Tags

Type your tag names separated by a space and hit enter

The effect of cranberry juice and cranberry proanthocyanidins on the infectivity of human enteric viral surrogates.
Food Microbiol. 2010 Jun; 27(4):535-40.FM

Abstract

The effect of cranberry juice (CJ) and cranberry proanthocyanidins (PAC) on the infectivity of human enteric virus surrogates, murine norovirus (MNV-1), feline calicivirus (FCV-F9), MS2(ssRNA) bacteriophage, and phiX-174(ssDNA) bacteriophage was studied. Viruses at high (approximately 7 log(10) PFU/ml) or low (approximately 5 log(10) PFU/ml) titers were mixed with equal volumes of CJ, 0.30, 0.60, and 1.20 mg/ml final PAC concentration, or water and incubated for 1 h at room temperature. Viral infectivity after treatments was evaluated using standardized plaque assays. At low viral titers, FCV-F9 was undetectable after exposure to CJ or the three tested PAC solutions. MNV-1 was reduced by 2.06 log(10) PFU/ml with CJ, and 2.63, 2.75, and 2.95 log(10) PFU/ml with 0.15, 0.30, and 0.60 mg/ml PAC, respectively. MS2 titers were reduced by 1.14 log(10) PFU/ml with CJ, and 0.55, 0.80, and 0.96 log(10) PFU/ml with 0.15, 0.30, and 0.60 mg/ml PAC, respectively. phi-X174 titers were reduced by 1.79 log(10) PFU/ml with CJ, and 1.95, 3.67, and 4.98 log(10) PFU/ml with PAC at 0.15, 0.30, and 0.60 mg/ml, respectively. Experiments using high titers showed similar trends but with decreased effects. CJ and PAC show promise as natural antivirals that could potentially be exploited for foodborne viral illness treatment and prevention.

Authors+Show Affiliations

Department of Food Science and Technology, University of Tennessee-Knoxville, Knoxville, TN 37996, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20417404

Citation

Su, Xiaowei, et al. "The Effect of Cranberry Juice and Cranberry Proanthocyanidins On the Infectivity of Human Enteric Viral Surrogates." Food Microbiology, vol. 27, no. 4, 2010, pp. 535-40.
Su X, Howell AB, D'Souza DH. The effect of cranberry juice and cranberry proanthocyanidins on the infectivity of human enteric viral surrogates. Food Microbiol. 2010;27(4):535-40.
Su, X., Howell, A. B., & D'Souza, D. H. (2010). The effect of cranberry juice and cranberry proanthocyanidins on the infectivity of human enteric viral surrogates. Food Microbiology, 27(4), 535-40. https://doi.org/10.1016/j.fm.2010.01.001
Su X, Howell AB, D'Souza DH. The Effect of Cranberry Juice and Cranberry Proanthocyanidins On the Infectivity of Human Enteric Viral Surrogates. Food Microbiol. 2010;27(4):535-40. PubMed PMID: 20417404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of cranberry juice and cranberry proanthocyanidins on the infectivity of human enteric viral surrogates. AU - Su,Xiaowei, AU - Howell,Amy B, AU - D'Souza,Doris H, Y1 - 2010/01/25/ PY - 2009/10/02/received PY - 2010/01/10/revised PY - 2010/01/17/accepted PY - 2010/4/27/entrez PY - 2010/4/27/pubmed PY - 2010/7/16/medline SP - 535 EP - 40 JF - Food microbiology JO - Food Microbiol. VL - 27 IS - 4 N2 - The effect of cranberry juice (CJ) and cranberry proanthocyanidins (PAC) on the infectivity of human enteric virus surrogates, murine norovirus (MNV-1), feline calicivirus (FCV-F9), MS2(ssRNA) bacteriophage, and phiX-174(ssDNA) bacteriophage was studied. Viruses at high (approximately 7 log(10) PFU/ml) or low (approximately 5 log(10) PFU/ml) titers were mixed with equal volumes of CJ, 0.30, 0.60, and 1.20 mg/ml final PAC concentration, or water and incubated for 1 h at room temperature. Viral infectivity after treatments was evaluated using standardized plaque assays. At low viral titers, FCV-F9 was undetectable after exposure to CJ or the three tested PAC solutions. MNV-1 was reduced by 2.06 log(10) PFU/ml with CJ, and 2.63, 2.75, and 2.95 log(10) PFU/ml with 0.15, 0.30, and 0.60 mg/ml PAC, respectively. MS2 titers were reduced by 1.14 log(10) PFU/ml with CJ, and 0.55, 0.80, and 0.96 log(10) PFU/ml with 0.15, 0.30, and 0.60 mg/ml PAC, respectively. phi-X174 titers were reduced by 1.79 log(10) PFU/ml with CJ, and 1.95, 3.67, and 4.98 log(10) PFU/ml with PAC at 0.15, 0.30, and 0.60 mg/ml, respectively. Experiments using high titers showed similar trends but with decreased effects. CJ and PAC show promise as natural antivirals that could potentially be exploited for foodborne viral illness treatment and prevention. SN - 1095-9998 UR - https://www.unboundmedicine.com/medline/citation/20417404/The_effect_of_cranberry_juice_and_cranberry_proanthocyanidins_on_the_infectivity_of_human_enteric_viral_surrogates_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0740-0020(10)00015-8 DB - PRIME DP - Unbound Medicine ER -