Tags

Type your tag names separated by a space and hit enter

Optimal micronutrients delay mitochondrial decay and age-associated diseases.
Mech Ageing Dev. 2010 Jul-Aug; 131(7-8):473-9.MA

Abstract

Three of our research efforts are reviewed, which suggest that optimizing metabolism will delay aging and the diseases of aging in humans. (1) Research on delay of the mitochondrial decay of aging by supplementing rats with lipoic acid and acetyl carnitine. (2) The triage theory, which posits that modest micronutrient deficiencies (common in much of the population) accelerate molecular aging, including mitochondrial decay, and supportive evidence, including an analysis in depth of vitamin K, that suggests the importance of achieving optimal micronutrient intake for longevity. (3) The finding that decreased enzyme binding constants (increased Km) for coenzymes (or substrates) can result from protein deformation and loss of function due to loss of membrane fluidity with age, or to polymorphisms or mutation. The loss of enzyme function can be ameliorated by high doses of a B vitamin, which raises coenzyme levels, and indicates the importance of understanding the effects of age, or polymorphisms, on micronutrient requirements.

Authors+Show Affiliations

Children's Hospital Oakland Research Institute, Nutrition and Metabolism Center, Oakland, CA 94609, USA. bames@chori.org

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20420847

Citation

Ames, Bruce N.. "Optimal Micronutrients Delay Mitochondrial Decay and Age-associated Diseases." Mechanisms of Ageing and Development, vol. 131, no. 7-8, 2010, pp. 473-9.
Ames BN. Optimal micronutrients delay mitochondrial decay and age-associated diseases. Mech Ageing Dev. 2010;131(7-8):473-9.
Ames, B. N. (2010). Optimal micronutrients delay mitochondrial decay and age-associated diseases. Mechanisms of Ageing and Development, 131(7-8), 473-9. https://doi.org/10.1016/j.mad.2010.04.005
Ames BN. Optimal Micronutrients Delay Mitochondrial Decay and Age-associated Diseases. Mech Ageing Dev. 2010 Jul-Aug;131(7-8):473-9. PubMed PMID: 20420847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimal micronutrients delay mitochondrial decay and age-associated diseases. A1 - Ames,Bruce N, Y1 - 2010/04/24/ PY - 2009/11/20/received PY - 2010/04/06/revised PY - 2010/04/16/accepted PY - 2010/4/28/entrez PY - 2010/4/28/pubmed PY - 2010/12/29/medline SP - 473 EP - 9 JF - Mechanisms of ageing and development JO - Mech Ageing Dev VL - 131 IS - 7-8 N2 - Three of our research efforts are reviewed, which suggest that optimizing metabolism will delay aging and the diseases of aging in humans. (1) Research on delay of the mitochondrial decay of aging by supplementing rats with lipoic acid and acetyl carnitine. (2) The triage theory, which posits that modest micronutrient deficiencies (common in much of the population) accelerate molecular aging, including mitochondrial decay, and supportive evidence, including an analysis in depth of vitamin K, that suggests the importance of achieving optimal micronutrient intake for longevity. (3) The finding that decreased enzyme binding constants (increased Km) for coenzymes (or substrates) can result from protein deformation and loss of function due to loss of membrane fluidity with age, or to polymorphisms or mutation. The loss of enzyme function can be ameliorated by high doses of a B vitamin, which raises coenzyme levels, and indicates the importance of understanding the effects of age, or polymorphisms, on micronutrient requirements. SN - 1872-6216 UR - https://www.unboundmedicine.com/medline/citation/20420847/Optimal_micronutrients_delay_mitochondrial_decay_and_age_associated_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0047-6374(10)00087-4 DB - PRIME DP - Unbound Medicine ER -