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[Expression and abscission of activated receptors and their ligands on/from NK cells in peripheral blood of patients with acute leukemia].
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Apr; 18(2):436-40.ZS

Abstract

This study was aimed to explore the immune escaping mechanisms based on expression and abscission of human natural killer (NK) cell activating receptors NKG2D and their ligands MICA/B, ULBP-1, 2, 3 in patients with acute leukemia (AL). 30 de novo AL patients and 10 healthy persons (control) were enrolled in study. Flow cytometry was used to detect the expression levels of MICA/B, ULBP-1, 2, 3 on leukemic cells. ELISA was used to detect the levels of soluble MICA (sMICA), solube MICB (sMICB) and soluble ULBP-1, -2, -3 in the serum. The results showed that sMICA, sMICB and ULBP-1, -2, -3 were not expressed or expressed at very low levels on leukemia cells of the patients; the levels of free sMICA and sMICB in serum of AL patients were higher than that in serum of healthy persons, there was significant difference (p<0.01). But the levels of ULBP 1-3 in serum of AL patients did not show obvious statistical difference as compared with healthy persons (p>0.05). It is concluded that the negative or low expression of NKG2D ligands (MICA, MICB and ULBPs) on surface of acute leukemia cells may lead to the immune escape of leukemia cells, the abscission of MICA and MICB, and the deficiency of ULBP expression on leukemia cells may be one of immune escape mechanisms of leukemia cells.

Authors+Show Affiliations

Graduate school, Anhui Medical University, and Department of Hematology, Provincial Hospital, Hefei 230001, Anhui Province, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

20416183

Citation

Fang, Xin-Chen, et al. "[Expression and Abscission of Activated Receptors and Their Ligands On/from NK Cells in Peripheral Blood of Patients With Acute Leukemia]." Zhongguo Shi Yan Xue Ye Xue Za Zhi, vol. 18, no. 2, 2010, pp. 436-40.
Fang XC, Liu HL, Sun ZM, et al. [Expression and abscission of activated receptors and their ligands on/from NK cells in peripheral blood of patients with acute leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010;18(2):436-40.
Fang, X. C., Liu, H. L., Sun, Z. M., Gui, L., Geng, L. Q., Wang, X. B., Zhou, M., & Wang, Z. Y. (2010). [Expression and abscission of activated receptors and their ligands on/from NK cells in peripheral blood of patients with acute leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 18(2), 436-40.
Fang XC, et al. [Expression and Abscission of Activated Receptors and Their Ligands On/from NK Cells in Peripheral Blood of Patients With Acute Leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010;18(2):436-40. PubMed PMID: 20416183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression and abscission of activated receptors and their ligands on/from NK cells in peripheral blood of patients with acute leukemia]. AU - Fang,Xin-Chen, AU - Liu,Hui-Lan, AU - Sun,Zi-Min, AU - Gui,Li, AU - Geng,Liang-Quan, AU - Wang,Xing-Bin, AU - Zhou,Miao, AU - Wang,Zu-Yi, PY - 2010/4/27/entrez PY - 2010/4/27/pubmed PY - 2011/10/1/medline SP - 436 EP - 40 JF - Zhongguo shi yan xue ye xue za zhi JO - Zhongguo Shi Yan Xue Ye Xue Za Zhi VL - 18 IS - 2 N2 - This study was aimed to explore the immune escaping mechanisms based on expression and abscission of human natural killer (NK) cell activating receptors NKG2D and their ligands MICA/B, ULBP-1, 2, 3 in patients with acute leukemia (AL). 30 de novo AL patients and 10 healthy persons (control) were enrolled in study. Flow cytometry was used to detect the expression levels of MICA/B, ULBP-1, 2, 3 on leukemic cells. ELISA was used to detect the levels of soluble MICA (sMICA), solube MICB (sMICB) and soluble ULBP-1, -2, -3 in the serum. The results showed that sMICA, sMICB and ULBP-1, -2, -3 were not expressed or expressed at very low levels on leukemia cells of the patients; the levels of free sMICA and sMICB in serum of AL patients were higher than that in serum of healthy persons, there was significant difference (p<0.01). But the levels of ULBP 1-3 in serum of AL patients did not show obvious statistical difference as compared with healthy persons (p>0.05). It is concluded that the negative or low expression of NKG2D ligands (MICA, MICB and ULBPs) on surface of acute leukemia cells may lead to the immune escape of leukemia cells, the abscission of MICA and MICB, and the deficiency of ULBP expression on leukemia cells may be one of immune escape mechanisms of leukemia cells. SN - 1009-2137 UR - https://www.unboundmedicine.com/medline/citation/20416183/[Expression_and_abscission_of_activated_receptors_and_their_ligands_on/from_NK_cells_in_peripheral_blood_of_patients_with_acute_leukemia]_ L2 - https://medlineplus.gov/leukemia.html DB - PRIME DP - Unbound Medicine ER -