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Inverse relationship between cerebrovascular lesions and severity of lewy body pathology in patients with lewy body diseases.
J Neuropathol Exp Neurol. 2010 May; 69(5):442-8.JN

Abstract

Cerebrovascular pathology is a major cause of stroke and mortality. Studies on prevalence of cerebrovascular pathologies in dementia with Lewy bodies (DLBs) and Parkinson disease (PD) patients are scarce and contradictory. We aimed to determine the prevalence and severity of cerebrovascular pathologies in DLB and PD and to analyze their relationship to LB pathology. The prevalence and severity of atherosclerosis in the circle of Willis, cerebral amyloid angiopathy, cerebral infarcts, hemorrhages, small-vessel disease, white matter lesions, including the Consortium to Establish a Registry for Alzheimer Disease (CERAD) protocol as well as Braak neurofibrillary tangle stages for AD pathology were analyzed in autopsy-verified DLB (n = 13), PD (n = 102), and control subjects (n = 53). In all patient groups, the extent of LB pathology was inversely correlated to the severity of most vascular pathologies (atherosclerosis, infarcts, and small-vessel disease; all p < 0.05). By contrast, cerebral amyloid angiopathy, CERAD, and Braak neurofibrillary tangle stages were positively correlated with LB pathology (p < 0.05). Whereas the overall prevalence and severity of small-vessel disease, infarcts, hemorrhages, and white matter lesions were comparable among both disease groups, the extents of atherosclerosis, cerebral amyloid angiopathy, CERAD, and Braak neurofibrillary tangle stages were significantly higher in DLB than in those of PD patients (p < 0.05). Microinfarcts were statistically more prevalent in each patient group than in controls, whereas gross infarcts predominated in controls (p < 0.05 each). In conclusion, DLB and PD patients with advanced LB pathology were less likely to show severe cerebrovascular disease or history of stroke.

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Authors+Show Affiliations

Ghebremedhin E
Institute for Clinical Neuroanatomy, J.W. Goethe-University, Frankfurt/Main, Germany. e.ghebremedhin@uq.edu.au
Rosenberger A
No affiliation info available
Rüb U
No affiliation info available
Vuksic M
No affiliation info available
Berhe T
No affiliation info available
Bickeböller H
No affiliation info available
de Vos RA
No affiliation info available
Thal DR
No affiliation info available
Deller T
No affiliation info available

MeSH

AgedAged, 80 and overAmyloid beta-PeptidesBrain InfarctionCase-Control StudiesCerebral AngiographyCerebrovascular DisordersChi-Square DistributionCircle of WillisFemaleHemorrhageHumansLewy BodiesLewy Body DiseaseMaleMiddle AgedNeurofibrillary TanglesNeurologic ExaminationParkinson DiseasePrincipal Component AnalysisRetrospective Studies

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20418782

Citation

Ghebremedhin, Estifanos, et al. "Inverse Relationship Between Cerebrovascular Lesions and Severity of Lewy Body Pathology in Patients With Lewy Body Diseases." Journal of Neuropathology and Experimental Neurology, vol. 69, no. 5, 2010, pp. 442-8.
Ghebremedhin E, Rosenberger A, Rüb U, et al. Inverse relationship between cerebrovascular lesions and severity of lewy body pathology in patients with lewy body diseases. J Neuropathol Exp Neurol. 2010;69(5):442-8.
Ghebremedhin, E., Rosenberger, A., Rüb, U., Vuksic, M., Berhe, T., Bickeböller, H., de Vos, R. A., Thal, D. R., & Deller, T. (2010). Inverse relationship between cerebrovascular lesions and severity of lewy body pathology in patients with lewy body diseases. Journal of Neuropathology and Experimental Neurology, 69(5), 442-8. https://doi.org/10.1097/NEN.0b013e3181d88e63
Ghebremedhin E, et al. Inverse Relationship Between Cerebrovascular Lesions and Severity of Lewy Body Pathology in Patients With Lewy Body Diseases. J Neuropathol Exp Neurol. 2010;69(5):442-8. PubMed PMID: 20418782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inverse relationship between cerebrovascular lesions and severity of lewy body pathology in patients with lewy body diseases. AU - Ghebremedhin,Estifanos, AU - Rosenberger,Albert, AU - Rüb,Udo, AU - Vuksic,Mario, AU - Berhe,Tzeggai, AU - Bickeböller,Heike, AU - de Vos,Rob A I, AU - Thal,Dietmar R, AU - Deller,Thomas, PY - 2010/4/27/entrez PY - 2010/4/27/pubmed PY - 2010/5/15/medline SP - 442 EP - 8 JF - Journal of neuropathology and experimental neurology JO - J Neuropathol Exp Neurol VL - 69 IS - 5 N2 - Cerebrovascular pathology is a major cause of stroke and mortality. Studies on prevalence of cerebrovascular pathologies in dementia with Lewy bodies (DLBs) and Parkinson disease (PD) patients are scarce and contradictory. We aimed to determine the prevalence and severity of cerebrovascular pathologies in DLB and PD and to analyze their relationship to LB pathology. The prevalence and severity of atherosclerosis in the circle of Willis, cerebral amyloid angiopathy, cerebral infarcts, hemorrhages, small-vessel disease, white matter lesions, including the Consortium to Establish a Registry for Alzheimer Disease (CERAD) protocol as well as Braak neurofibrillary tangle stages for AD pathology were analyzed in autopsy-verified DLB (n = 13), PD (n = 102), and control subjects (n = 53). In all patient groups, the extent of LB pathology was inversely correlated to the severity of most vascular pathologies (atherosclerosis, infarcts, and small-vessel disease; all p < 0.05). By contrast, cerebral amyloid angiopathy, CERAD, and Braak neurofibrillary tangle stages were positively correlated with LB pathology (p < 0.05). Whereas the overall prevalence and severity of small-vessel disease, infarcts, hemorrhages, and white matter lesions were comparable among both disease groups, the extents of atherosclerosis, cerebral amyloid angiopathy, CERAD, and Braak neurofibrillary tangle stages were significantly higher in DLB than in those of PD patients (p < 0.05). Microinfarcts were statistically more prevalent in each patient group than in controls, whereas gross infarcts predominated in controls (p < 0.05 each). In conclusion, DLB and PD patients with advanced LB pathology were less likely to show severe cerebrovascular disease or history of stroke. SN - 1554-6578 UR - https://www.unboundmedicine.com/medline/citation/20418782/Inverse_relationship_between_cerebrovascular_lesions_and_severity_of_lewy_body_pathology_in_patients_with_lewy_body_diseases_ L2 - https://academic.oup.com/jnen/article-lookup/doi/10.1097/NEN.0b013e3181d88e63 DB - PRIME DP - Unbound Medicine ER -