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Oxidative stress and Alzheimer's disease: dietary polyphenols as potential therapeutic agents.
Expert Rev Neurother. 2010 May; 10(5):729-45.ER

Abstract

Oxidative stress has been strongly implicated in the pathophysiology of neurodegenerative disorders such as Alzheimer's disease (AD). In recent years, antioxidants - especially those of dietary origin - have been suggested as possible agents useful for the prevention and treatment of AD. This article reviews the role of oxidative stress and the contribution of free radicals in the development of AD, and also discusses the use of antioxidants as a therapeutic strategy in the amelioration of this illness. The antioxidant potential of polyphenolic compounds obtained from dietary sources, such as anthocyanins from berries, catechins and theaflavins from tea, curcumin from turmeric, resveratrol from grapes and peanuts, the dihydrochalcones aspalathin and nothofagin from rooibos and the xanthone mangiferin from honeybush, are discussed in this review. The neuroprotective effects of these phytochemicals in preclinical models of AD are highlighted. Finally, innovative concepts, novel hypotheses, current challenges and future directions in the use of dietary polyphenols for the treatment of AD are discussed.

Authors+Show Affiliations

Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH 44272, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20420493

Citation

Darvesh, Altaf S., et al. "Oxidative Stress and Alzheimer's Disease: Dietary Polyphenols as Potential Therapeutic Agents." Expert Review of Neurotherapeutics, vol. 10, no. 5, 2010, pp. 729-45.
Darvesh AS, Carroll RT, Bishayee A, et al. Oxidative stress and Alzheimer's disease: dietary polyphenols as potential therapeutic agents. Expert Rev Neurother. 2010;10(5):729-45.
Darvesh, A. S., Carroll, R. T., Bishayee, A., Geldenhuys, W. J., & Van der Schyf, C. J. (2010). Oxidative stress and Alzheimer's disease: dietary polyphenols as potential therapeutic agents. Expert Review of Neurotherapeutics, 10(5), 729-45. https://doi.org/10.1586/ern.10.42
Darvesh AS, et al. Oxidative Stress and Alzheimer's Disease: Dietary Polyphenols as Potential Therapeutic Agents. Expert Rev Neurother. 2010;10(5):729-45. PubMed PMID: 20420493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress and Alzheimer's disease: dietary polyphenols as potential therapeutic agents. AU - Darvesh,Altaf S, AU - Carroll,Richard T, AU - Bishayee,Anupam, AU - Geldenhuys,Werner J, AU - Van der Schyf,Cornelis J, PY - 2010/4/28/entrez PY - 2010/4/28/pubmed PY - 2010/8/12/medline SP - 729 EP - 45 JF - Expert review of neurotherapeutics JO - Expert Rev Neurother VL - 10 IS - 5 N2 - Oxidative stress has been strongly implicated in the pathophysiology of neurodegenerative disorders such as Alzheimer's disease (AD). In recent years, antioxidants - especially those of dietary origin - have been suggested as possible agents useful for the prevention and treatment of AD. This article reviews the role of oxidative stress and the contribution of free radicals in the development of AD, and also discusses the use of antioxidants as a therapeutic strategy in the amelioration of this illness. The antioxidant potential of polyphenolic compounds obtained from dietary sources, such as anthocyanins from berries, catechins and theaflavins from tea, curcumin from turmeric, resveratrol from grapes and peanuts, the dihydrochalcones aspalathin and nothofagin from rooibos and the xanthone mangiferin from honeybush, are discussed in this review. The neuroprotective effects of these phytochemicals in preclinical models of AD are highlighted. Finally, innovative concepts, novel hypotheses, current challenges and future directions in the use of dietary polyphenols for the treatment of AD are discussed. SN - 1744-8360 UR - https://www.unboundmedicine.com/medline/citation/20420493/Oxidative_stress_and_Alzheimer's_disease:_dietary_polyphenols_as_potential_therapeutic_agents_ L2 - https://www.tandfonline.com/doi/full/10.1586/ern.10.42 DB - PRIME DP - Unbound Medicine ER -