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Body height and risk of venous thromboembolism: The Tromsø Study.

Abstract

An association between body height and venous thromboembolism (VTE) has been suggested by previous studies including males only. The aim of this prospective cohort study was to investigate the sex-specific impact of body height on risk of VTE in a general population. Risk factors, including body height and weight, were registered for 26,727 subjects aged 25-96 years who participated in the Tromsø Study (Norway) in 1994-1995. Incident VTE events were registered through September 1, 2007. There were 462 VTE events during a median 12.5 years of follow-up. Body height was a risk factor for VTE in men, but not in women. Multivariable hazard ratios per 10 cm, adjusted for age, body mass index, diabetes, smoking, and hormone therapy (women), were 1.34 (95% confidence interval: 1.09, 1.64) for men and 1.13 (95% confidence interval: 0.91, 1.40) for women. Hazard ratios by quartiles of body height revealed that men in the upper quartile (>181 cm) had a 1.99-fold (95% confidence interval: 1.35, 2.92) increased risk of VTE compared with men in the lowest quartile (<173 cm) (P for trend across quartiles = 0.002). There was no significant trend (P = 0.2) across quartiles of body height for women. Study findings revealed that body height is a sex-specific risk factor for VTE in men.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Institute of Clinical Medicine, University of Tromsø, Norway. sigrid.brakkan@uit.no

    , , , ,

    Source

    American journal of epidemiology 171:10 2010 May 15 pg 1109-15

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Body Height
    Confidence Intervals
    Female
    Health Surveys
    Humans
    Incidence
    Male
    Middle Aged
    Multivariate Analysis
    Norway
    Poisson Distribution
    Proportional Hazards Models
    Prospective Studies
    Registries
    Risk Assessment
    Risk Factors
    Sex Factors
    Surveys and Questionnaires
    Venous Thromboembolism

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20418276

    Citation

    Braekkan, Sigrid K., et al. "Body Height and Risk of Venous Thromboembolism: the Tromsø Study." American Journal of Epidemiology, vol. 171, no. 10, 2010, pp. 1109-15.
    Braekkan SK, Borch KH, Mathiesen EB, et al. Body height and risk of venous thromboembolism: The Tromsø Study. Am J Epidemiol. 2010;171(10):1109-15.
    Braekkan, S. K., Borch, K. H., Mathiesen, E. B., Njølstad, I., Wilsgaard, T., & Hansen, J. B. (2010). Body height and risk of venous thromboembolism: The Tromsø Study. American Journal of Epidemiology, 171(10), pp. 1109-15. doi:10.1093/aje/kwq066.
    Braekkan SK, et al. Body Height and Risk of Venous Thromboembolism: the Tromsø Study. Am J Epidemiol. 2010 May 15;171(10):1109-15. PubMed PMID: 20418276.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Body height and risk of venous thromboembolism: The Tromsø Study. AU - Braekkan,Sigrid K, AU - Borch,Knut H, AU - Mathiesen,Ellisiv B, AU - Njølstad,Inger, AU - Wilsgaard,Tom, AU - Hansen,John-Bjarne, Y1 - 2010/04/23/ PY - 2010/4/27/entrez PY - 2010/4/27/pubmed PY - 2010/5/28/medline SP - 1109 EP - 15 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 171 IS - 10 N2 - An association between body height and venous thromboembolism (VTE) has been suggested by previous studies including males only. The aim of this prospective cohort study was to investigate the sex-specific impact of body height on risk of VTE in a general population. Risk factors, including body height and weight, were registered for 26,727 subjects aged 25-96 years who participated in the Tromsø Study (Norway) in 1994-1995. Incident VTE events were registered through September 1, 2007. There were 462 VTE events during a median 12.5 years of follow-up. Body height was a risk factor for VTE in men, but not in women. Multivariable hazard ratios per 10 cm, adjusted for age, body mass index, diabetes, smoking, and hormone therapy (women), were 1.34 (95% confidence interval: 1.09, 1.64) for men and 1.13 (95% confidence interval: 0.91, 1.40) for women. Hazard ratios by quartiles of body height revealed that men in the upper quartile (>181 cm) had a 1.99-fold (95% confidence interval: 1.35, 2.92) increased risk of VTE compared with men in the lowest quartile (<173 cm) (P for trend across quartiles = 0.002). There was no significant trend (P = 0.2) across quartiles of body height for women. Study findings revealed that body height is a sex-specific risk factor for VTE in men. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/20418276/Body_height_and_risk_of_venous_thromboembolism:_The_Tromsø_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwq066 DB - PRIME DP - Unbound Medicine ER -