a vaccine to a related virus significantly enhanced the neutralization capacity of these responses, suggesting homologous vaccination against the 2009 pandemic H1N1 influenza virus would have a similar effect. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/20415539/Recipients_of_vaccine_against_the_1976_"swine_flu"_have_enhanced_neutralization_responses_to_the_2009_novel_H1N1_influenza_virus_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/652441 DB - PRIME DP - Unbound Medicine ER -