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The changing epidemiology of invasive pneumococcal disease in aboriginal and non-aboriginal western Australians from 1997 through 2007 and emergence of nonvaccine serotypes.
Clin Infect Dis. 2010 Jun 01; 50(11):1477-86.CI

Abstract

BACKGROUND

. In 2001, Australia introduced a unique 7-valent pneumococcal conjugate vaccine (7vPCV) 2-, 4-, and 6-month schedule with a 23-valent pneumococcal polysaccharide vaccine (23vPPV) booster for Aboriginal children, and in 2005, 7vPCV alone in a 2-, 4-, and 6-month schedule for non-Aboriginal children. Aboriginal adults are offered 23vPPV but coverage is poor. We investigated trends in invasive pneumococcal disease (IPD) in Western Australia (WA).

METHODS.

Enhanced IPD surveillance has been ongoing since 1996. We calculated IPD incidence rates for Aboriginal and non-Aboriginal Australians before and after introduction of 7vPCV.

RESULTS.

A total of 1792 cases occurred during the period 1997-2007; the IPD incidence rate was 47 cases per 100,000 population per year among Aboriginal people and 7 cases per 100,000 population per year in non-Aboriginal people. After introduction of 7vPCV, IPD rates among Aboriginal children decreased by 46% for those <2 years of age and by 40% for those 2-4 years of age; rates decreased by 64% and 51% in equivalent age groups for non-Aboriginal children. IPD rates decreased by >30% in non-Aboriginal people 50 years of age but increased among Aboriginal adults (eg, from 59.1 to 109.6 cases per 100,000 population per year among those 30-49 years of age). Although IPD due to 7vPCV serotypes decreased in all age groups, IPD incidence due to non-7vPCV serotypes increased, and it almost doubled among Aboriginal adults 30-49 years of age (from 48.3 to 97.0 cases per 100,000 population per year). Among non-Aboriginal children, 37% of IPD is now due to serotype 19A.

CONCLUSIONS.

IPD incidence rates have decreased markedly among children and non-Aboriginal adults with a 3-dose infant 7vPCV schedule. However, IPD due to non-7vPCV serotypes has increased and is of particular concern among young Aboriginal adults, for whom an intensive 23vPPV campaign is needed. An immunization register covering all age groups should be established.

Authors+Show Affiliations

Telethon Institute for Child Health Research, Centre for Child Health Research, Queensland, Australia. deborahl@ichr.uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20420501

Citation

Lehmann, Deborah, et al. "The Changing Epidemiology of Invasive Pneumococcal Disease in Aboriginal and Non-aboriginal Western Australians From 1997 Through 2007 and Emergence of Nonvaccine Serotypes." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 50, no. 11, 2010, pp. 1477-86.
Lehmann D, Willis J, Moore HC, et al. The changing epidemiology of invasive pneumococcal disease in aboriginal and non-aboriginal western Australians from 1997 through 2007 and emergence of nonvaccine serotypes. Clin Infect Dis. 2010;50(11):1477-86.
Lehmann, D., Willis, J., Moore, H. C., Giele, C., Murphy, D., Keil, A. D., Harrison, C., Bayley, K., Watson, M., & Richmond, P. (2010). The changing epidemiology of invasive pneumococcal disease in aboriginal and non-aboriginal western Australians from 1997 through 2007 and emergence of nonvaccine serotypes. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 50(11), 1477-86. https://doi.org/10.1086/652440
Lehmann D, et al. The Changing Epidemiology of Invasive Pneumococcal Disease in Aboriginal and Non-aboriginal Western Australians From 1997 Through 2007 and Emergence of Nonvaccine Serotypes. Clin Infect Dis. 2010 Jun 1;50(11):1477-86. PubMed PMID: 20420501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The changing epidemiology of invasive pneumococcal disease in aboriginal and non-aboriginal western Australians from 1997 through 2007 and emergence of nonvaccine serotypes. AU - Lehmann,Deborah, AU - Willis,Judith, AU - Moore,Hannah C, AU - Giele,Carolien, AU - Murphy,Denise, AU - Keil,Anthony D, AU - Harrison,Catherine, AU - Bayley,Kathy, AU - Watson,Michael, AU - Richmond,Peter, PY - 2010/4/28/entrez PY - 2010/4/28/pubmed PY - 2010/7/20/medline SP - 1477 EP - 86 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 50 IS - 11 N2 - BACKGROUND. In 2001, Australia introduced a unique 7-valent pneumococcal conjugate vaccine (7vPCV) 2-, 4-, and 6-month schedule with a 23-valent pneumococcal polysaccharide vaccine (23vPPV) booster for Aboriginal children, and in 2005, 7vPCV alone in a 2-, 4-, and 6-month schedule for non-Aboriginal children. Aboriginal adults are offered 23vPPV but coverage is poor. We investigated trends in invasive pneumococcal disease (IPD) in Western Australia (WA). METHODS. Enhanced IPD surveillance has been ongoing since 1996. We calculated IPD incidence rates for Aboriginal and non-Aboriginal Australians before and after introduction of 7vPCV. RESULTS. A total of 1792 cases occurred during the period 1997-2007; the IPD incidence rate was 47 cases per 100,000 population per year among Aboriginal people and 7 cases per 100,000 population per year in non-Aboriginal people. After introduction of 7vPCV, IPD rates among Aboriginal children decreased by 46% for those <2 years of age and by 40% for those 2-4 years of age; rates decreased by 64% and 51% in equivalent age groups for non-Aboriginal children. IPD rates decreased by >30% in non-Aboriginal people 50 years of age but increased among Aboriginal adults (eg, from 59.1 to 109.6 cases per 100,000 population per year among those 30-49 years of age). Although IPD due to 7vPCV serotypes decreased in all age groups, IPD incidence due to non-7vPCV serotypes increased, and it almost doubled among Aboriginal adults 30-49 years of age (from 48.3 to 97.0 cases per 100,000 population per year). Among non-Aboriginal children, 37% of IPD is now due to serotype 19A. CONCLUSIONS. IPD incidence rates have decreased markedly among children and non-Aboriginal adults with a 3-dose infant 7vPCV schedule. However, IPD due to non-7vPCV serotypes has increased and is of particular concern among young Aboriginal adults, for whom an intensive 23vPPV campaign is needed. An immunization register covering all age groups should be established. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/20420501/The_changing_epidemiology_of_invasive_pneumococcal_disease_in_aboriginal_and_non_aboriginal_western_Australians_from_1997_through_2007_and_emergence_of_nonvaccine_serotypes_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/652440 DB - PRIME DP - Unbound Medicine ER -