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Transient receptor potential channels as novel drug targets in respiratory diseases.
Curr Opin Investig Drugs. 2010 May; 11(5):535-42.CO

Abstract

A subpopulation of nociceptive primary sensory neurons expresses six different transient receptor potential (TRP) ion channels of the vanilloid (V1, V2, V3 and V4), melastatin (M8) and ankyrin (A1) subtypes. TRPV1 mediates the tussive action of capsaicin, which is widely used in cough provocation studies. The upregulation of TRPV1 expression and function has been reported in asthma and other inflammatory conditions. TRPA1 is targeted by a series of byproducts of oxidative and nitrative stress, including acrolein, 4-hydroxy-2-nonenal and hydrogen peroxide. Proinflammatory neuropeptides are released from nociceptive nerve terminals after TRPV1/TRPA1 stimulation, thereby causing airway neurogenic inflammation. In addition, the early inflammatory response to cigarette smoke is mediated entirely by neuronal TRPA1. TRPV1 and TRPA1 antagonists may therefore represent potential antitussive and anti-inflammatory therapeutics for respiratory airway diseases.

Authors+Show Affiliations

University of Florence, Department of Preclinical and Clinical Pharmacology, Viale Pieraccini 6, 50139, Florence, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20419599

Citation

Nassini, Romina, et al. "Transient Receptor Potential Channels as Novel Drug Targets in Respiratory Diseases." Current Opinion in Investigational Drugs (London, England : 2000), vol. 11, no. 5, 2010, pp. 535-42.
Nassini R, Materazzi S, De Siena G, et al. Transient receptor potential channels as novel drug targets in respiratory diseases. Curr Opin Investig Drugs. 2010;11(5):535-42.
Nassini, R., Materazzi, S., De Siena, G., De Cesaris, F., & Geppetti, P. (2010). Transient receptor potential channels as novel drug targets in respiratory diseases. Current Opinion in Investigational Drugs (London, England : 2000), 11(5), 535-42.
Nassini R, et al. Transient Receptor Potential Channels as Novel Drug Targets in Respiratory Diseases. Curr Opin Investig Drugs. 2010;11(5):535-42. PubMed PMID: 20419599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transient receptor potential channels as novel drug targets in respiratory diseases. AU - Nassini,Romina, AU - Materazzi,Serena, AU - De Siena,Gaetano, AU - De Cesaris,Francesco, AU - Geppetti,Pierangelo, PY - 2010/4/27/entrez PY - 2010/4/27/pubmed PY - 2010/7/28/medline SP - 535 EP - 42 JF - Current opinion in investigational drugs (London, England : 2000) JO - Curr Opin Investig Drugs VL - 11 IS - 5 N2 - A subpopulation of nociceptive primary sensory neurons expresses six different transient receptor potential (TRP) ion channels of the vanilloid (V1, V2, V3 and V4), melastatin (M8) and ankyrin (A1) subtypes. TRPV1 mediates the tussive action of capsaicin, which is widely used in cough provocation studies. The upregulation of TRPV1 expression and function has been reported in asthma and other inflammatory conditions. TRPA1 is targeted by a series of byproducts of oxidative and nitrative stress, including acrolein, 4-hydroxy-2-nonenal and hydrogen peroxide. Proinflammatory neuropeptides are released from nociceptive nerve terminals after TRPV1/TRPA1 stimulation, thereby causing airway neurogenic inflammation. In addition, the early inflammatory response to cigarette smoke is mediated entirely by neuronal TRPA1. TRPV1 and TRPA1 antagonists may therefore represent potential antitussive and anti-inflammatory therapeutics for respiratory airway diseases. SN - 2040-3429 UR - https://www.unboundmedicine.com/medline/citation/20419599/Transient_receptor_potential_channels_as_novel_drug_targets_in_respiratory_diseases_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:20419599 DB - PRIME DP - Unbound Medicine ER -