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Body height and risk of venous thromboembolism: The Tromsø Study.
Am J Epidemiol 2010; 171(10):1109-15AJ

Abstract

An association between body height and venous thromboembolism (VTE) has been suggested by previous studies including males only. The aim of this prospective cohort study was to investigate the sex-specific impact of body height on risk of VTE in a general population. Risk factors, including body height and weight, were registered for 26,727 subjects aged 25-96 years who participated in the Tromsø Study (Norway) in 1994-1995. Incident VTE events were registered through September 1, 2007. There were 462 VTE events during a median 12.5 years of follow-up. Body height was a risk factor for VTE in men, but not in women. Multivariable hazard ratios per 10 cm, adjusted for age, body mass index, diabetes, smoking, and hormone therapy (women), were 1.34 (95% confidence interval: 1.09, 1.64) for men and 1.13 (95% confidence interval: 0.91, 1.40) for women. Hazard ratios by quartiles of body height revealed that men in the upper quartile (>181 cm) had a 1.99-fold (95% confidence interval: 1.35, 2.92) increased risk of VTE compared with men in the lowest quartile (<173 cm) (P for trend across quartiles = 0.002). There was no significant trend (P = 0.2) across quartiles of body height for women. Study findings revealed that body height is a sex-specific risk factor for VTE in men.

Authors+Show Affiliations

Department of Medicine, Institute of Clinical Medicine, University of Tromsø, Norway. sigrid.brakkan@uit.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20418276

Citation

Braekkan, Sigrid K., et al. "Body Height and Risk of Venous Thromboembolism: the Tromsø Study." American Journal of Epidemiology, vol. 171, no. 10, 2010, pp. 1109-15.
Braekkan SK, Borch KH, Mathiesen EB, et al. Body height and risk of venous thromboembolism: The Tromsø Study. Am J Epidemiol. 2010;171(10):1109-15.
Braekkan, S. K., Borch, K. H., Mathiesen, E. B., Njølstad, I., Wilsgaard, T., & Hansen, J. B. (2010). Body height and risk of venous thromboembolism: The Tromsø Study. American Journal of Epidemiology, 171(10), pp. 1109-15. doi:10.1093/aje/kwq066.
Braekkan SK, et al. Body Height and Risk of Venous Thromboembolism: the Tromsø Study. Am J Epidemiol. 2010 May 15;171(10):1109-15. PubMed PMID: 20418276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body height and risk of venous thromboembolism: The Tromsø Study. AU - Braekkan,Sigrid K, AU - Borch,Knut H, AU - Mathiesen,Ellisiv B, AU - Njølstad,Inger, AU - Wilsgaard,Tom, AU - Hansen,John-Bjarne, Y1 - 2010/04/23/ PY - 2010/4/27/entrez PY - 2010/4/27/pubmed PY - 2010/5/28/medline SP - 1109 EP - 15 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 171 IS - 10 N2 - An association between body height and venous thromboembolism (VTE) has been suggested by previous studies including males only. The aim of this prospective cohort study was to investigate the sex-specific impact of body height on risk of VTE in a general population. Risk factors, including body height and weight, were registered for 26,727 subjects aged 25-96 years who participated in the Tromsø Study (Norway) in 1994-1995. Incident VTE events were registered through September 1, 2007. There were 462 VTE events during a median 12.5 years of follow-up. Body height was a risk factor for VTE in men, but not in women. Multivariable hazard ratios per 10 cm, adjusted for age, body mass index, diabetes, smoking, and hormone therapy (women), were 1.34 (95% confidence interval: 1.09, 1.64) for men and 1.13 (95% confidence interval: 0.91, 1.40) for women. Hazard ratios by quartiles of body height revealed that men in the upper quartile (>181 cm) had a 1.99-fold (95% confidence interval: 1.35, 2.92) increased risk of VTE compared with men in the lowest quartile (<173 cm) (P for trend across quartiles = 0.002). There was no significant trend (P = 0.2) across quartiles of body height for women. Study findings revealed that body height is a sex-specific risk factor for VTE in men. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/20418276/Body_height_and_risk_of_venous_thromboembolism:_The_Tromsø_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwq066 DB - PRIME DP - Unbound Medicine ER -