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Bcl-2 expression in mycosis fungoides before and after PUVA therapy.
Photodermatol Photoimmunol Photomed. 2010 Apr; 26(2):107-9.PP

Abstract

PUVA is the first therapeutic choice in early stages of mycosis fungoides (MF). In this study the effect of PUVA on bcl-2 expression in MF was assessed in 15 patients (three stage Ia and 12 stage Ib) and 10 controls. Two biopsies were taken from each patient before and after 24 sessions of PUVA therapy. Histopathological assessment and immunohistochemical staining for bcl-2 was performed and showed positive bcl-2 staining of lymphocytes in 53% of MF cases (8/15) before PUVA, with no statistically significant difference in the bcl-2 level before and after PUVA therapy (P value 0.3). A statistically significant difference was found in the bcl-2 level between control samples and MF patients' biopsies before (P value 0.02) and after PUVA therapy (P value 0.011). In conclusion, a lack of decline in the bcl-2 level and the absence of clinical or histopathological correlation with the bcl-2 level before and after PUVA therapy in MF patients suggest that PUVA-induced apoptosis in MF cases may occur through pathways other than bcl-2 inhibition.

Authors+Show Affiliations

Department of Dermatology, Kasr El-Aini University Hospital, Cairo University, Cairo, Egypt.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20415745

Citation

Weshahy, Hani, et al. "Bcl-2 Expression in Mycosis Fungoides Before and After PUVA Therapy." Photodermatology, Photoimmunology & Photomedicine, vol. 26, no. 2, 2010, pp. 107-9.
Weshahy H, Mahgoub D, El-Eishy N, et al. Bcl-2 expression in mycosis fungoides before and after PUVA therapy. Photodermatol Photoimmunol Photomed. 2010;26(2):107-9.
Weshahy, H., Mahgoub, D., El-Eishy, N., El-Tawdy, A. M., Bassiouny, D. A., Hunter, N., & Hindawi, A. (2010). Bcl-2 expression in mycosis fungoides before and after PUVA therapy. Photodermatology, Photoimmunology & Photomedicine, 26(2), 107-9. https://doi.org/10.1111/j.1600-0781.2010.00496.x
Weshahy H, et al. Bcl-2 Expression in Mycosis Fungoides Before and After PUVA Therapy. Photodermatol Photoimmunol Photomed. 2010;26(2):107-9. PubMed PMID: 20415745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bcl-2 expression in mycosis fungoides before and after PUVA therapy. AU - Weshahy,Hani, AU - Mahgoub,Doa, AU - El-Eishy,Nermine, AU - El-Tawdy,Amira Mohamed, AU - Bassiouny,Dalia Ahmed, AU - Hunter,Nahla, AU - Hindawi,Ali, PY - 2010/4/27/entrez PY - 2010/4/27/pubmed PY - 2010/7/20/medline SP - 107 EP - 9 JF - Photodermatology, photoimmunology & photomedicine JO - Photodermatol Photoimmunol Photomed VL - 26 IS - 2 N2 - PUVA is the first therapeutic choice in early stages of mycosis fungoides (MF). In this study the effect of PUVA on bcl-2 expression in MF was assessed in 15 patients (three stage Ia and 12 stage Ib) and 10 controls. Two biopsies were taken from each patient before and after 24 sessions of PUVA therapy. Histopathological assessment and immunohistochemical staining for bcl-2 was performed and showed positive bcl-2 staining of lymphocytes in 53% of MF cases (8/15) before PUVA, with no statistically significant difference in the bcl-2 level before and after PUVA therapy (P value 0.3). A statistically significant difference was found in the bcl-2 level between control samples and MF patients' biopsies before (P value 0.02) and after PUVA therapy (P value 0.011). In conclusion, a lack of decline in the bcl-2 level and the absence of clinical or histopathological correlation with the bcl-2 level before and after PUVA therapy in MF patients suggest that PUVA-induced apoptosis in MF cases may occur through pathways other than bcl-2 inhibition. SN - 1600-0781 UR - https://www.unboundmedicine.com/medline/citation/20415745/Bcl_2_expression_in_mycosis_fungoides_before_and_after_PUVA_therapy_ L2 - https://doi.org/10.1111/j.1600-0781.2010.00496.x DB - PRIME DP - Unbound Medicine ER -