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Fatalities associated with the 2009 H1N1 influenza A virus in New York city.
Clin Infect Dis. 2010 Jun 01; 50(11):1498-504.CI

Abstract

BACKGROUND

. When the 2009 H1N1 influenza A virus emerged in the United States, epidemiologic and clinical information about severe and fatal cases was limited. We report the first 47 fatal cases of 2009 H1N1 influenza in New York City.

METHODS.

The New York City Department of Health and Mental Hygiene conducted enhanced surveillance for hospitalizations and deaths associated with 2009 H1N1 influenza A virus. We collected basic demographic and clinical information for all patients who died and compared abstracted data from medical records for a sample of hospitalized patients who died and hospitalized patients who survived.

RESULTS.

From 24 April through 1 July 2009, 47 confirmed fatal cases of 2009 H1N1 influenza were reported to the New York City Department of Health and Mental Hygiene. Most decedents (60%) were ages 18-49 years, and only 4% were aged 65 years. Many (79%) had underlying risk conditions for severe seasonal influenza, and 58% were obese according to their body mass index. Thirteen (28%) had evidence of invasive bacterial coinfection. Approximately 50% of the decedents had developed acute respiratory distress syndrome. Among all hospitalized patients, decedents had presented for hospitalization later (median, 3 vs 2 days after illness onset; P < .05) and received oseltamivir later (median, 6.5 vs 3 days; P < .01) than surviving patients. Hospitalized patients who died were less likely to have received oseltamivir within 2 days of hospitalization than hospitalized patients who survived (61% vs 96%; P < .01).

CONCLUSIONS.

With community-wide transmission of 2009 H1N1 influenza A virus, timely medical care and antiviral therapy should be considered for patients with severe influenza-like illness or with underlying risk conditions for complications from influenza.

Authors+Show Affiliations

Bureau of Communicable Disease, Division of Disease Control, New York City Department of Health and Mental Hygiene, New York, USA. ELEE4@health.nyc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20420514

Citation

Lee, Ellen H., et al. "Fatalities Associated With the 2009 H1N1 Influenza a Virus in New York City." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 50, no. 11, 2010, pp. 1498-504.
Lee EH, Wu C, Lee EU, et al. Fatalities associated with the 2009 H1N1 influenza A virus in New York city. Clin Infect Dis. 2010;50(11):1498-504.
Lee, E. H., Wu, C., Lee, E. U., Stoute, A., Hanson, H., Cook, H. A., Nivin, B., Fine, A. D., Kerker, B. D., Harper, S. A., Layton, M. C., & Balter, S. (2010). Fatalities associated with the 2009 H1N1 influenza A virus in New York city. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 50(11), 1498-504. https://doi.org/10.1086/652446
Lee EH, et al. Fatalities Associated With the 2009 H1N1 Influenza a Virus in New York City. Clin Infect Dis. 2010 Jun 1;50(11):1498-504. PubMed PMID: 20420514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatalities associated with the 2009 H1N1 influenza A virus in New York city. AU - Lee,Ellen H, AU - Wu,Charles, AU - Lee,Elsie U, AU - Stoute,Alaina, AU - Hanson,Heather, AU - Cook,Heather A, AU - Nivin,Beth, AU - Fine,Annie D, AU - Kerker,Bonnie D, AU - Harper,Scott A, AU - Layton,Marcelle C, AU - Balter,Sharon, PY - 2010/4/28/entrez PY - 2010/4/28/pubmed PY - 2010/7/20/medline SP - 1498 EP - 504 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 50 IS - 11 N2 - BACKGROUND. When the 2009 H1N1 influenza A virus emerged in the United States, epidemiologic and clinical information about severe and fatal cases was limited. We report the first 47 fatal cases of 2009 H1N1 influenza in New York City. METHODS. The New York City Department of Health and Mental Hygiene conducted enhanced surveillance for hospitalizations and deaths associated with 2009 H1N1 influenza A virus. We collected basic demographic and clinical information for all patients who died and compared abstracted data from medical records for a sample of hospitalized patients who died and hospitalized patients who survived. RESULTS. From 24 April through 1 July 2009, 47 confirmed fatal cases of 2009 H1N1 influenza were reported to the New York City Department of Health and Mental Hygiene. Most decedents (60%) were ages 18-49 years, and only 4% were aged 65 years. Many (79%) had underlying risk conditions for severe seasonal influenza, and 58% were obese according to their body mass index. Thirteen (28%) had evidence of invasive bacterial coinfection. Approximately 50% of the decedents had developed acute respiratory distress syndrome. Among all hospitalized patients, decedents had presented for hospitalization later (median, 3 vs 2 days after illness onset; P < .05) and received oseltamivir later (median, 6.5 vs 3 days; P < .01) than surviving patients. Hospitalized patients who died were less likely to have received oseltamivir within 2 days of hospitalization than hospitalized patients who survived (61% vs 96%; P < .01). CONCLUSIONS. With community-wide transmission of 2009 H1N1 influenza A virus, timely medical care and antiviral therapy should be considered for patients with severe influenza-like illness or with underlying risk conditions for complications from influenza. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/20420514/Fatalities_associated_with_the_2009_H1N1_influenza_A_virus_in_New_York_city_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/652446 DB - PRIME DP - Unbound Medicine ER -