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[Changes in urotensin-II expression in airway remodelling in asthmatic rats].
Zhongguo Dang Dai Er Ke Za Zhi. 2010 Apr; 12(4):287-9.ZD

Abstract

OBJECTIVE

To study the role of urotension-II in serum and bronchoalveolar lavage fluid (BALF) in the process of airway remodelling in asthmatic rats.

METHODS

Thirty-two male Sprague-Dawley (SD) rats were randomly divided into normal control and 2-week, 4-week and 8-week asthmatic groups (OVA inhalation of 2, 4 and 8 weeks respectively). Rats were sensitized and challenged by OVA to establish a model of asthma. The bronchial wall thickness and the airway smooth muscle thickness were measured by image analysis system. The urotension-II contents in serum and BALF were determined using ELISA.

RESULTS

The bronchial wall thickness and the airway smooth muscle thickness in the three asthmatic groups significantly increased compared with those in the normal control group (P<0.01). The urotension-II contents in serum and BALF in the three asthmatic groups also increased significantly compared with those in the normal control group (P<0.01). The urotension-II contents in serum and BALF in the 8-week asthmatic group were the highest, followed by the 4-week and the 2-week asthmatic groups (P<0.01). BALF urotension-II contents were positively correlated with the bronchial wall thickness and the airway smooth muscle thickness as well as serum U-II contents in the four groups.

CONCLUSIONS

The urotension-II contents in serum and BALF in the process of airway remodeling increase in asthmatic rats. The changes in serum and BALF urotension-II contents may be associated with airway remodeling in asthmatic rats.

Authors+Show Affiliations

Department of Respiratory Diseases, Yuying Children's Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325027, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

20416223

Citation

Liang, Ya-Feng, et al. "[Changes in urotensin-II Expression in Airway Remodelling in Asthmatic Rats]." Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, vol. 12, no. 4, 2010, pp. 287-9.
Liang YF, Zhang WX, Li CC, et al. [Changes in urotensin-II expression in airway remodelling in asthmatic rats]. Zhongguo Dang Dai Er Ke Za Zhi. 2010;12(4):287-9.
Liang, Y. F., Zhang, W. X., Li, C. C., Wang, X. M., & Ge, L. S. (2010). [Changes in urotensin-II expression in airway remodelling in asthmatic rats]. Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 12(4), 287-9.
Liang YF, et al. [Changes in urotensin-II Expression in Airway Remodelling in Asthmatic Rats]. Zhongguo Dang Dai Er Ke Za Zhi. 2010;12(4):287-9. PubMed PMID: 20416223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Changes in urotensin-II expression in airway remodelling in asthmatic rats]. AU - Liang,Ya-Feng, AU - Zhang,Wei-Xi, AU - Li,Chang-Chong, AU - Wang,Xiao-Ming, AU - Ge,Li-Sha, PY - 2010/4/27/entrez PY - 2010/4/27/pubmed PY - 2010/8/4/medline SP - 287 EP - 9 JF - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics JO - Zhongguo Dang Dai Er Ke Za Zhi VL - 12 IS - 4 N2 - OBJECTIVE: To study the role of urotension-II in serum and bronchoalveolar lavage fluid (BALF) in the process of airway remodelling in asthmatic rats. METHODS: Thirty-two male Sprague-Dawley (SD) rats were randomly divided into normal control and 2-week, 4-week and 8-week asthmatic groups (OVA inhalation of 2, 4 and 8 weeks respectively). Rats were sensitized and challenged by OVA to establish a model of asthma. The bronchial wall thickness and the airway smooth muscle thickness were measured by image analysis system. The urotension-II contents in serum and BALF were determined using ELISA. RESULTS: The bronchial wall thickness and the airway smooth muscle thickness in the three asthmatic groups significantly increased compared with those in the normal control group (P<0.01). The urotension-II contents in serum and BALF in the three asthmatic groups also increased significantly compared with those in the normal control group (P<0.01). The urotension-II contents in serum and BALF in the 8-week asthmatic group were the highest, followed by the 4-week and the 2-week asthmatic groups (P<0.01). BALF urotension-II contents were positively correlated with the bronchial wall thickness and the airway smooth muscle thickness as well as serum U-II contents in the four groups. CONCLUSIONS: The urotension-II contents in serum and BALF in the process of airway remodeling increase in asthmatic rats. The changes in serum and BALF urotension-II contents may be associated with airway remodeling in asthmatic rats. SN - 1008-8830 UR - https://www.unboundmedicine.com/medline/citation/20416223/[Changes_in_urotensin_II_expression_in_airway_remodelling_in_asthmatic_rats]_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -